The regulation of lymphocyte activation by inhibitory receptors

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants

2002 • 3,274 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

IgG Fc Receptors

2001 • 1,667 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

2003 • 1,255 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Anti-inflammatory Activity of IVIG Mediated Through the Inhibitory Fc Receptor

2001 • 1,037 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

2003 • 816 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

2002 • 756 citations

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

2003 • 665 citations

Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

2003 • 644 citations

The Interaction Properties of Costimulatory Molecules Revisited

2002 • 640 citations

In vivo developmental stages in murine natural killer cell maturation

2002 • 588 citations

Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength

2002 • 497 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.

2003 • 481 citations

B7S1, a Novel B7 Family Member that Negatively Regulates T Cell Activation

2003 • 407 citations

B7x: A widely expressed B7 family member that inhibits T cell activation

2003 • 380 citations

Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants

2002 • 375 citations

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

2003 • 373 citations

Colony-Stimulating Factor-1-Dependent Macrophages Are Responsible for IVIG Protection in Antibody-Induced Autoimmune Disease

2003 • 300 citations

Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

2003 • 285 citations

Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity

2003 • 274 citations

B7-H1 pathway and its role in the evasion of tumor immunity

2003 • 272 citations

A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition

2002 • 257 citations

Reconstitution of NK cell receptor repertoire followingHLA-matched hematopoietic cell transplantation

2003 • 256 citations

Genetic Control of Human NK Cell Repertoire

2002 • 249 citations

Crucial Role of DNA Methylation in Determination of Clonally Distributed Killer Cell Ig-like Receptor Expression Patterns in NK Cells

2002 • 241 citations

The RasGAP-Binding Protein p62dok Is a Mediator of Inhibitory FcγRIIB Signals in B Cells

2000 • 238 citations

Association of a putative regulatory polymorphism in the PD‐1 gene with susceptibility to type 1 diabetes

2003 • 227 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

SHIP Recruitment Attenuates FcγRIIB-Induced B Cell Apoptosis

1999 • 220 citations

DNA Methylation Maintains Allele-specific KIR Gene Expression in Human Natural Killer Cells

2003 • 207 citations

IFN-γ protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism

2002 • 184 citations

Role of the rasGAP-associated docking protein p62^dokin negative regulation of B cell receptor-mediated signaling

2000 • 178 citations

Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2

2003 • 174 citations

A novel polymorphism in the Fcγ receptor IIB (CD32B) transmembrane region alters receptor signaling

2003 • 173 citations

Viral and Bacterial Infections Induce Expression of Multiple NK Cell Receptors in Responding CD8+ T Cells

2002 • 164 citations

Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4+ T Cells Independent of the PD-1 Receptor

2003 • 157 citations

RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells.

1996 • 152 citations

B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism

2003 • 141 citations

IFN-γ protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism

2002 • 139 citations

Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2

2003 • 136 citations

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb

2003 • 133 citations

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions

2004 • 129 citations

Natural Killer Cell Inhibitory Receptors Block Actin Cytoskeleton-dependent Recruitment of 2B4 (CD244) to Lipid Rafts

2002 • 126 citations

TCR Specificity Dictates CD94/NKG2A Expression by Human CTL

2002 • 126 citations

KIR2DL4 (CD158d) Genotype Influences Expression and Function in NK Cells

2003 • 123 citations

Negative Regulation of T Cell Receptor–Lipid Raft Interaction by Cytotoxic T Lymphocyte–associated Antigen 4

2003 • 122 citations

IVIg-mediated amelioration of murine ITP via FcγRIIB is independent of SHIP1, SHP-1, and Btk activity

2003 • 121 citations

Domain Shuffling Has Been the Main Mechanism Forming New Hominoid Killer Cell Ig-Like Receptors

2004 • 118 citations

Identification of a human member of the Ly-49 multigene family

1998 • 112 citations

Essential Role of Fcγ Receptors in Anti-Type II Collagen Antibody-Induced Arthritis

2003 • 111 citations

Cutting Edge: T Cell Migration Regulated by CXCR4 Chemokine Receptor Signaling to ZAP-70 Tyrosine Kinase

2001 • 107 citations

Surface Cytotoxic T Lymphocyte–associated Antigen 4 Partitions Within Lipid Rafts and Relocates to the Immunological Synapse under Conditions of Inhibition of T Cell Activation

2002 • 106 citations

Cross-linking the B7 Family Molecule B7-DC Directly Activates Immune Functions of Dendritic Cells

