Cancer: looking outside the genome

The Hallmarks of Cancer

2000 • 27,569 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

The structural and mechanical complexity of cell-growth control

1999 • 769 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy.

1999 • 666 citations

Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia.

1997 • 546 citations

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

1991 • 441 citations

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

2000 • 400 citations

The onset and extent of genomic instability in sporadic colorectal tumor progression

1999 • 388 citations

Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis

1999 • 301 citations

The coming Kuhnian revolution in biology

1997 • 282 citations

Tissue structure, nuclear organization, and gene expression in normal and malignant breast.

1999 • 247 citations

Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors.

2000 • 95 citations

Accomplishments in Cancer Research

1991 • 92 citations

Accomplishments in cancer research, 1985

1987 • 79 citations

The control of growth and differentiation in normal and leukemic blood cells

1990 • 79 citations

The Bioinformatics Gold Rush

2000 • 48 citations

The ends of understanding

1997 • 41 citations

Many mutations in cancers.

1996 • 31 citations

Gene expression patterns and cancer

1998 • 23 citations

The Santayana Syndrome II: Problems in Reasoning and Learning About Error

1997 • 7 citations