Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Handbook of Proteolytic Enzymes

2004 • 2,698 citations

Baculovirus expression vectors: a laboratory manual.

1992 • 1,799 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

The Handbook of proteolytic enzymes

1998 • 1,123 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

Quantitative Zymography: Detection of Picogram Quantities of Gelatinases

1994 • 866 citations

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

1990 • 677 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 • 606 citations

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

1994 • 522 citations

Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κB

1998 • 500 citations

Molecular insights into cancer invasion: strategies for prevention and intervention.

1995 • 500 citations

Baculovirus expression vectors: A laboratory manual

1993 • 478 citations

Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat

1997 • 403 citations

Regulation of the Receptor Specificity and Function of the Chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) by Dipeptidyl Peptidase IV (CD26)-mediated Cleavage

1997 • 340 citations

CD26: a surface protease involved in T-cell activation

1994 • 330 citations

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

1995 • 324 citations

Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue.

1994 • 296 citations

Amino-terminal Truncation of Chemokines by CD26/Dipeptidyl-peptidase IV

1998 • 266 citations

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.

1993 • 261 citations

The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis.

1996 • 246 citations

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

1994 • 242 citations

Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells.

1988 • 236 citations

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

1996 • 234 citations

A factor X-activating cysteine protease from malignant tissue.

1981 • 221 citations

Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin.

1993 • 183 citations

Cloning and functional expression of the T cell activation antigen CD26.

1992 • 176 citations

MT-MMP, the cell surface activator of proMMP-2 (progelatinase A), is expressed with its substrate in mouse tissue during embryogenesis

1996 • 160 citations

Identification of the 170-kDa Melanoma Membrane-bound Gelatinase (Seprase) as a Serine Integral Membrane Protease

1997 • 155 citations

Protein and RNA Synthesis in the Skeletal Muscle of Hereditary Dystrophic Mouse

1975 • 149 citations

Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11.

1994 • 143 citations

Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease.

1982 • 132 citations

Circulating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2*

1997 • 131 citations

Distribution of the 72-kd type IV collagenase in nonneoplastic and neoplastic thyroid tissue

1992 • 119 citations

Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family.

1992 • 108 citations

Differences in regulation between nuclear and cytoplasmic Ca2+ in cultured smooth muscle cells

1992 • 108 citations

Fibroblast activation protein: Purification, epitope mapping and induction by growth factors

1994 • 107 citations

A simple method for calculating Km and V from a single enzyme reaction progress curve

1977 • 83 citations

Mouse fibroblast activation protein: Molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers

1997 • 80 citations

Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme

1993 • 79 citations

Engineering Antibodies for Therapy

1992 • 75 citations

The gene for fibroblast activation protein α (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23

1995 • 70 citations

Melanoma. An Ultrastructural Study of the Host Inflammatory and Vascular Responses

1980 • 63 citations

Expression of sucrase-isomaltase and dipeptidylpeptidase IV in human small intestine and colon

1991 • 62 citations

Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens

1998 • 61 citations

Metabolism and functions of neuropeptide Y

1996 • 57 citations

Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13

1995 • 52 citations

Up-regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-β in articular chondrocytes is mediated by serine/threonine and tyrosine kinases

1998 • 46 citations

Inflammatory Response in Cervicallntraepithelial Neoplasia and Squamous Cell Carcinoma of the Uterine Cervix

1997 • 46 citations

Post-secretory processing of regulatory peptides: The pancreatic polypeptide family as a model example

1994 • 41 citations

Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7

1993 • 36 citations

Studies on Streptomyces griseus protease

1968 • 36 citations

Flow cytometry in the clinical laboratory

1988 • 35 citations

A sensitive and specific assay for dipeptidyl-aminopeptidase II in serum and tissues by liquid chromatography-fluorometry

1985 • 32 citations

Influence on proline‐specific enzymes of a substrate containing the thioxoaminoacyl–prolyl peptide bond

1994 • 31 citations

Further Confirmation of Carboxypeptidase Y as a Metal-Free Enzyme Having a Reactive Serine Residue<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1975 • 24 citations

Biosynthesis of lysosomal enzymes in cells of the End3 complementation group conditionally defective in endosomal acidification

1991 • 20 citations

Contributions of protein structure-based drug design to cancer chemotherapy.

1997 • 19 citations

The T-cell receptor associated ξ-chain is required but not sufficient for CD26 (dipeptidylpeptidase IV) mediated signaling

1997 • 11 citations

Fluorographic detection of tritrium-labelled proteins in immunoelectropherograms with the water-soluble fluor, sodium salicylate

1983 • 5 citations