Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Precision mapping of quantitative trait loci.

1994 • 3,191 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci.

1993 • 1,112 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo

1999 • 1,066 citations

Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells

2002 • 1,027 citations

Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells

2002 • 986 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

Cell interactions in the induction of tolerance: the role of thymic lymphocytes.

1970 • 920 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor β

1995 • 868 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

1996 • 770 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

2002 • 756 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

1985 • 721 citations

Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells

2002 • 704 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

2003 • 644 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

IL-2, Regulatory T Cells, and Tolerance

2004 • 566 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1969 • 554 citations

A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood

2001 • 540 citations

B cells and professional APCs recruit regulatory T cells via CCL4

2001 • 496 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus

1996 • 449 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

The nature and identification of quantitative trait loci: a community's view

2003 • 426 citations

Natural Killer Cells Activated by MHC Class ILow Targets Prime Dendritic Cells to Induce Protective CD8 T Cell Responses

2003 • 416 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

CD4+CD25+ Regulatory T Cells Control the Severity of Viral Immunoinflammatory Lesions

2004 • 357 citations

Dendritic Cells Mediate NK Cell Help for Th1 and CTL Responses: Two-Signal Requirement for the Induction of NK Cell Helper Function

2003 • 347 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

T-cell function in newborn mice and humans

1999 • 326 citations

The main function of IL-2 is to promote the development of T regulatory cells

2003 • 323 citations

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.

1982 • 321 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

Structural basis of the endoproteinase–protein inhibitor interaction

2000 • 283 citations

Genetic susceptibility to post-thymectomy autoimmune diseases in mice

1981 • 265 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

Association of a putative regulatory polymorphism in the PD‐1 gene with susceptibility to type 1 diabetes

2003 • 227 citations

Development and function of CD25+CD4+ regulatory T cells

2004 • 220 citations

The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells

2003 • 203 citations

Epistatic Modifiers of Autoimmunity in a Murine Model of Lupus Nephritis

1999 • 200 citations

Organ‐specific Autoimmunity Induced by Lymphopenia

1996 • 194 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

Facilitation of β Selection and Modification of Positive Selection in the Thymus of Pd-1–Deficient Mice

2000 • 181 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

Spontaneous thyroiditis in thymectomized and irradiated Wistar rats.

1973 • 179 citations

A Role for Cathepsin L and Cathepsin S in Peptide Generation for MHC Class II Presentation

2002 • 175 citations

Turnover and Proliferation of NK Cells in Steady State and Lymphopenic Conditions

2004 • 172 citations

Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance.

1987 • 166 citations

Association of the PD‐1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope

2004 • 165 citations

Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors

2000 • 153 citations

New Genetic Loci That Control Susceptibility and Symptoms of Experimental Allergic Encephalomyelitis in Inbred Mice

1998 • 151 citations

Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity.

1996 • 149 citations

Identification of Bphs , an Autoimmune Disease Locus, as Histamine Receptor H ₁

2002 • 149 citations

Development of the Dendritic Cell System during Mouse Ontogeny

2004 • 146 citations

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

2002 • 143 citations

Diversity of NK Cell Receptor Repertoire in Adult and Neonatal Mice

1999 • 143 citations

Congenic Mapping of the Type 1 Diabetes Locus,Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping

2000 • 140 citations

Tolerance mechanism in experimental ovarian and gastric autoimmune diseases.

1992 • 134 citations

Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase- reactive T cells

1999 • 129 citations

Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes.

1980 • 125 citations

Development of Neonatal Th1/Th2 Function

2000 • 125 citations

A zona pellucida 3 peptide vaccine induces antibodies and reversible infertility without ovarian pathology.

1995 • 124 citations

Origin and differentiation of natural killer cells. II. Functional and morphologic studies of purified NK-1.1+ cells.

1986 • 121 citations

Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology.

1987 • 117 citations

Acquisition of anergic and suppressive activities in transforming growth factor- -costimulated CD4+CD25- T cells

2004 • 116 citations

Autoimmunity : physiology and disease

1993 • 111 citations

NK Cells Stimulate Proliferation of T and NK Cells through 2B4/CD48 Interactions

2004 • 109 citations

Ontogeny of T cell tolerance to peripherally expressed antigens

1999 • 107 citations

TGF regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo

2004 • 106 citations

Thyroiditis in T cell-depleted rats: suppression of the autoallergic response by reconstitution with normal lymphoid cells.

