The adenovirus-2 early EIIa transcription unit possesses two overlapping promoters with different sequence requirements for EIa-dependent stimulation.

A new method for sequencing DNA.

1977 • 7,941 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Promoter Sequences of Eukaryotic Protein-Coding Genes

1980 • 971 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II

1983 • 779 citations

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells

1983 • 596 citations

Enhancer elements

1983 • 576 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions

1984 • 523 citations

Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.

1980 • 471 citations

Induction of the synthesis of a 70,000 dalton mammalian heat shock protein by the adenovirus E1A gene product

1982 • 454 citations

Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

1984 • 435 citations

Specific interaction between enhancer-containing molecules and cellular components

1984 • 374 citations

Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

1983 • 373 citations

A small segment of polyoma virus DNA enhances the expression of a cloned β-globin gene over a distance of 1400 base pairs

1981 • 339 citations

Promoters and heterogeneous 5′ termini of the messenger RNAs of adenovirus serotype 2

1981 • 289 citations

Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element

1983 • 250 citations

Signals regulating hepatitis B surface antigen transcription

1983 • 246 citations

Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene

1983 • 235 citations

Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor.

1984 • 199 citations

A trans-acting factor is responsible for the simian virus 40 enhancer activity in vitro

1985 • 196 citations

HeLa Cell β-Tubulin Gene Transcription Is Stimulated by Adenovirus 5 in Parallel with Viral Early Genes by an E1a-Dependent Mechanism

1984 • 187 citations

Regulation of the Primary Expression of the Early Adenovirus Transcription Units

1979 • 184 citations

Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter.

1982 • 178 citations

Regulation of heat-shock genes: a DNA sequence upstream of Drosophila hsp70 genes is essential for their induction in monkey cells.

1982 • 171 citations

E1A Control of Gene Expression Is Mediated by Sequences 5′ to the Transcriptional Starts of the Early Viral Genes

1983 • 169 citations

Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection.

1984 • 167 citations

Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes.

1984 • 150 citations

Purification of an adenovirus-coded DNA polymerase that is required for initiation of DNA replication

1982 • 141 citations

Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.

1984 • 138 citations

The stability of early adenovirus mRNA is controlled by the viral 72 kd DNA-binding protein

1981 • 134 citations

Possible role of the 72,000 dalton DNA-binding protein in regulation of adenovirus type 5 early gene expression

1978 • 124 citations

Stimulation ofin vitrotranscription by the upstream element of the adenovirus-2 major late promoter involves a specific factor

1984 • 113 citations

Sequence requirements for the transcription of the rabbit β-globin genein vivo: -80 region

1982 • 110 citations

Site-specific base substitution and deletion mutations that enhance or suppress transcription of the SV40 major late RNA

1982 • 107 citations

Localization of the adenovirus E1Aa protein, a positive-acting transcriptional factor, in infected cells infected cells.

1983 • 98 citations

Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity.

1984 • 94 citations

Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters

1984 • 88 citations

The E4 transcilpilonal unit of Ad2: far upstream sequences are required for its transactivation by E1A

1984 • 86 citations

Adenovirus 5 E2 transcription unit: an E1A-inducible promoter with an essential element that functions independently of position or orientation.

1984 • 86 citations

Transcriptional analysis of the adenovirus-5 EIII promoter: absence of sequence specificity for stimulation by EIa gene products

1985 • 70 citations

The adenovirus-2 EIIa eariy gene promoter: sequences required for efficientin vitroandin vivotranscription

1983 • 68 citations

The E1b promoter of Ad12 in mouse L tk- cells is activated by adenovirus region E1a.

1983 • 60 citations

Enhancing elements for activation of eukaryotic promoters

1982 • 59 citations

Specific in vitro initiation of transcription on the adenovirus type 2 early and late EII transcription units.

1981 • 52 citations

Regulation of Transcription of the Adenovirus EII Promoter by EIa Gene Products: Absence of Sequence Specificity

1984 • 50 citations

Differential response of multiple ϵ-globin cap sites to cis- and trans-acting controls

1984 • 45 citations

Adenovirus 5 E2 Transcription Unit: an E1A-Inducible Promoter with an Essential Element That Functions Independently of Position or Orientation

1984 • 40 citations

The role of adenovirus early region 1A in the regulation of early regions 2A and 1B expression

1983 • 39 citations

Localization of the Adenovirus E1A_a Protein, a Positive-Acting Transcriptional Factor, in Infected Cells Infected Cells

1983 • 37 citations

Expression of adenoviral genetic information in productively infected cells

1982 • 36 citations

Sequences locating the 5' ends of the major simian virus 40 late mRNA forms

1983 • 35 citations

DNA sequences involved in the regulation of gene expression by glucocorticoid hormones

1984 • 33 citations

Unusual heterogeneity of the 5′-termini of human adenovirus type 2 early region E2 mRNA

1984 • 4 citations