Transcriptional and Transforming Activities of the Adenovirus E1A Proteins

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region

1985 • 1,244 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

An adenovirus type 5 early gene function regulates expression of other early viral genes.

1979 • 791 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter

1985 • 763 citations

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

1979 • 756 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Transformation of rat cells by DNA of human adenovirus 5

1973 • 664 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Identification of a cellular transcription factor involved in E1A trans-activation

1986 • 551 citations

Heat shock factor is regulated differently in yeast and HeLa cells

1987 • 489 citations

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex

1988 • 488 citations

Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA box-promoter interactions of TFIID.

1988 • 477 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

1986 • 460 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

Viral DNA in transformed cells

1974 • 429 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

1990 • 391 citations

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1985 • 383 citations

Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

1983 • 373 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Multiple functional domains in the adenovirus E1A gene

1987 • 361 citations

Analysis of adenovirus transforming proteins from early regions 1A and 1B with antisera to inducible fusion antigens produced in Escherichia coli

1984 • 349 citations

Studies on In Vitro Transformation by DNA and DNA Fragments of Human Adenoviruses and Simian Virus 40

1974 • 334 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

1990 • 327 citations

Generation of cDNA Probes Directed by Amino Acid Sequence: Cloning of Urate Oxidase

1988 • 325 citations

The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

1989 • 307 citations

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein

1990 • 295 citations

Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection.

1983 • 295 citations

Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation

1988 • 292 citations

Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

1988 • 290 citations

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

1987 • 290 citations

Mechanism of action of a yeast activator: Direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions

1988 • 286 citations

A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.

1987 • 284 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T Cells

1988 • 265 citations

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

1989 • 262 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

1981 • 237 citations

Two regions of the adenovirus early region 1A proteins are required for transformation

1988 • 232 citations

A TATA box implicated in E1A transcriptional activation of a simple adenovirus 2 promoter

1987 • 227 citations

Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products

1985 • 223 citations

Promoter specificity and modulation of RNA polymerase II transcription

1989 • 221 citations

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

1990 • 221 citations

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

1985 • 213 citations

Defective transforming capacity of adenovirus type 5 host-range mutants

1978 • 211 citations

A cellular transcription factor E4F1 interacts with an E1a-inducible enhancer and mediates constitutive enhancer function in vitro.

1987 • 208 citations

Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation.

1987 • 201 citations

Activation of transcription factor IIIC by the adenovirus E1A protein

1988 • 197 citations

E1A 13S and 12S mRNA Products Made in Escherichia coli Both Function as Nucleus-Localized Transcription Activators but Do Not Directly Bind DNA

1985 • 190 citations

Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.

1987 • 189 citations

Enhancement of RNA polymerase III transcription by the E1A gene product of adenovirus

1985 • 188 citations

Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly

1988 • 186 citations

A human parvovirus, adeno-associated virus, as a eucaryotic vector: transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase.

1984 • 185 citations

ADENOVIRUS E1A PROTEIN PARADIGM VIRAL TRANSACTIVATOR

1989 • 184 citations

Control of adenovirus early gene expression: A class of immediate early products

1980 • 182 citations

Transcription Control by Oncogenes

1985 • 176 citations

The pseudorabies immediate early protein stimulates in vitro transcription by facilitating TFIID: promoter interactions.

1988 • 176 citations

Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.

1987 • 171 citations

Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the major late transcription factor

1989 • 167 citations

Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection.

1984 • 167 citations

Adenovirus E1A coding sequences that enable ras and pmt oncogenes to transform cultured primary cells.

1986 • 161 citations

Adenovirus stimulation of transcription by RNA polymerase III: evidence for an E1A-dependent increase in transcription factor IIIC concentration.

1986 • 156 citations

The release of growth arrest by microinjection of adenovirus E1A DNA.

1985 • 154 citations

Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.

1984 • 153 citations

Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes.

1984 • 150 citations

The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex.

1989 • 148 citations

E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.

1989 • 147 citations

Adenovirus type 2 early proteins synthesized in vitro and in vivo: identification in infected cells of the 38,000- to 50,000- molecular-weight protein encoded by the left end of the adenovirus type 2 genome

1978 • 146 citations

Dissection of overlapping functions within the adenovirus type 5 E1A gene.

1984 • 146 citations

The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA

1990 • 145 citations

Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.