1976 • 106 citations

Fingerprints of anergic T cells

2001 • 104 citations

A Mouse Gene Encoding an Oocyte Antigen Associated with Autoimmune Premature Ovarian Failure

1999 • 104 citations

Specific role for cathepsin S in the generation of antigenic peptidesin vivo

2002 • 104 citations

Natural and Engineered Disorders of Lymphocyte Development

1998 • 102 citations

Experimental allergic orchitis in mice

1981 • 100 citations

The regulation of lymphocyte activation by inhibitory receptors

2004 • 98 citations

Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy.

1991 • 96 citations

Autoimmune oophoritis in thymectomized mice: T cell requirement in adoptive cell transfer.

1980 • 95 citations

The Ability of B Cells and Dendritic Cells to Present Antigen Increases During Ontogeny

2000 • 92 citations

Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells.

1996 • 92 citations

CD4+CD25+ T-cell development is regulated by at least 2 distinct mechanisms

2002 • 90 citations

T-Cell-Mediated Autoimmunity

2003 • 85 citations

Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.

1993 • 85 citations

Cutting Edge: Expression of Functional CD94/NKG2A Inhibitory Receptors on Fetal NK1.1+Ly-49− Cells: A Possible Mechanism of Tolerance During NK Cell Development

1999 • 84 citations

Persistence of Physiological Self Antigen Is Required for the Regulation of Self Tolerance

2000 • 83 citations

Effects of the multiple sclerosis associated −330 promoter polymorphism in IL2 allelic expression

2004 • 80 citations

Immune Responses to Ro60 and Its Peptides in Mice. I. The Nature of the Immunogen and Endogenous Autoantigen Determine the Specificities of the Induced Autoantibodies

1999 • 78 citations

T cell peptide of a self-protein elicits autoantibody to the protein antigen. Implications for specificity and pathogenetic role of antibody in autoimmunity.

1993 • 73 citations

DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

2000 • 71 citations

Genetics and molecular genetics of the MHC.

1999 • 68 citations

Gender, Age, and Season at Immunization Uniquely Influence the Genetic Control of Susceptibility to Histopathological Lesions and Clinical Signs of Experimental Allergic Encephalomyelitis

2004 • 64 citations

Cutting Edge: Homologous Recombination of the MHC Class I K Region Defines New MHC-Linked Diabetogenic Susceptibility Gene(s) in Nonobese Diabetic Mice

1999 • 64 citations

Quantitative trait loci for estrogen-dependent pituitary tumor growth in the rat

1997 • 63 citations

Allelic expression and interleukin-2 polymorphisms in multiple sclerosis

2001 • 63 citations

Origin and differentiation of natural killer cells

1986 • 59 citations

The elusive case for a role of mimicry in autoimmune diseases

2003 • 53 citations

Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3.

1996 • 52 citations

Self-tolerance and localized autoimmunity

1990 • 52 citations

Retargeting T Cell-Mediated Inflammation: A New Perspective on Autoantibody Action

2000 • 51 citations

Maternal Autoantibody Triggers De Novo T Cell-Mediated Neonatal Autoimmune Disease

2003 • 50 citations

Transferrin Receptor Expression as a Marker of Immature Cycling Thymocytes in the Mouse

1994 • 50 citations

Interacting Quantitative Trait Loci Control Phenotypic Variation in Murine Estradiol-Regulated Responses*

1999 • 49 citations

Intestinal parasitism terminates self tolerance and enhances neonatal induction of autoimmune disease and memory

2001 • 48 citations

A Major Linkage Region on Distal Chromosome 4 Confers Susceptibility to Mouse Autoimmune Gastritis

1999 • 48 citations

DR, DQ, and you: MHC alleles and autoimmunity

2001 • 47 citations

Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 46 citations

Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis.

1995 • 46 citations

Rapid induction of autoantibodies by endogenous ovarian antigens and activated T cells: implication in autoimmune disease pathogenesis and B cell tolerance.