2002 • 104 citations

Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration

2002 • 101 citations

Iris Pigment Epithelium Expressing CD86 (B7-2) Directly Suppresses T Cell Activation In Vitro via Binding to Cytotoxic T Lymphocyte–associated Antigen 4

2003 • 98 citations

Cutting Edge: Both Activating and Inhibitory Fc Receptors Expressed on Mast Cells Regulate Experimental Allergic Encephalomyelitis Disease Severity

2003 • 93 citations

Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP-2) Can Play a Direct Role in the Inhibitory Function of Killer Cell Ig-Like Receptors in Human NK Cells

2003 • 92 citations

Cutting Edge: Molecular Cloning of a Killer Cell Ig-Like Receptor in the Mouse and Rat

2003 • 80 citations

Preferential Survival of CD8 T and NK Cells Expressing High Levels of CD94

2003 • 78 citations

Distinct Role of ZAP-70 and Src Homology 2 Domain-Containing Leukocyte Protein of 76 kDa in the Prolonged Activation of Extracellular Signal-Regulated Protein Kinase by the Stromal Cell-Derived Factor-1α/CXCL12 Chemokine

2003 • 76 citations

Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells

2003 • 69 citations

The D0 Domain of KIR3D Acts as a Major Histocompatibility Complex Class I Binding Enhancer

2002 • 69 citations

A full complement of receptors in immune complex diseases

2002 • 68 citations

Role That Each NKG2A Immunoreceptor Tyrosine-Based Inhibitory Motif Plays in Mediating the Human CD94/NKG2A Inhibitory Signal

2002 • 67 citations

Spontaneous Clustering and Tyrosine Phosphorylation of NK Cell Inhibitory Receptor Induced by Ligand Binding

2003 • 67 citations

Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to Chromosome X

2003 • 66 citations

FcγRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease

2003 • 65 citations

The etiology of autoimmune diabetes and thyroiditis: evidence for common genetic susceptibility

2003 • 65 citations

The Inhibitory Receptor FcγRII Reduces Joint Inflammation and Destruction in Experimental Immune Complex-Mediated Arthritides Not Only by Inhibition of FcγRI/III but Also by Efficient Clearance and Endocytosis of Immune Complexes

2003 • 61 citations

A Peptide from Heat Shock Protein 60 Is the Dominant Peptide Bound To Qa-1 in the Absence of the MHC Class Ia Leader Sequence Peptide Qdm

2003 • 61 citations

CD94/NKG2 Expression Does Not Inhibit Cytotoxic Function of Lymphocytic Choriomeningitis Virus-Specific CD8+ T Cells

2002 • 59 citations

Different and Divergent Regulation of the KIR2DL4 and KIR3DL1 Promoters

2003 • 55 citations

Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction

2002 • 50 citations

Differential Expression of the Inhibitory IgG Fc Receptor FcγRIIB on Germinal Center Cells: Implications for Selection of High-Affinity B Cells

2002 • 49 citations

Molecular Mechanism of the Activation-Induced Cell Death Inhibition Mediated by a p70 Inhibitory Killer Cell Ig-Like Receptor in Jurkat T Cells

2002 • 49 citations

Deletion of the Fcγ Receptor IIb in Thymic Stromal Lymphopoietin Transgenic Mice Aggravates Membranoproliferative Glomerulonephritis

2003 • 38 citations

Kim, S. et al. In vivo developmental stages in murine natural killer cell maturation. Nat. Immunol. 3, 523-528

2002 • 38 citations

Roles of FcγRIIB in Nasal Eosinophilia and IgE Production in Murine Allergic Rhinitis

2003 • 37 citations

Intravenous immunoglobulin modulates lymphocyte CD54 and monocyte FcγRII expression in patients with chronic inflammatory neuropathies

2003 • 36 citations

FcγRIIB activation leads to inhibition of signalling by independently ligated receptors

2003 • 35 citations

Allelic Variation in the Ectodomain of the Inhibitory Ly-49G2 Receptor Alters Its Specificity for Allogeneic and Xenogeneic Ligands

2002 • 31 citations

Human CD94 Gene Expression: Dual Promoters Differing in Responsiveness to IL-2 or IL-15

2003 • 27 citations

Cutting Edge: Stimulation with the Cognate Self-Antigen Induces Expression of the Ly49A Receptor on Self-Reactive T Cells Which Modulates Their Responsiveness

2003 • 7 citations

B6 Strain Ly49I Inhibitory Gene Expression on T Cells in FVB.Ly49IB6 Transgenic Mice Fails to Prevent Normal T Cell Functions

2002 • 4 citations