Persistence of Physiological Self Antigen Is Required for the Regulation of Self Tolerance

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

1996 • 770 citations

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

1985 • 721 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

Photolysis of the Carbon Monoxide Complex of Myoglobin: Nanosecond Time-Resolved Crystallography

1996 • 573 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus

1996 • 449 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis

1989 • 346 citations

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.

1982 • 321 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

T cell priming versus T cell tolerance induced by synthetic peptides.

1995 • 230 citations

Maintenance of in Vivo Tolerance by Persistence of Antigen

1992 • 209 citations

Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida.

1992 • 190 citations

Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.

1993 • 184 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

THYMIC DEPENDENCE OF LOSS OF TOLERANCE IN MIXED ALLOGENEIC BONE MARROW CHIMERAS AFTER DEPLETION OF DONOR ANTIGEN

1996 • 179 citations

Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance.

1987 • 166 citations

Studies on Tolerance of the Y Chromosome Antigen in Mice

1960 • 161 citations

Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein.

1989 • 152 citations

Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity.

1996 • 149 citations

Tolerance mechanism in experimental ovarian and gastric autoimmune diseases.

1992 • 134 citations

Sex steroids and the rheumatic diseases

1985 • 133 citations

Tolerance in Transgenic Mice Expressing Major Histocompatibility Molecules Extrathymically on Pancreatic Cells

1990 • 117 citations

EVIDENCE THAT THE CONTINUED PRESENCE OF THE ORGAN GRAFT AND NOT PERIPHERAL DONOR MICROCHIMERISM IS ESSENTIAL FOR MAINTENANCE OF TOLERANCE TO ALLOANTIGEN IN VIVO IN ANTI-CD4 TREATED RECIPIENTS1,2

1996 • 113 citations

Estrogen Deficiency Accelerates Autoimmune Exocrinopathy in Murine Sjögren's Syndrome through Fas-Mediated Apoptosis

1999 • 109 citations

Oocyte-specific gene expression: molecular characterization of a cDNA coding for ZP-3, the sperm receptor of the mouse zona pellucida.

1986 • 103 citations

Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy.

1991 • 96 citations

An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice.

1990 • 90 citations

Sex steroids and the immune system—I. Sex difference in autoimmune disease in NZB/NZW hybrid mice

1980 • 89 citations

On the Mechanism of Immunologic Self Recognition

1962 • 89 citations

Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens.

1994 • 78 citations

Macrophage NO2− production as a sensitive and rapid assay for the quantitation of murine IFN-γ

1991 • 74 citations

T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.

1992 • 65 citations

Alloantigen persistence in induction and maintenance of transplantation tolerance.

1987 • 62 citations

T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells.

1988 • 59 citations

Function of the MHC.

1988 • 58 citations

Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance

1995 • 54 citations

Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction.

1995 • 51 citations

Autoimmune Ovarian Inflammation Triggered by Proinflammatory (Th1) T Cells Is Compatible with Normal Ovarian Function in Mice1

1999 • 47 citations

Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.

1979 • 46 citations

Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen.

1995 • 44 citations

Neonatal Injection of an Ovarian Peptide Induces Autoimmune Ovarian Disease in Female Mice: Requirement of Endogenous Neonatal Ovaries

1997 • 42 citations

Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein

1993 • 40 citations

Resistance to experimental autoimmune encephalomyelitis induced by neonatal tolerization to myelin basic protein: clonal elimination vs. regulation of autoaggressive lymphocytes

1989 • 39 citations

Interception of the development of self tolerance in fetal lambs

1989 • 32 citations

Autoimmune ovarian disease: mechanism of disease induction and prevention

1997 • 28 citations

Acquisition of immunological self-recognition by the fetal rat.

1988 • 20 citations

Induction of long-term H-Y-specific tolerance in female mice given male lymphoid cells while transiently depleted of CD4+ or CD8+ T cells.

1993 • 18 citations

Tolerance induction during ontogeny

1983 • 9 citations

Induction of neonatal transplantation tolerance and lymphoproliferative disorders in mice: the role of F1 donor cells.

1995 • 3 citations