Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

1992 • 724 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors

1993 • 663 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

1992 • 368 citations

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1992 • 367 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

A reappraisal of non-consensus mRNA splice sites

1991 • 324 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

1991 • 297 citations

General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 • 286 citations

Mutations in U6 snRNA that Alter Splice Site Specificity: Implications for the Active Site

1993 • 283 citations

Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.

1992 • 273 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites

1992 • 268 citations

Involvement of U6 snRNA in 5′ Splice Site Selection

1993 • 265 citations

Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.

1993 • 243 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Alternative mRNA Splicing

1992 • 219 citations

Pre-mRNA Splicing in Yeast

1989 • 209 citations

Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ASF.

1993 • 192 citations

Functional domains of the human splicing factor ASF/SF2.

1993 • 188 citations

Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.

1988 • 163 citations

Who's on first? The U1 snRNP-5 splice site interaction and splicing

1991 • 156 citations

The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.

1992 • 154 citations

Are vertebrate exons scanned during splice-site selection?

1992 • 141 citations

U1-Specific Protein C needed for Efficient Complex Formation of U1 snRNP with a 5′ Splice Site

1990 • 135 citations

Evidence for an essential non-Watson–Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron

1993 • 133 citations

Splicing Takes a Holliday

1992 • 109 citations

Precision and orderliness in splicing

1987 • 104 citations

Retroviral Insertions Downstream of the Heterogeneous Nuclear Ribonucleoprotein Al Gene in Erythroleukemia Cells: Evidence that Al Is Not Essential for Cell Growth

1992 • 79 citations

A Sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA.

1990 • 69 citations

Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth.

1992 • 40 citations

Influences of separation and adjacent sequences on the use of alternative 5′ splice sites

1991 • 32 citations