An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

Identification of a cellular transcription factor involved in E1A trans-activation

1986 • 551 citations

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1985 • 383 citations

Role of an adenovirus E2 promoter binding factor in E1A-mediated coordinate gene control.

1987 • 290 citations

The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex.

1989 • 148 citations

A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2.

1983 • 141 citations

Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex.

1987 • 140 citations

Adenovirus EIIA early promoter: transcriptional control elements and induction by the viral pre-early EIA gene, which appears to be sequence independent.

1985 • 140 citations

The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding.

1989 • 137 citations

[70] Definition and mapping of adenovirus 2 nuclear transcription

1980 • 136 citations

An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription.

1985 • 131 citations

Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells

1987 • 120 citations

The adenovirus-2 early EIIa transcription unit possesses two overlapping promoters with different sequence requirements for EIa-dependent stimulation.

1985 • 111 citations

Identification of a factor in HeLa cells specific for an upstream transcriptional control sequence of an EIA-inducible adenovirus promoter and its relative abundance in infected and uninfected cells.

1986 • 109 citations

Multiple factors are required for specific RNA cleavage at a poly(A) addition site.

1988 • 106 citations

An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity.

1989 • 105 citations

Identification and characterization of an immunologically conserved adenovirus early region 11,000 Mr protein and its association with the nuclear matrix

1982 • 102 citations

The Adenovirus EIIA Enhancer

1989 • 100 citations

mRNAs from human adenovirus 2 early region 4

1984 • 95 citations

The adenovirus E4 gene, in addition to the E1A gene, is important for trans-activation of E2 transcription and for E2F activation

1989 • 83 citations

Regulation of early adenovirus gene expression

1987 • 80 citations

Activation of a preexisting cellular factor as a basis for adenovirus E1A-mediated transcription control.

1988 • 74 citations

The Adenovirus-Inducible Factor E2F Stimulates Transcription after Specific DNA Binding

1989 • 52 citations

Sequence-specific trans-activation of the adenovirus EIIa early promoter by the viral EIV transcription unit.

1985 • 42 citations

Specific cellular proteins bind to critical promoter sequences of the adenovirus early EIIa promoter

1987 • 41 citations

The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expression

1989 • 40 citations

Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids

1989 • 36 citations