A Novel Protein Factor Is Required for Use of Distal Alternative 5' Splice Sites In Vitro

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

1978 • 1,117 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

PRE-mRNA SPLICING

1986 • 673 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

A mechanism for RNA splicing.

1980 • 553 citations

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators

1991 • 508 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

Sex in flies: the splice of life

1989 • 468 citations

Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins

1988 • 461 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.

1990 • 359 citations

Primary structure of the human splicing factor asf reveals similarities with drosophila regulators

1991 • 357 citations

Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site

1982 • 353 citations

Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript

1990 • 333 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

An RNA Processing Activity That Debranches RNA Lariats

1985 • 300 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Transcription and RNA processing by the DNA tumour viruses

1980 • 228 citations

On/off regulation of gene expression at the level of splicing

1988 • 186 citations

Regulation of the appearance of cytoplasmic RNAs from region 1 of the adenovirus 2 genome

1978 • 184 citations

The sex determination locus transformer-2 of Drosophila encodes a polypeptide with similarity to RNA binding proteins

1989 • 156 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

Developmental expression of a regulatory gene is programmed at the level of splicing.

1987 • 143 citations

Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.

1987 • 142 citations

Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.

1988 • 115 citations

A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties.

1987 • 95 citations

Splicing of adenovirus 2 early region 1A mRNAs is non-sequential

1983 • 83 citations

Alternative splicing of E1A transcripts of adenovirus requires appropriate ionic conditions in vitro

1987 • 77 citations

Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products

1987 • 70 citations

In vitro splicing of adenovirus E1A transcripts: characterization of novel reactions and of multiple branch points abnormally far from the 3′ splice site

1988 • 50 citations

Factors Influencing Alternative Splice Site Utilization In Vivo

1987 • 48 citations

Evidence for nuclear factors involved in recognition of 5′ splice sites

1989 • 43 citations

Three distinct activities possibly involved in mRNA splicing are found in a nuclear fraction lacking U1 and U2 RNA

1986 • 32 citations

Short Donor Site Sequences Inserted within the Intron of β-Globin Pre-mRNA Serve for Splicing In Vitro

1988 • 16 citations

Multiple cis-Acting Sequence Elements Are Required for Efficient Splicing of Simian Virus 40 Small-t Antigen Pre-mRNA

1988 • 10 citations