Promoter-Region Hypermethylation and Gene Silencing in Human Cancer

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

1998 • 1,472 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins

1998 • 1,317 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1992 • 1,027 citations

The essentials of DNA methylation

1992 • 960 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 • 920 citations

DNA methylation and gene activity

1988 • 904 citations

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 ^WAF1

1997 • 895 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 • 803 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Spl elements protect a CpG island from de novo methylation

1994 • 713 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

Diversity and specialization of mammalian SWI/SNF complexes.

1996 • 703 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

Maintenance of genomic methylation requires a SWI2/SNF2-like protein

1999 • 689 citations

CpG islands as gene markers in the vertebrate nucleus

1987 • 687 citations

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.

1994 • 667 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

A mammalian protein with specific demethylase activity for mCpG DNA

1999 • 624 citations

Aging and DNA methylation in colorectal mucosa and cancer.

1998 • 620 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

The Enhanceosome and Transcriptional Synergy

1998 • 545 citations

Transcription Factor Sp1 Is Essential for Early Embryonic Development but Dispensable for Cell Growth and Differentiation

1997 • 524 citations

Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients.

1999 • 507 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

The Sins of the Fathers and Mothers

1999 • 489 citations

Alternative chromatin structure at CpG islands

1990 • 480 citations

Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia–lymphoma cells

1998 • 436 citations

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.

1997 • 420 citations

DNA methylation errors and cancer.

1996 • 405 citations

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.

1999 • 374 citations

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

1999 • 369 citations

Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.

1999 • 366 citations

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

1998 • 366 citations

Methylation of the p15INK4b Gene in Myelodysplastic Syndromes Is Frequent and Acquired During Disease Progression

1998 • 352 citations

Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation

1997 • 323 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 319 citations

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial Cancers

1999 • 316 citations

Increased Cytosine DNA-Methyltransferase Activity During Colon Cancer Progression

1993 • 315 citations

High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.

1991 • 311 citations

Loss of methylation activates Xist in somatic but not in embryonic cells.

1995 • 300 citations

Association between CpG island methylation and microsatellite instability in colorectal cancer.

1997 • 295 citations

Dependence of transcriptional repression on CpG methylation density.

1994 • 294 citations

De Novo Methylation of CpG Island Sequences in Human Fibroblasts Overexpressing DNA (Cytosine-5-)-Methyltransferase

1996 • 290 citations

Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

1998 • 260 citations

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1993 • 255 citations

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

1996 • 254 citations

Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter

1999 • 251 citations

Isolation and characterization of the cDNA encoding human DNA methyltransferase

1992 • 250 citations

Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos

1999 • 237 citations

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1998 • 231 citations

Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes.

1993 • 222 citations

Methylation of Discrete Regions of the O⁶-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1997 • 214 citations

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

1997 • 214 citations

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.

1994 • 200 citations

p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas.

1997 • 197 citations

DNA methylation: Molecular biology and biological significance

1993 • 193 citations

Regulation of DNA Methylation by the Ras Signaling Pathway

1995 • 190 citations

DNA methylation and chromatin structure

1991 • 182 citations

Unrestricted cell cycling and cancer

1995 • 164 citations

Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

1998 • 158 citations

Role of the Xist Gene in X Chromosome Choosing

1998 • 157 citations

Expression of Antisense to DNA Methyltransferase mRNA Induces DNA Demethylation and Inhibits Tumorigenesis

1995 • 155 citations

Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma.

1998 • 150 citations

Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells

1997 • 146 citations

Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo.

1993 • 138 citations

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1996 • 138 citations

Multiple SWItches to turn on chromatin?

1996 • 131 citations

ADVANCES IN CANCER RESEARCH

1936 • 113 citations

Chromatin remodeling: a marriage between two families?

1998 • 108 citations

Mechanisms for the involvement of DNA methylation in colon carcinogenesis.

1996 • 106 citations

Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase

1997 • 99 citations

New 5′ Regions of the Murine and Human Genes for DNA (Cytosine-5)-methyltransferase

1996 • 96 citations

Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene

1996 • 90 citations

5-Aza-2'-deoxycytidine (Decitabine) induces trilineage response in unfavourable myelodysplastic syndromes.

1993 • 89 citations

Pilot study of 5-aza-2'-deoxycytidine (Decitabine) in the treatment of poor prognosis acute myelogenous leukemia patients: preliminary results.

1993 • 84 citations

A specific CpG methylation pattern of theMGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

1999 • 78 citations

Abnormal methylation of the calcitonin gene in human colonic neoplasms.

1989 • 75 citations

Epigenetic Gene Inactivation Induced by a Cis-acting Methylation Center

1995 • 71 citations

Structure, function and regulation of mammalian DNA methyltransferase

1993 • 63 citations

Cancer metastasis: negative regulation by an invasion-suppressor complex.

1995 • 61 citations

Microsatellite instability and mismatch repair defects in cancer cells

1996 • 44 citations

Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration

1998 • 38 citations

Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations

1998 • 28 citations

Plant genes: The genetics of epigenetics

1998 • 19 citations

In vitro and in vivo effects of 5-aza-2'-deoxycytidine (Decitabine) on clonogenic cells from acute myeloid leukemia patients.

1993 • 14 citations

Retention of unmethylated CpG island alleles in human diploid fibroblast x fibrosarcoma hybrids expressing high levels of DNA methyltransferase.

1996 • 9 citations

Hypermethylation of p15INK4B Gene in a Patient With Acute Myelogenous Leukemia Evolved From Paroxysmal Nocturnal Hemoglobinuria

1998 • 9 citations

Deleted Work

1955 • 0 citations