Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers.

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction

1992 • 323 citations

Ca2+ influx following receptor activation

1991 • 187 citations

Excitement About Calcium Signaling in Inexcitable Cells

1993 • 187 citations

Pharmaceutical research in molecular oncology

1994 • 134 citations

L651582: A Novel Antiproliferative and Antimetastasis Agent

1990 • 132 citations

Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A).

1994 • 132 citations

Receptor‐mediated calcium entry

1990 • 127 citations

In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

1992 • 116 citations

The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.

1991 • 100 citations

Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma. An alternative mechanism for cholinergic-induced phosphoinositide breakdown.

1993 • 87 citations

The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582

1991 • 77 citations

Shifting the cancer paradigm: must we kill to cure?

1995 • 74 citations

Tyrosine protein kinase activity of the EGF receptor is required to induce activation of receptor-operated calcium channels

1989 • 36 citations

Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo

1995 • 12 citations

Drugs active against growth factor and oncogene phosphatidylinositol signalling pathways.

1992 • 9 citations