Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Intracellular pH.

1981 • 2,440 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

1995 • 1,892 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

1989 • 1,616 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Capacitative calcium entry

1995 • 1,112 citations

Decoding of cytosolic calcium oscillations in the mitochondria

1995 • 1,090 citations

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

1992 • 920 citations

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

1993 • 752 citations

Calcium release‐activated calcium current in rat mast cells.

1993 • 729 citations

Mitochondrial calcium transport: physiological and pathological relevance

1994 • 702 citations

Mitochondrial Participation in the Intracellular Ca2+ Network

1997 • 556 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells

1993 • 505 citations

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons

1994 • 494 citations

Potassium and Calcium Channels in Lymphocytes

1995 • 488 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins

1994 • 430 citations

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes

1995 • 425 citations

Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro.

1990 • 410 citations

Receptor-activated Ca2+ influx: how many mechanisms for how many channels?

1994 • 403 citations

Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.

1989 • 402 citations

Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.

1995 • 370 citations

Dominant Role of Mitochondria in Clearance of Large Ca2+ Loads from Rat Adrenal Chromaffin Cells

1996 • 352 citations

The Sodium‐Induced Efflux of Calcium from Heart Mitochondria

1976 • 350 citations

A Reevaluation of the Role of Mitochondria in Neuronal Ca²⁺ Homeostasis

1996 • 347 citations

Mitochondrial Ca2+ homeostasis in intact cells.

1994 • 320 citations

Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium

1995 • 299 citations

An FCCP-sensitive Ca2+ store in bullfrog sympathetic neurons and its participation in stimulus-evoked changes in [Ca2+]i

1994 • 262 citations

The calcium current activated by T cell receptor and store depletion in human lymphocytes is absent in a primary immunodeficiency.

1994 • 256 citations

Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.

1996 • 247 citations

Intracellular calcium dependence of gene expression in single T lymphocytes.

1994 • 244 citations

Slow Calcium-dependent Inactivation of Depletion-activated Calcium Current. STORE-DEPENDENT AND -INDEPENDENT MECHANISMS

1995 • 234 citations

Mitochondrial outer membrane contains a protein producing nonspecific diffusion channels.

1980 • 214 citations

Physiological role of mitochondrial Ca2+ transport

1994 • 209 citations

A Role for Calcium Influx in the Regulation of Mitochondrial Calcium in Endothelial Cells

1996 • 183 citations

Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes.

1994 • 181 citations

Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.

1995 • 179 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Calcium influx and its control by calcium release

1993 • 167 citations

Calcium fluxes in T lymphocytes.

1992 • 133 citations

Reassessment of fura-2 and the ratio method for determination of intracellular Ca2+ concentrations

1991 • 116 citations

Imaging early steps of human T cell activation by antigen-presenting cells.

1992 • 108 citations

Release of intracellular calcium and modulation of membrane currents by caffeine in bull‐frog sympathetic neurones.

1992 • 104 citations

Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange

1993 • 102 citations

Ca2+ clearance mechanisms in isolated rat adrenal chromaffin cells.

1996 • 95 citations

Modulation of Ca2+ influx dependent on store depletion by intracellular adenine-guanine nucleotide levels.

1994 • 87 citations

Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.

1995 • 85 citations

Plasmacytoid T cells: A cell population normally present in the reactive lymph node

1988 • 82 citations

Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions

1995 • 79 citations

Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ stores

1994 • 67 citations

Lymphocyte capping and lymphocyte migration as associated events in the in vivo antigen trapping process. an electron-microscopic autoradiographic study in the spleen of mice

1975 • 52 citations

ATP depletion inhibits capacitative Ca2+ entry in rat thymic lymphocytes

1995 • 50 citations

Mitochondrial free Ca2+ concentration in living cells

1994 • 43 citations

The effect of mitochondrial inhibitors on calcium homeostasis in tumor mast cells

1990 • 39 citations

FCCP releases Ca2+ from a non-mitochondrial store in an identifiedHelisoma neuron

1991 • 36 citations

Kinetics of calcium transport across the lymphocyte plasma membrane

1993 • 36 citations

Is there a Na+/Ca2+ exchanger in macrophages and in lymphocytes?

1993 • 32 citations

Intracellular ADP Modulates the Ca Release-activated Ca Current in a Temperature- and Ca -dependent Way

1996 • 23 citations

Elektronenmikroskopische und immunhistochemische Untersuchungen an menschlichen Lymphozyten

1976 • 7 citations