A hierarchical concept of cellular and subcellular Ca2+-signalling

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Handbook Of Biological Confocal Microscopy

2006 • 3,531 citations

Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle

1993 • 1,917 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Calcium signaling

1995 • 1,905 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Relaxation of Arterial Smooth Muscle by Calcium Sparks

1995 • 1,383 citations

Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone

1990 • 1,098 citations

Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors

1994 • 908 citations

Excitation-Contraction Coupling and Cardiac Contractile Force

1993 • 765 citations

Spiral Calcium Wave Propagation and Annihilation in Xenopus laevis Oocytes

1991 • 720 citations

Fluorescent Probes of Cell Signaling

1989 • 649 citations

Ryanodine modifies conductance and gating behavior of single Ca2+ release channel

1987 • 548 citations

Calcium sparks and [Ca2+]i waves in cardiac myocytes

1996 • 524 citations

Spontaneous transient outward currents in single visceral and vascular smooth muscle cells of the rabbit.

1986 • 461 citations

Local calcium transients triggered by single L-type calcium channel currents in cardiac cells

1995 • 452 citations

Structure and Development of E-C Coupling Units in Skeletal Muscle

1994 • 398 citations

Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes

1994 • 363 citations

Subcellular distribution of Ca2+ release channels underlying Ca2+ waves and oscillations in exocrine pancreas

1993 • 357 citations

Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes.

1995 • 345 citations

Superresolution Three-Dimensional Images of Fluorescence in Cells with Minimal Light Exposure

1995 • 345 citations

Subthreshold synaptic Ca2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons

1995 • 309 citations

Calcium and Hormone Action

1994 • 307 citations

Photolabile chelators for the rapid photorelease of divalent cations.

1988 • 295 citations

Two mechanisms of quantized calcium release in skeletal muscle

1996 • 295 citations

Control of Calcium Release in Functioning Skeletal Muscle Fibers

1994 • 293 citations

Imaging Elementary Events of Calcium Release in Skeletal Muscle Cells

1995 • 284 citations

Ratiometric confocal Ca2+-measurements with visible wavelength indicators in isolated cardiac myocytes

1993 • 244 citations

Relation Between the Sarcolemmal Ca ²⁺ Current and Ca ²⁺ Sparks and Local Control Theories for Cardiac Excitation-Contraction Coupling

1996 • 231 citations

Coupling of the Na+/Ca2+exchanger, Na+/K+ pump and sarcoplasmic reticulum in smooth muscle

1993 • 230 citations

Cellular origins of the transient inward current in cardiac myocytes. Role of fluctuations and waves of elevated intracellular calcium.

1989 • 223 citations

Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle.

1996 • 213 citations

Calcium waves in mammalian heart: quantification of origin, magnitude, waveform, and velocity

1990 • 209 citations

Localized All-or-None Calcium Liberation by Inositol Trisphosphate

1990 • 205 citations

Regulation of calcium release by calcium inside the sarcoplasmic reticulum in ventricular myocytes

1996 • 204 citations

Excitation-contraction coupling and cardiac contractile force

1992 • 190 citations

Submicroscopic calcium signals as fundamental events of excitation‐‐contraction coupling in guinea‐pig cardiac myocytes.

1996 • 182 citations

Regulation of the gating of the sheep cardiac sarcoplasmic reticulum ca2+-release channel by luminal Ca2+

1994 • 170 citations

Local, stochastic release of Ca2+ in voltage‐clamped rat heart cells: visualization with confocal microscopy.

1994 • 168 citations

Calcium concentration and movement in the diadic cleft space of the cardiac ventricular cell

1996 • 158 citations

Microscopic spiral waves reveal positive feedback in subcellular calcium signaling

1993 • 157 citations

Ca2+ sparks involving multiple Ca2+ release sites along Z‐lines in rat heart cells.

1996 • 148 citations

Ca2+ transients associated with openings of inositol trisphosphate‐gated channels in Xenopus oocytes.

1996 • 136 citations

Light-flash physiology with synthetic photosensitive compounds.

1987 • 133 citations

Modulation of Ca2+ release in cultured neonatal rat cardiac myocytes. Insight from subcellular release patterns revealed by confocal microscopy.

1994 • 120 citations

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp

1995 • 119 citations

Excitation-contraction coupling in mammalian cardiac cells

1992 • 118 citations

Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes.