1987 • 142 citations

Adenovirus EIIA early promoter: transcriptional control elements and induction by the viral pre-early EIA gene, which appears to be sequence independent.

1985 • 140 citations

Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex.

1987 • 140 citations

Recombinant Fragment of Protein Kinase Inhibitor Blocks Cyclic AMP-Dependent Gene Transcription

1987 • 139 citations

Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.

1984 • 138 citations

The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding.

1989 • 137 citations

Lytic and transforming functions of individual products of the adenovirus E1A gene

1986 • 136 citations

Protein Kinases in the Brain

1985 • 134 citations

Identification of an E1A-inducible cellular factor that interacts with regulatory sequences within the adenovirus E4 promoter.

1987 • 133 citations

Transcription of Class III Genes Activated by Viral Immediate Early Proteins

1985 • 132 citations

An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription.

1985 • 131 citations

Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.

1988 • 128 citations

Transcriptional Control Regions: Nucleotide Sequence Requirements for Initiation by RNA Polymerase II and III

1981 • 125 citations

Purification of a factor specific for the upstream element of the adenovirus-2 major late promoter.

1986 • 123 citations

Selective Induction of Human Heat Shock Gene Transcription by the Adenovirus E1A Gene Products, Including the 12S E1A Product

1987 • 123 citations

The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteins

1989 • 122 citations

The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene.

1986 • 122 citations

Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells

1987 • 120 citations

Developmental control of a promoter-specific factor that is also regulated by the E1A gene product

1987 • 120 citations

Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B

1983 • 120 citations

Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor.

1988 • 120 citations

The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for trans-activation.

1988 • 119 citations

Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini

1983 • 118 citations

E1A Transcription Induction: Enhanced Binding of a Factor to Upstream Promoter Sequences

1986 • 116 citations

Viral nucleic acid sequences in transformed cells

1976 • 112 citations

The adenovirus-2 early EIIa transcription unit possesses two overlapping promoters with different sequence requirements for EIa-dependent stimulation.

1985 • 111 citations

Identification of a factor in HeLa cells specific for an upstream transcriptional control sequence of an EIA-inducible adenovirus promoter and its relative abundance in infected and uninfected cells.

1986 • 109 citations

An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.

1990 • 108 citations

Comparison of nucleotide sequences of the early E1a regions for subgroups A, B and C of human adenoviruses

1980 • 107 citations

Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.

1989 • 107 citations

An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity.

1989 • 105 citations

DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation.

1989 • 104 citations

The adenovirus DNA-binding protein stimulates the rate of transcription directed by adenovirus and adeno-associated virus promoters

1990 • 104 citations

The TATA homology and the mRNA 5′ untranslated sequence are not required for expression of essential adenovirus E1A functions

1982 • 103 citations

Binding of the Rb1 protein to E1A products is required for adenovirus transformation.

1989 • 101 citations

The Adenovirus EIIA Enhancer

1989 • 100 citations

Downstream sequences affect transcription initiation from the adenovirus major late promoter.

1986 • 97 citations

A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties.

1987 • 95 citations

Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity.

1984 • 94 citations

Repression of insulin gene expression by adenovirus type 5 E1a proteins.

1987 • 90 citations

Activation of the E2F transcription factor in adenovirus-infected cells involves E1A-dependent stimulation of DNA-binding activity and induction of cooperative binding mediated by an E4 gene product

1990 • 90 citations

Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene.

1988 • 88 citations

Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation.

1984 • 86 citations

General repression of enhanson activity by the adenovirus-2 E1A proteins.

1990 • 83 citations

Splicing of adenovirus 2 early region 1A mRNAs is non-sequential

1983 • 83 citations

The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation

1989 • 83 citations

Differential activation of RNA polymerase III-transcribed genes by the polyomavirus enhancer and the adenovirus E1A gene products

1985 • 81 citations

Transactivation of plasmid-borne promoters by adenovirus and several herpes group viruses

1984 • 81 citations

DNA-binding properties of an adenovirus 289R E1A protein.

1988 • 77 citations

Induction of cellular DNA synthesis by purified adenovirus E1A proteins

1986 • 75 citations

Functional Relation Between HTLV-II x and Adenovirus E1A Proteins in Transcriptional Activation

1985 • 75 citations

Two promoter-specific host factors interact with adjacent sequences in an EIA-inducible adenovirus promoter.

