5 The origins of genomic imprinting in mammals

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

The DNA methyltransferases of mammals

2000 • 1,981 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

Role for DNA methylation in genomic imprinting

1994 • 1,695 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

2000 • 1,545 citations

Completion of mouse embryogenesis requires both the maternal and paternal genomes

1984 • 1,529 citations

A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

1991 • 1,469 citations

The DNA sequence of human chromosome 21

2000 • 1,406 citations

Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis

1984 • 1,402 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

Genomic imprinting in mammalian development: a parental tug-of-war

1991 • 1,178 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

DNA methylation and the frequency of CpG in animal DNA

1980 • 1,146 citations

Active demethylation of the paternal genome in the mouse zygote

2000 • 964 citations

Interspersed repeats and other mementos of transposable elements in mammalian genomes

1999 • 959 citations

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a

2000 • 943 citations

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

2000 • 866 citations

Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation

1998 • 820 citations

Tsix, a gene antisense to Xist at the X-inactivation centre

1999 • 809 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

1997 • 753 citations

Size Control in Animal Development

1999 • 742 citations

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

1997 • 705 citations

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

2001 • 687 citations

X-chromosome inactivation: counting, choice and initiation

2001 • 678 citations

DNA methylation and chromatin modification

1999 • 641 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

GENOMIC IMPRINTING IN MAMMALS

1997 • 641 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

1994 • 597 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest

1998 • 571 citations

Transposable elements as sources of variation in animals and plants

1997 • 569 citations

A Shift from Reversible to Irreversible X Inactivation Is Triggered during ES Cell Differentiation

2000 • 552 citations

A Critical Role for Murine Complement Regulator Crry in Fetomaternal Tolerance

2000 • 528 citations

Regulation of Maternal Behavior and Offspring Growth by Paternally Expressed Peg3

1999 • 504 citations

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

1997 • 496 citations

The Sins of the Fathers and Mothers

1999 • 489 citations

A role for the Ras signalling pathway in synaptic transmission and long-term memory

1997 • 474 citations

Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene

1994 • 471 citations

DIFFERENTIAL IMPRINTING AND EXPRESSION OF MATERNAL AND PATERNAL GENOMES

1988 • 451 citations

CpG islands and genes

1995 • 449 citations

Neomorphic agouti mutations in obese yellow mice

1994 • 437 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference

2000 • 412 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith–Wiedemann syndrome

1999 • 405 citations

Allele-specific replication timing of imprinted gene regions

1993 • 385 citations

Genomic imprinting of Mash2, a mouse gene required for trophoblast development

1995 • 366 citations

Imprinting and the Initiation of Gene Silencing in the Germ Line

1998 • 359 citations

Review: Chromatin Structural Features and Targets That Regulate Transcription

2000 • 348 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

Intergenic transcription and transinduction of the human β-globin locus

1997 • 334 citations

The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

2000 • 304 citations

Methylation and Imprinting: from Host Defense to Gene Regulation?

1993 • 299 citations

A mouse model for Prader-Willi syndrome imprinting-centre mutations

1998 • 298 citations

Role of mother-young interactions in the survival of offspring in domestic mammals

2000 • 289 citations

Genomic imprinting of p57KIP2, a cyclin–dependent kinase inhibitor, in mouse

1995 • 288 citations

The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1

2000 • 280 citations

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1992 • 279 citations

Phenotypic alterations in insulin-deficient mutant mice

1997 • 272 citations

Disruption of Imprinted X Inactivation by Parent-of-Origin Effects at Tsix

2000 • 271 citations

Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage.

1994 • 270 citations

M6P/IGF2R Imprinting Evolution in Mammals

2000 • 266 citations

X Inactivation in the Mouse Embryo Deficient for Dnmt1: Distinct Effect of Hypomethylation on Imprinted and Random X Inactivation

2000 • 265 citations

The imprinted gene and parent-of-origin effect database

2001 • 256 citations

Ancient origin of the Hox gene cluster

2001 • 255 citations

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2

1997 • 248 citations

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster

1998 • 245 citations

A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2

1999 • 244 citations

Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.

