Analysis of phosphorylation sites in the exon 1 region of E1A proteins of human adenovirus type 5

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

An adenovirus type 5 early gene function regulates expression of other early viral genes.

1979 • 791 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

1979 • 756 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product

1982 • 454 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Multiple functional domains in the adenovirus E1A gene

1987 • 361 citations

Host-range mutants of adenovirus type 5 defective for growth in HeLa cells

1977 • 330 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

Transcriptional activation and subsequent control of the human heat shock gene during adenovirus infection.

1983 • 295 citations

Functional domains of adenovirus type 5 E1a proteins

1987 • 283 citations

RNA polymerase and the regulation of transcription

1987 • 256 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Two regions of the adenovirus early region 1A proteins are required for transformation

1988 • 232 citations

Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes.

1986 • 231 citations

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides

1985 • 227 citations

Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products

1985 • 223 citations

Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

1988 • 218 citations

Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation.

1987 • 201 citations

A Rapid, Sensitive, and Inexpensive Assay for Chloramphenicol Acetyltransferase

1987 • 196 citations

HeLa Cell β-Tubulin Gene Transcription Is Stimulated by Adenovirus 5 in Parallel with Viral Early Genes by an E1a-Dependent Mechanism

1984 • 187 citations

The structure of adenovirus 2 early nuclear and cytoplasmic RNAs

1980 • 177 citations

E1A Control of Gene Expression Is Mediated by Sequences 5′ to the Transcriptional Starts of the Early Viral Genes

1983 • 169 citations

A method for increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells

1987 • 161 citations

Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.

1984 • 153 citations

Adenovirus type 2 early proteins synthesized in vitro and in vivo: identification in infected cells of the 38,000- to 50,000- molecular-weight protein encoded by the left end of the adenovirus type 2 genome

1978 • 146 citations

Dissection of overlapping functions within the adenovirus type 5 E1A gene.

1984 • 146 citations

Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.

1987 • 142 citations

Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini

1983 • 118 citations

A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties.

1987 • 95 citations

Repression of insulin gene expression by adenovirus type 5 E1a proteins.

1987 • 90 citations

Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activation

1988 • 88 citations

Adenovirus type 2 early proteins: Assignment of the early region 1A proteins synthesized in vivo and in vitro to specific mRNAs

1981 • 81 citations

HeLa cell beta-tubulin gene transcription is stimulated by adenovirus 5 in parallel with viral early genes by an E1a-dependent mechanism.

1984 • 73 citations

Tn5 mutagenesis of the transforming genes of human adenovirus type 5

1982 • 68 citations

Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation.

1985 • 57 citations

Mapping of functional domains in adenovirus E1A proteins.

1985 • 56 citations

Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus

1983 • 54 citations

Adenovirus E1a Proteins Repress Expression from Polyomavirus Early and Late Promoters

1986 • 54 citations

The molecular structure of the 9 S mRNA from early region 1A of adenovirus serotype 2

1983 • 52 citations

A first exon-encoded domain of E1A sufficient for posttranslational modification, nuclear-localization, and induction of adenovirus E3 promoter expression in Xenopus oocytes.

1985 • 49 citations

E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes.

1983 • 46 citations

Heterogeneity of adenovirus type 5 E1A proteins: multiple serine phosphorylations induce slow-migrating electrophoretic variants but do not affect E1A-induced transcriptional activation or transformation

1988 • 40 citations

Genetic mapping of a major site of phosphorylation in adenovirus type 2 E1A proteins

1986 • 40 citations

Identification of the phosphorylation sites in early region 1A proteins of adenovirus type 5 by amino acid sequencing of peptide fragments.

1988 • 31 citations

Phosphorylation at serine 89 induces a shift in gel mobility but has little effect on the function of adenovirus type 5 E1A proteins

1989 • 22 citations

Analysis of multiple forms of human adenovirus type 5 E1A polypeptides using an anti-peptide antiserum specific for the amino terminus

1985 • 22 citations

Stabilities and interrelations of multiple species of human adenovirus type 5 early region 1 proteins in infected and transformed cells

1985 • 20 citations

Phosphorylation in vitro of Escherichia coli-produced 235R and 266R tumor antigens encoded by human adenovirus type 12 early transformation region 1A

1985 • 19 citations

Adenovirus E1a proteins repress expression from polyomavirus early and late promoters.

1986 • 16 citations

Structure and metabolism of adenovirus RNAs containing sequences from the fiber gene

1980 • 15 citations

An immunodominant domain in adenovirus type 2 early region 1A proteins

1986 • 9 citations

Transfer of functional adenovirus E1A transcription activator proteins into mammalian cells by protoplast fusion.

1986 • 8 citations