1987 • 74 citations

Activation of a preexisting cellular factor as a basis for adenovirus E1A-mediated transcription control.

1988 • 74 citations

Control of adenovirus late promoter expression in two human cell lines.

1985 • 69 citations

An adenovirus E1A protein domain activates transcription in vivo and in vitro in the absence of protein synthesis

1988 • 69 citations

Induction of transcription factor AP-1 by adenovirus E1A protein and cAMP.

1989 • 69 citations

Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression

1985 • 69 citations

The adenovirus-2 EIIa eariy gene promoter: sequences required for efficientin vitroandin vivotranscription

1983 • 68 citations

EivF, a factor required for transcription of the adenovirus EIV promoter, binds to an element involved in EIa-dependent activation and cAMP induction.

1988 • 67 citations

cAMP acts in synergy with E1A protein to activate transcription of the adenovirus early genes E4 and E1A.

1988 • 66 citations

Phosphorylation of cellular proteins regulates their binding to the cAMP response element

1989 • 66 citations

Selective induction of human heat shock gene transcription by the adenovirus E1A gene products, including the 12S E1A product.

1987 • 65 citations

Cellular transcription factor binds to adenovirus early region promoters and to a cyclic AMP response element

1988 • 63 citations

E1A 13S and 12S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNA.

1985 • 62 citations

E2F from adenovirus-infected cells binds cooperatively to DNA containing two properly oriented and spaced recognition sites.

1989 • 61 citations

The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.

1988 • 61 citations

Mechanisms of Viral-Mediated Trans-Activation of Transcription

1989 • 60 citations

Factors responsible for the higher transcriptional activity of extracts of adenovirus-infected cells fractionate with the TATA box transcription factor.

1988 • 60 citations

Regulation of Adenovirus Mrna Formation

1986 • 59 citations

Trans-activation of the human immunodeficiency virus long terminal repeat sequences, expressed in an adenovirus vector, by the adenovirus E1A 13S protein.

1988 • 57 citations

Increased MHC H–2K gene transcription in cultured mouse embryo cells after adenovirus infection

1985 • 56 citations

Two functions encoded by adenovirus early region 1A are responsible for the activation and repression of the DNA-binding protein gene.

1985 • 56 citations

E1A-dependent trans-activation of the c-fos promoter requires the TATAA sequence.

1990 • 55 citations

Adenovirus E1a Proteins Repress Expression from Polyomavirus Early and Late Promoters

1986 • 54 citations

Adenovirus E1a ras cooperation activity is separate from its positive and negative transcription regulatory functions.

1988 • 53 citations

The molecular structure of the 9 S mRNA from early region 1A of adenovirus serotype 2

1983 • 52 citations

Identification of sequences responsible for positive and negative regulation by E1A in the promoter of H-2Kbm1 class I MHC gene.

1990 • 52 citations

Promoter trans-activation of protooncogenes c-fos and c-myc, but not c-Ha-ras, by products of adenovirus early region 1A.

1987 • 52 citations

Adenovirus E3-early promoter: sequences required for activation by E1A

1985 • 51 citations

Regulation of adenovirus gene expression in human WI38 cells by an E1B-encoded tumor antigen.

1986 • 50 citations

Organization of the transcriptional control region of the E1b gene of adenovirus type 5

1988 • 49 citations

Adenovirus transforming 19-kD T antigen has an enhancer-dependent trans-activation function and relieves enhancer repression mediated by viral and cellular genes.

1987 • 48 citations

The immunoglobulin heavy chain enhancer is stimulated by the adenovirus type 2 E1A products in mouse fibroblasts.

1986 • 47 citations

Differential response of multiple ϵ-globin cap sites to cis- and trans-acting controls

1984 • 45 citations

Negative regulatory sequences in the Ela-inducible enhancer of the adenovirus-2 eariy EIIa promoter

1986 • 45 citations

Transactivation of host and viral genes by the adenovirus E1B 19K tumor antigen.

1987 • 45 citations

Relationship between the transforming and transcriptional regulatory functions of adenovirus 2 E1a oncogene

1987 • 44 citations

Response of individual adenovirus promoters to the products of the E1A gene.

1987 • 44 citations

Sarkosyl defines three intermediate steps in transcription initiation by RNA polymerase III: application to stimulation of transcription by E1A.

