E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

2000 • 619 citations

Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

1998 • 524 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1997 • 435 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

Control of pRB phosphorylation

1998 • 389 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

Active Transcriptional Repression by the Rb–E2F Complex Mediates G1 Arrest Triggered by p16INK4a, TGFβ, and Contact Inhibition

1999 • 355 citations

The retinoblastoma gene family: cousins with overlapping interests

1998 • 337 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

E2f3 is critical for normal cellular proliferation

2000 • 323 citations

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

2000 • 281 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Induced Expression of p16^INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes

1999 • 226 citations

Functions of the retinoblastoma protein

1999 • 204 citations

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting

1998 • 177 citations

Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages

2000 • 173 citations

Requirements for Cell Cycle Arrest by p16INK4a

2000 • 131 citations

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

1997 • 131 citations

Induction of p21^WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16^INK4a

1999 • 126 citations

Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

1996 • 115 citations

Requirement of Cyclin E-Cdk2 Inhibition in p16^INK4a-Mediated Growth Suppression

1998 • 114 citations

Expression patterns of the E2F family of transcription factors during mouse nervous system development

1997 • 78 citations

E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor β through E2F binding sites

1997 • 58 citations

Expression patterns of the E2F family of transcription factors during murine epithelial development.

1997 • 56 citations

Endogenous E2F-1 promotes timely G ₀ exit of resting mouse embryo fibroblasts

1998 • 33 citations