1996 • 42 citations

Endogenous Oocyte Antigens Are Required for Rapid Induction and Progression of Autoimmune Ovarian Disease Following Day-3 Thymectomy

2001 • 42 citations

Neonatal Injection of an Ovarian Peptide Induces Autoimmune Ovarian Disease in Female Mice: Requirement of Endogenous Neonatal Ovaries

1997 • 42 citations

Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16.

1995 • 42 citations

Neonatal injection of native proton pump antigens induces autoimmune gastritis in mice

1997 • 41 citations

Constitutive expression of bcl-2 in B cells causes a lethal form of lupuslike autoimmune disease after induction of neonatal tolerance to H-2b alloantigens.

1996 • 39 citations

Regulatory T‐cell, endogenous antigen and neonatal environment in the prevention and induction of autoimmune disease

2001 • 39 citations

Ontogeny of murine macrophages: functions related to antigen presentation

1982 • 37 citations

Experimental allergic orchitis in mice

1985 • 36 citations

Genetic Analysis of Autoimmune Sialadenitis in Nonobese Diabetic Mice: A Major Susceptibility Region on Chromosome 1

2002 • 35 citations

Mechanism of Self-Tolerance and Events Leading to Autoimmune Disease and Autoantibody Response

1994 • 34 citations

An Interval Tightly Linked to but Distinct From the H2 Complex Controls Both Overt Diabetes (Idd16) and Chronic Experimental Autoimmune Thyroiditis (Ceat1) in Nonobese Diabetic Mice

2002 • 33 citations

Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (Lmp-2).

1993 • 31 citations

Induction of Diabetes in PVG/c Strain Rats by Manipulation of the Immune System

1990 • 28 citations

Autoimmune ovarian disease: mechanism of disease induction and prevention

1997 • 28 citations

Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain

1993 • 27 citations

Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses

2001 • 27 citations

A Mouse Gene Encoding an Oocyte Antigen Associated with Autoimmune Premature Ovarian Failure

1999 • 24 citations

Genetically modified animals and immunodeficiency

1993 • 24 citations

Requirements of NK Cells and Proinflammatory Cytokines in T Cell-Dependent Neonatal Autoimmune Ovarian Disease Triggered by Immune Complex

2004 • 24 citations

Transient T and B cell activation after neonatal induction of tolerance to MHC class II or Mls alloantigens.

1991 • 23 citations

Aod1Controlling Day 3 Thymectomy-Induced Autoimmune Ovarian Dysgenesis in Mice Encompasses Two Linked Quantitative Trait Loci with Opposing Allelic Effects on Disease Susceptibility

2003 • 23 citations

Interacting Quantitative Trait Loci Control Phenotypic Variation in Murine Estradiol-Regulated Responses

1999 • 23 citations

Autoimmune polyglandular syndrome type 1 and the autoimmune regulator

2004 • 20 citations

Congenic Mapping and Candidate Sequencing of Susceptibility Genes for Type 1 Diabetes in the NOD Mouse

2003 • 19 citations

Activating Ly-49D NK receptors: expression and function in relation to ontogeny and Ly-49 inhibitor receptors

2000 • 17 citations

Interacting Quantitative Trait Loci Control Loss of Peripheral Tolerance and Susceptibility to Autoimmune Ovarian Dysgenesis After Day 3 Thymectomy in Mice

2002 • 17 citations

Glutamine and tetrapeptide repeat variations affect the biological activity of different mouse interleukin‐2 alleles

1996 • 16 citations

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

2002 • 15 citations

Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice

2002 • 12 citations

Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase- reactive T cells

1999 • 12 citations

Genetic Dissection of Type 1 Diabetes Susceptibility Gene, Idd3, by Ancestral Haplotype Congenic Mapping

2002 • 10 citations

HIGH EXPRESSION IN BACTERIA AND PURIFICATION OF POLYMORPHIC MOUSE INTERLEUKIN 2 MOLECULES

1998 • 7 citations

Suppression of natural killer cell activity in infant mice occurs after target cell binding.

1995 • 6 citations

Regulatory T cells

2001 • 6 citations

HK-ATPase Expression in the Susceptible BALB/c and the Resistant DBA/2 Strains of Mice to Autoimmune Gastritis

2003 • 4 citations

Deleted Work

1955 • 0 citations