1995 • 116 citations

Detection of changes in near-membrane Ca2+ concentration using a novel membrane-associated Ca2+ indicator

1994 • 104 citations

Release of intracellular calcium and modulation of membrane currents by caffeine in bull‐frog sympathetic neurones.

1992 • 104 citations

Subcellular Ca2+ signals underlying waves and graded responses in HeLa cells

1996 • 103 citations

Flash photolysis of caged compounds: New tools for cellular physiology

1989 • 103 citations

Localization of the site of Ca2 + release at the level of a single sarcomere in skeletal muscle fibres

1994 • 98 citations

Spatially non‐uniform Ca2+ signals induced by the reduction of transverse tubules in citrate‐loaded guinea‐pig ventricular myocytes in culture.

1996 • 93 citations

Video-Rate Confocal Microscopy

1995 • 91 citations

Pulsed laser imaging of rapid Ca2+ gradients in excitable cells

1994 • 85 citations

Agonist-induced [Ca2+]i waves and Ca(2+)-induced Ca2+ release in mammalian vascular smooth muscle cells

1992 • 84 citations

Visualization of Quantal Synaptic Transmission by Dendritic Calcium Imaging

1994 • 81 citations

Partial Inhibition of Ca ²⁺ Current by Methoxyverapamil (D600) Reveals Spatial Nonuniformities in [Ca ²⁺ ] _i During Excitation-Contraction Coupling in Cardiac Myocytes

1995 • 68 citations

Efficacy of peak Ca2+ currents (ICa) as trigger of sarcoplasmic reticulum Ca2+ release in myocytes from the guinea‐pig coronary artery.

1995 • 67 citations

Ca2+-induced Ca2+ Release in Neurones.

1994 • 66 citations

Simultaneous recording of Indo‐1 flourescence and Na⁺/Ca²⁺ exchange current reveals two components of Ca²⁺‐release from sarcoplasmic reticulum of cardiac atrial myocytes

1990 • 65 citations

Ca2+ influx modulation of temporal and spatial patterns of inositol trisphosphate‐mediated Ca2+ liberation in Xenopus oocytes.

1994 • 63 citations

Quantal Ca2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores

1994 • 58 citations

Control of action potential propagation by intracellular Ca2+ in cultured rat dorsal root ganglion cells.

1996 • 57 citations

Lumenal Sites and C Terminus Accessibility of the Skeletal Muscle Calcium Release Channel (Ryanodine Receptor)

1995 • 53 citations

Single calcium channel currents of arterial smooth muscle at physiological calcium concentrations

1992 • 53 citations

Photolysis of caged compounds characterized by ratiometric confocal microscopy: a new approach to homogeneously control and measure the calcium concentration in cardiac myocytes

1996 • 51 citations

Transition from circular to linear rotation of a vortex in an excitable cellular medium

1990 • 49 citations

Spontaneous miniature outward currents in cultured bullfrog neurons

1987 • 46 citations

Diffusion around a cardiac calcium channel and the role of surface bound calcium

1991 • 44 citations

Detection of Ca²⁺‐transients elicited by flash photolysis of DM‐nitrophen with a fast calcium indicator

1995 • 42 citations

Detection of a trigger zone of bradykinin-induced fast calcium waves in PC12 neurites

1996 • 42 citations

A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths

1994 • 38 citations

Inositol triphosphate produces different patterns of cytoplasmic Ca²⁺ spiking depending on its concentration

1991 • 36 citations

Optical modifications enabling simultaneous confocal imaging with dyes excited by ultraviolet‐ and visible‐wavelength light

1993 • 31 citations

Perturbation of sarcoplasmic reticulum calcium release and phenol red absorbance transients by large concentrations of fura-2 injected into frog skeletal muscle fibers.

1990 • 27 citations

Subcellular features of calcium signalling in heart muscle: What do we learn?

1995 • 27 citations

The role of curvature and pulse width for transition to unstable wave fronts in the Belousov–Zhabotinsky reaction

1992 • 23 citations

Subcellular restricted spaces: significance for cell signalling and excitation-contraction coupling

1993 • 21 citations

Subcellular properties of triggered Ca2+ waves in isolated citrate‐loaded guinea‐pig atrial myocytes characterized by ratiometric confocal microscopy.

1996 • 19 citations

Direct View Confocal Imaging Systems Using a Slit Aperture

1995 • 13 citations

Subcellular Localization of Calcium Release in Isolated Rat Myocardial Cells

1991 • 3 citations

Subcellular Localization of Calcium Release in Isolated Rat Myocardial Cells

1991 • 1 citations