1990 • 44 citations

NF-kappa B-mediated activation of the human immunodeficiency virus enhancer: site of transcriptional initiation is independent of the TATA box

1989 • 43 citations

Replication-induced stimulation of the major late promoter of adenovirus is correlated to the binding of a factor to sequences in the first intron

1988 • 43 citations

Distinguishable promoter elements are involved in transcriptional activation by E1a and cyclic AMP.

1989 • 42 citations

Sequence-specific trans-activation of the adenovirus EIIa early promoter by the viral EIV transcription unit.

1985 • 42 citations

Specific cellular proteins bind to critical promoter sequences of the adenovirus early EIIa promoter

1987 • 41 citations

Adenovirus early region 1A protein increases the number of template molecules transcribed in cell-free extracts.

1986 • 41 citations

The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expression

1989 • 40 citations

Activation of Adenovirus Promoters by the Adenovirus E1A Protein in Cell-Free Extracts

1987 • 40 citations

Genetic mapping of a major site of phosphorylation in adenovirus type 2 E1A proteins

1986 • 40 citations

The role of adenovirus early region 1A in the regulation of early regions 2A and 1B expression

1983 • 39 citations

Multiple transcription factor binding sites mediate adenovirus E1A transactivation

1989 • 37 citations

Concentration Dependence of Transcriptional Transactivation in Inducible E1A-Containing Human Cells

1988 • 31 citations

Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene.

1986 • 31 citations

Gene organization of the transforming region of weakly oncogenic adenovirus type 7: The E1a region

1980 • 29 citations

Growth factor(s) produced during infection with an adenovirus variant stimulates proliferation of nonestablished epithelial cells.

1987 • 28 citations

E1a inducibility of the adenoviral early E2a promoter is determined by specific combinations of sequence elements

1987 • 26 citations

E1a transactivation of human HSP70 gene promoter substitution mutants is independent of the composition of upstream and TATA elements.

1990 • 25 citations

Adenovirus E1A protein activation of an integrated viral gene.

1984 • 25 citations

Adenovirus 2 peptide IX gene is expressed only on replicated DNA molecules.

1986 • 25 citations

The adenovirus EII early promoter has multiple EIA-sensitive elements, two of which function cooperatively in basal and virus-induced transcription

1990 • 23 citations

TPA can overcome the requirement for EIa and together act synergistically in stimulating expression of the adenovirus EIII promoter.

1989 • 23 citations

Phosphorylation at serine 89 induces a shift in gel mobility but has little effect on the function of adenovirus type 5 E1A proteins

1989 • 22 citations

Repression of cytochrome P‐450c gene expression by cotransfection with adenovirus E1a DNA

1989 • 22 citations

Analysis of multiple forms of human adenovirus type 5 E1A polypeptides using an anti-peptide antiserum specific for the amino terminus

1985 • 22 citations

Analysis of phosphorylation sites in the exon 1 region of E1A proteins of human adenovirus type 5

1989 • 21 citations

Activation of the adenovirus 2 protein IX promoter by DNA replication in a transient expression assay

1987 • 21 citations

Sequence-Specific Activation of Transcription by Adenovirus EIa Products Is Observed in HeLa Cells but Not in 293 Cells

1986 • 20 citations

Cis and trans activation of adenovirus IVa₂gene transcription

1985 • 19 citations

Mutations that affect phosphorylation of the adenovirus DNA-binding protein alter its ability to enhance its own synthesis

1989 • 18 citations

Adenovirus E1A products activate the Ig k-chain enhancer in fibroblasts. A possible involvement of the NF-kB binding site.

1989 • 17 citations

Adenovirus E1a proteins repress expression from polyomavirus early and late promoters.

1986 • 16 citations

Analysis of transformed cell variants of BHK21 C13 isolated as survivors of adenovirus type 5 infections

1975 • 11 citations

Concentration dependence of transcriptional transactivation in inducible E1A-containing human cells.

1988 • 11 citations

Modulation of HPV18 and BPV1 transcription in human keratinocytes by simian virus 40 large T antigen and adenovirus type 5 E1A antigen

1990 • 8 citations

In vitro trans-activation by chemically synthesized adenovirus region 3 peptides

1989 • 8 citations

Mutational analysis of autonomously functioning trans-activating peptides encoded by adenovirus E1A: evidence for two subdomains

1989 • 6 citations

Sequence-specific activation of transcription by adenovirus EIa products is observed in HeLa cells but not in 293 cells.

1986 • 5 citations