Immune Responses to Ro60 and Its Peptides in Mice. I. The Nature of the Immunogen and Endogenous Autoantigen Determine the Specificities of the Induced Autoantibodies

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

Manual of Clinical Laboratory Immunology

1992 • 1,243 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.

1988 • 871 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus

1969 • 499 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Antibodies to cellular antigens in Sjögren's syndrome.

1975 • 431 citations

Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity.

1995 • 338 citations

Epitope spreading

1996 • 302 citations

The lupus autoantigens and the pathogenesis of systemic lupus erythematosus

1986 • 259 citations

Differentiation of antinuclear antibodies giving speckled staining patterns in immunofluorescence

1972 • 238 citations

Resolution of the identity of certain antigen‐antibody systems in systemic lupus erythematosus and sjögren's syndrome: An interlaboratory collaboration

1979 • 219 citations

Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A).

1995 • 188 citations

Immunization with a Peptide Surrogate for Double-stranded DNA (dsDNA) Induces Autoantibody Production and Renal Immunoglobulin Deposition

1998 • 186 citations

Physical Association of Two Nuclear Antigens and Mutual Occurrence of Their Antibodies: The Relationship of the Sm and Rnaprotein (MO) Systems in Sle Sera

1973 • 145 citations

Self antigens and epitope spreading in systemic autoimmunity

1997 • 140 citations

Human Ro ribonucleoprotein particles: characterization of native structure and stable association with the La polypeptide.

1990 • 121 citations

Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.

1993 • 111 citations

Self-peptides in the initiation of lupus autoimmunity.

1995 • 111 citations

ANTI-Ro IN SJÖGREN’S SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS

1992 • 88 citations

The immune response to 52-kDa Ro and 60-kDa Ro is linked in experimental autoimmunity.

1996 • 77 citations

A Model of Peptide-Induced Lupus Autoimmune B Cell Epitope Spreading Is Strain Specific and Is Not H-2 Restricted in Mice

1998 • 76 citations

Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro autoantigen results in anti-Ro ribonucleoprotein autoimmunity.

1996 • 71 citations

The 52‐kd protein as a target of intermolecular spreading of the immune response to components of the SS‐A/Ro‐SS‐B/La complex

1997 • 70 citations

Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins.

1994 • 70 citations

Ro RNP associated Y RNAs are highly conserved among mammals

1993 • 62 citations

Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice.

1996 • 61 citations

Rapid induction of autoantibodies by endogenous ovarian antigens and activated T cells: implication in autoimmune disease pathogenesis and B cell tolerance.

1996 • 42 citations

Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro

1996 • 33 citations

Autoimmune ovarian disease: mechanism of disease induction and prevention

1997 • 28 citations