Retention of unmethylated CpG island alleles in human diploid fibroblast x fibrosarcoma hybrids expressing high levels of DNA methyltransferase.

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

1991 • 3,422 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Spl elements protect a CpG island from de novo methylation

1994 • 713 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

MAMMALIAN X-CHROMOSOME INACTIVATION

1983 • 635 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation

1993 • 522 citations

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.

1993 • 493 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

1991 • 467 citations

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

1992 • 454 citations

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

1995 • 426 citations

Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.

1983 • 361 citations

Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation.

1984 • 305 citations

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1993 • 255 citations

The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.

1988 • 197 citations

DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture.

1986 • 185 citations

Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE

1994 • 167 citations

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

1992 • 165 citations

Implications of FRA16A Structure for the Mechanism of Chromosomal Fragile Site Genesis

1994 • 140 citations

Tumorigenicity of human HT1080 fibrosarcoma X normal fibroblast hybrids: chromosome dosage dependency.

1984 • 130 citations

Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.

1993 • 95 citations

Inhibition of promoter activity by methylation: possible involvement of protein mediators.

1991 • 88 citations

A cis-acting element accounts for a conserved methylation pattern upstream of the mouse adenine phosphoribosyltransferase gene.

1993 • 78 citations

Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia

1991 • 77 citations

Suppression of Gene Amplification in Human Cell Hybrids

1992 • 76 citations

DNA hypermethylation is associated with 17p allelic loss in neural tumors.

1993 • 75 citations

Epigenetic Gene Inactivation Induced by a Cis-acting Methylation Center

1995 • 71 citations

Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts.

1994 • 69 citations

Altered chromosome 6 in immortal human fibroblasts.

1992 • 63 citations

In vitro methylation of the promoter and enhancer of Pro alpha 1(I) collagen gene leads to its transcriptional inactivation

1991 • 59 citations

Molecular dissection of a contiguous gene syndrome: frequent submicroscopic deletions, evolutionarily conserved sequences, and a hypomethylated "island" in the Miller-Dieker chromosome region.

1989 • 59 citations

Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks.

1990 • 53 citations

Human Calcitonin gene regulation by helix-loop-nelix recognition sequences

1992 • 35 citations