CpG islands as gene markers in the vertebrate nucleus

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

DNA methylation and the frequency of CpG in animal DNA

1980 • 1,146 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

1985 • 668 citations

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

1984 • 586 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1962 • 466 citations

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

1981 • 464 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

Promoters for housekeeping genes

1986 • 412 citations

Use of restriction enzymes to detect potential gene sequences in mammalian DNA

1987 • 387 citations

Rare Bases in Animal DNA

1970 • 375 citations

DNA methylation, biochemistry, and biological significance

1984 • 343 citations

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

1987 • 339 citations

Recurrent mutations in haemophilia A give evidence for CpG mutation hotspots

1986 • 277 citations

Structural analysis of the X-linked gene encoding human glucose 6-phosphate dehydrogenase.

1986 • 228 citations

The absence of detectable methylated bases in Drosophila melanogaster DNA

1982 • 211 citations

Variable patterns of total DNA and rDNA methylation in animals

1980 • 210 citations

Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene.

1987 • 201 citations

Methylated and unmethylated DNA compartments in the sea urchin genome

1979 • 195 citations

Long-range restriction site mapping of mammalian genomic DNA

1986 • 194 citations

Molecular Biology of DNA Methylation

1985 • 186 citations

Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis

1986 • 184 citations

Unmethlated domains in vertebrate DNA

1983 • 173 citations

Molecular biology of DNA methylation

1987 • 166 citations

Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

1986 • 164 citations

Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.

1986 • 157 citations

CG dinucleotide clusters in MHC genes and in 5′ demethylated genes

1984 • 146 citations

Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells.

1987 • 138 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Site specific demethylation in the promoter of human gamma-globin gene does not alleviate methylation mediated suppression.

1987 • 105 citations

Methylation of the mouse hprt gene differs on the active and inactive X chromosomes.

1986 • 105 citations

Neighboring base effects on substitution rates in pseudogenes.

1986 • 105 citations

Coincident start sites for divergent transcripts at a randomly selected CpG-rich island of mouse.

1987 • 98 citations

Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5′-flanking region contains hepatoma specific transcriptional signals.

1985 • 93 citations

Genetics by gel electrophoresis: the impact of pulsed field gel electrophoresis on mammalian genetics

1987 • 88 citations

Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island.

1987 • 79 citations

The maintenance of methylation-free islands in transgenic mice.

1986 • 70 citations

Trophic factor theory matures

1987 • 11 citations