Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

LNCaP model of human prostatic carcinoma.

1983 • 1,749 citations

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

1992 • 1,647 citations

Establishment and characterization of a human prostatic carcinoma cell line (PC-3).

1979 • 1,595 citations

Cancer statistics, 1994

1994 • 1,345 citations

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

1992 • 1,331 citations

Isolation of a human prostate carcinoma cell line (DU 145)

1978 • 1,176 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

DNA methylation and gene activity

1988 • 904 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.

1988 • 753 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

GLUTATHIONE S-TRANSFERASES: GENE STRUCTURE, REGULATION, AND BIOLOGICAL FUNCTION

1989 • 624 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Intraductal dysplasia: A premalignant lesion of the prostate

1986 • 584 citations

Glutathione Transferases and Cancer

1992 • 548 citations

The Role of Glutathione and Glutathione Transferases in Chemical Cardnogenesi

1990 • 466 citations

Allelic loss of chromosomes 16q and 10q in human prostate cancer.

1990 • 456 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Glutathione S-transferases, structure, regulation, and therapeutic implications

1993 • 409 citations

Rapid detection of inducers of enzymes that protect against carcinogens.

1992 • 395 citations

A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer

1986 • 382 citations

Isoenzyme(S) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study

1990 • 372 citations

DNA methylation and cancer

2002 • 319 citations

CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene.

1993 • 317 citations

High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.

1991 • 311 citations

Glutathione S-Transferases: Gene Structure and Regulation of Expression

1993 • 300 citations

DNA Methylation and Cancer

2000 • 266 citations

The Role of Dna Methylation in Cancer

1990 • 244 citations

Effect of regional DNA methylation on gene expression.

1985 • 232 citations

Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.

1991 • 207 citations

DNA Strand Breaks: the DNA Template Alterations That Trigger p53-Dependent DNA Damage Response Pathways

1994 • 198 citations

The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.

1988 • 197 citations

DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture.

1986 • 185 citations

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

1992 • 165 citations

Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.

1989 • 164 citations

An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue.

1990 • 157 citations

Epidemiologic evidence regarding predisposing factors to prostate cancer

1990 • 149 citations

Establishment of a New Prostatic Carcinoma Cell Line (TSU-PR1)

1987 • 149 citations

Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.

1988 • 134 citations

The structure of the human glutathione S-transferase π gene

1988 • 129 citations

Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man.

1985 • 121 citations

Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.

1985 • 99 citations

Structure of the human genomic glutathione S-transferase-π gene

1989 • 94 citations

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

1988 • 93 citations

Regulation of human glutathione S-transferase π gene transcription: influence of 5′-flanking sequences and trans-mactivating factors which recognize AP-1-binding sites

1990 • 63 citations

Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinoma

1989 • 62 citations

Glutathione transferase π its minimal promoter and downstream cis-acting element

1991 • 35 citations

Characterization of the Functional Gene and Several Processed Pseudogenes in the Human Triosephosphate Isomerase Gene Family

1985 • 24 citations