E2F and cell cycle control: a double-edged sword

Translating the Histone Code

2001 • 9,488 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

The Rb/E2F pathway: expanding roles and emerging paradigms

2000 • 1,125 citations

E2F integrates cell cycle progression with DNA repair, replication, and G₂/M checkpoints

2002 • 1,102 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

2001 • 1,046 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Requirement for a functional Rb-1 gene in murine development

1992 • 1,015 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

Rb targets histone H3 methylation and HP1 to promoters

2001 • 892 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G ₀ Cells

2002 • 748 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

Distinct roles for E2F proteins in cell growth control and apoptosis

1997 • 694 citations

Regulation of E2F1 activity by acetylation

2000 • 654 citations

Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

2000 • 650 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

2000 • 619 citations

The E2F1–3 transcription factors are essential for cellular proliferation

2001 • 595 citations

Apaf-1 is a transcriptional target for E2F and p53

2001 • 590 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

2002 • 475 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.

2001 • 436 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Control of pRB phosphorylation

1998 • 389 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Chk2 activates E2F-1 in response to DNA damage

2003 • 377 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

Active Transcriptional Repression by the Rb–E2F Complex Mediates G1 Arrest Triggered by p16INK4a, TGFβ, and Contact Inhibition

1999 • 355 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

The retinoblastoma gene family: cousins with overlapping interests

1998 • 337 citations

Targeted disruption of p107: functional overlap between p107 and Rb.

1996 • 333 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

2000 • 326 citations

E2f3 is critical for normal cellular proliferation

2000 • 323 citations

E2F Repression by C/EBPα Is Required for Adipogenesis and Granulopoiesis In Vivo

2001 • 321 citations

Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1999 • 317 citations

E2Fs Regulate Adipocyte Differentiation

2002 • 310 citations

Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16^INK4A-Mediated Growth Suppression

1996 • 297 citations

E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control

2000 • 292 citations

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

1997 • 284 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

Acetylation control of the retinoblastoma tumour-suppressor protein

2001 • 280 citations

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

1999 • 279 citations

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice

1998 • 278 citations

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1997 • 266 citations

c-Myc Is a Critical Target for C/EBPα in Granulopoiesis

2001 • 260 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter

1996 • 248 citations

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

2001 • 248 citations

E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways

1999 • 244 citations

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.

1994 • 242 citations

General transcription factors bind promoters repressed by Polycomb group proteins

2001 • 240 citations

DNA replication control through interaction of E2F–RB and the origin recognition complex

2001 • 234 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1997 • 228 citations

Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis

2001 • 214 citations

Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53

1999 • 213 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

1996 • 207 citations

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization

1997 • 195 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability

2000 • 189 citations

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting

1998 • 177 citations

p19ARF targets certain E2F species for degradation

2001 • 177 citations

Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages

2000 • 173 citations

C/EBPα Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated Transcription

2000 • 172 citations

In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression

1995 • 165 citations

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

1995 • 164 citations

Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.

1996 • 154 citations

E2F1 Has Both Oncogenic and Tumor-Suppressive Properties in a Transgenic Model

1999 • 152 citations

Cell Cycle Regulation of E2F Site Occupation in Vivo

1996 • 152 citations

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

1996 • 151 citations

An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells

1987 • 149 citations

Regulation of E2F transcription by cyclin E–Cdk2 kinase mediated through p300/CBP co-activators

2000 • 144 citations

Complex Transcriptional Regulatory Mechanisms Control Expression of the E2F3 Locus

2000 • 139 citations

Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

Subunit Composition Determines E2F DNA-Binding Site Specificity

1997 • 132 citations

Requirements for Cell Cycle Arrest by p16INK4a

2000 • 131 citations

Mechanism of Transcriptional Repression of E2F by the Retinoblastoma Tumor Suppressor Protein

1999 • 128 citations

The CBP co-activator stimulates E2F1/DP1 activity

1996 • 117 citations

E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner

2001 • 108 citations

Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle

1996 • 107 citations

Retinoblastoma protein in growth suppression and death protection

1997 • 91 citations

Apoptotic and Growth-Promoting Activity of E2F Modulated by MDM2

2000 • 88 citations

The role of protein stability in the cell cycle and cancer

1998 • 87 citations

p19^ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

2002 • 86 citations

Cloning and characterization of human DP2, a novel dimerization partner of E2F.

1995 • 81 citations

E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest

1996 • 76 citations

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

1996 • 73 citations

A rough guide to a smooth brain

2000 • 64 citations

Inhibition of in vitro myogenic differentiation by cellular transcription factor E2F1.

1995 • 61 citations

p14ARF regulates E2F activity

2002 • 59 citations

Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors

1997 • 48 citations

Enhanced protein stability: a novel mechanism of D-type cyclin over-abundance identified in human sarcoma cells.

1996 • 47 citations

Molecular and functional characterisation of E2F-5, a new member of the E2F family.

1995 • 43 citations

Balancing proliferation and apoptosis in vivo: the Goldilocks theory of E2F/DP action

1999 • 42 citations

Active repression and E2F inhibition by pRB are biochemically distinguishable

2001 • 38 citations

E2F-1 induces proliferation-specific genes and suppresses squamous differentiation-specific genes in human epidermal keratinocytes

2000 • 37 citations

Involvement of the Retinoblastoma Protein in Monocytic and Neutrophilic Lineage Commitment of Human Bone Marrow Progenitor Cells

1999 • 35 citations

Endogenous E2F-1 promotes timely G ₀ exit of resting mouse embryo fibroblasts

1998 • 33 citations

Granulocytic differentiation of myeloid progenitor cells by p130, the retinoblastoma tumor suppressor homologue

1999 • 16 citations