Loss of methylation activates Xist in somatic but not in embryonic cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse

1975 • 783 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome

1991 • 617 citations

Characterization of a murine gene expressed from the inactive X chromosome

1991 • 529 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

Localization of the X inactivation centre on the human X chromosome in Xq13

1991 • 380 citations

Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

1993 • 369 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

Preferential expression of the maternally derived X chromosome in the mouse yolk sac

1977 • 328 citations

Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos

1979 • 284 citations

Evidence that random and imprinted Xist expression is controlled by preemptive methylation

1994 • 247 citations

Mammalian X-Chromosome Action: Inactivation Limited in Spread and in Region of Origin

1963 • 247 citations

Y-encoded, species-specific DNA in mice: Evidence that the Y chromosome exists in two polymorphic forms in inbred strains

1984 • 233 citations

Cell lineage-specific undermethylation of mouse repetitive DNA

1984 • 225 citations

mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation

1991 • 189 citations

Infectivity and methylation of retroviral genomes is correlated with expression in the animal

1981 • 165 citations

Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X–inactivation

1995 • 155 citations

The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end

1983 • 150 citations

CONTROL OF CHROMOSOME INACTIVATION

1975 • 144 citations

Biological Sciences: X Chromosome Inactivation studied by Injection of a Single Cell into the Mouse Blastocyst

1971 • 134 citations

Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells

1993 • 117 citations

Gamete–specific methylation correlates with imprinting of the murine Xist gene

1995 • 113 citations

Differentiation of X chromosomes in early female mouse embryos

1974 • 112 citations

Preferential paternal X inactivation in extraembryonic tissues of early mouse embryos

1982 • 109 citations

Timing of X-chromosome inactivation in postimplantation mouse embryos

1982 • 102 citations

Recognition of unusual DNA structures by human DNA(cytosine-5)methyltransferase

1991 • 100 citations

5-Azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mouse cell line

1982 • 94 citations

Center for Barr body condensation on the proximal part of the human Xq: a hypothesis

1974 • 93 citations

Allele-specific gene expression in mammals: the curious case of the imprinted RNAs.

1994 • 56 citations

Trisomy 21 for the region 21q223: Identification by high-resolution R-banding patterns

1981 • 48 citations

X chromosome reactivation in mouse embryonal carcinoma cells.

1985 • 42 citations

Non‐random X‐chromosome expression early in mouse development

1981 • 26 citations