Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Number of CpG islands and genes in human and mouse.

1993 • 986 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

CpG islands as gene markers in the vertebrate nucleus

1987 • 687 citations

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

1985 • 668 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Alternative chromatin structure at CpG islands

1990 • 480 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.

1993 • 293 citations

In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.

1990 • 250 citations

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines.

1990 • 237 citations

Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene.

1987 • 201 citations

Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR.

1991 • 195 citations

Unmethlated domains in vertebrate DNA

1983 • 173 citations

Sex difference in methylation of single-copy genes in human meiotic germ cells: Implications for X chromosome inactivation, parental imprinting, and origin of CpG mutations

1990 • 161 citations

Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement.

1985 • 160 citations

Demethylation of CpG islands in embryonic cells

1991 • 151 citations

CG dinucleotide clusters in MHC genes and in 5′ demethylated genes

1984 • 146 citations

PCR amplification of long DNA fragments

1992 • 118 citations

A cis-acting element accounts for a conserved methylation pattern upstream of the mouse adenine phosphoribosyltransferase gene.

1993 • 78 citations

The functional domains of the murine Thy-1 gene promoter.

1991 • 77 citations

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

1990 • 76 citations

The maintenance of methylation-free islands in transgenic mice.

1986 • 70 citations

The methylation-free status of a housekeeping transgene is lost at high copy number

1990 • 63 citations

DNA hypomethylation and germ cell-specific expression of testis-specific H2B histone gene.

1991 • 62 citations

Chromatin Structure and Developmental Expression of the Human α-Globin Cluster

1986 • 50 citations

A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines

1989 • 44 citations

High-Pressure Ion Exchange Chromatography

1974 • 37 citations

Chromatin structure of the human dihydrofolate reductase gene promoter. Multiple protein-binding sites.

1986 • 32 citations

Identification of DNA sequences required for mouse APRT gene expression

1988 • 31 citations

Demethylation of Somatic and Testis-Specific Histone H2A and H2B Genes in F9 Embryonal Carcinoma Cells

1993 • 30 citations

In vitromethylation of CpG-rich islands

1989 • 26 citations

Region- and cell type-specific de novo DNA methylation in cultured mammalian cells

1991 • 26 citations

Cell type-specific interactions of transcription factors with a housekeeping promoterin vivo

1993 • 23 citations

Transcription factors binding to the mouse HTF9 housekeeping promoter differ between cell types

1991 • 19 citations

Differential methylation of a CpG‐island concatemer in hemi‐ and homozygous transgenic mice

1991 • 7 citations