1997 • 243 citations

The insulin–like growth factor type–2 receptor gene is imprinted in the mouse but not in humans

1993 • 238 citations

Homologous Association of Oppositely Imprinted Chromosomal Domains

1996 • 238 citations

Functional Polymorphism in the Parental Imprinting of the Human IGF2R Gene

1993 • 228 citations

A Novel Imprinted Gene, Encoding a RING Zinc-Finger Protein, and Overlapping Antisense Transcript in the Prader-Willi Syndrome Critical Region

1999 • 225 citations

CpG islands as genomic footprints of promoters that are associated with replication origins

1999 • 225 citations

Promoter-specific imprinting of the human insulin-like growth factor-II gene

1994 • 222 citations

Delta-like and Gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12

2000 • 220 citations

Disruption of the mouse necdin gene results in early post-natal lethality

1999 • 207 citations

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19

2000 • 203 citations

Mechanisms of genomic imprinting

1999 • 203 citations

Animal Parthenogenesis

1977 • 202 citations

Allele specificity of DNA replication timing in the Angelman/Prader–Willi syndrome imprinted chromosomal region

1994 • 195 citations

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern

1997 • 195 citations

Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS–M

1996 • 195 citations

Sustained Long Term Potentiation and Anxiety in Mice Lacking theMas Protooncogene

1998 • 192 citations

Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos

2000 • 191 citations

Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis

1998 • 187 citations

Mobile elements and the human genome

2000 • 186 citations

The Human Magel2 Gene and Its Mouse Homologue Are Paternally Expressed and Mapped to the Prader-Willi Region

1999 • 183 citations

Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in Beckwith-Wiedemann syndrome

2000 • 178 citations

Allelic expression of IGF2 in marsupials and birds

2000 • 177 citations

N-myc mRNA Forms an RNA-RNA Duplex with Endogenous Antisense Transcripts

1990 • 173 citations

Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms.

1995 • 165 citations

An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus

2000 • 160 citations

MAMMALS THAT BREAK THE RULES: Genetics of Marsupials and Monotremes

1996 • 160 citations

Paternal Deletion from Snrpn to Ube3a in the Mouse Causes Hypotonia, Growth Retardation and Partial Lethality and Provides Evidence for a Gene Contributing to Prader-Willi Syndrome

1999 • 159 citations

Genomic imprinting — defusing the ovarian time bomb

1994 • 156 citations

Oppositely imprinted genes p57Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome

1999 • 156 citations

Paternal versus maternal transmission of a stimulatory G-protein α subunit knockout produces opposite effects on energy metabolism

2000 • 153 citations

Demethylation of CpG islands in embryonic cells

1991 • 151 citations

De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switch

2000 • 149 citations

Birthweight and Perinatal Mortality: II. On Weight-Specific Mortality

1983 • 148 citations

Genomic imprinting in mammals: an interplay between chromatin and DNA methylation?

1999 • 147 citations

Developmental potential of mouse primordial germ cells

1999 • 147 citations

Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting

2000 • 140 citations

Production of Androgenetic Zebrafish (Danio rerio)

1996 • 139 citations

Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice

2001 • 130 citations

Small Evolutionarily Conserved RNA, Resembling C/D Box Small Nucleolar RNA, Is Transcribed from PWCR1, a Novel Imprinted Gene in the Prader-Willi Deletion Region, Which Is Highly Expressed in Brain

2000 • 128 citations

Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse

2000 • 128 citations

The imprinting box of the mouse Igf2r gene

1999 • 121 citations

The imprinting box of the Prader-Willi/Angelman syndrome domain

2000 • 119 citations

Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain

1998 • 119 citations

Conservation of a maternal-specific methylation signal at the human IGF2R locus

1995 • 116 citations

Competition- a common motif for the imprinting mechanism?

1997 • 115 citations

Sequence and Comparative Analysis of the Mouse 1-Megabase Region Orthologous to the Human 11p15 Imprinted Domain

2000 • 113 citations

Retrovirus-induced insertional mutation in Mov13 mice affects collagen I expression in a tissue-specific manner

1989 • 111 citations

DNA Methylation de Novo

1999 • 109 citations

An Imprinted Mouse Transcript Homologous to the Human Imprinted in Prader-Willi Syndrome (IPW) Gene

1997 • 105 citations

A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting

1999 • 103 citations

Igf2 imprinting does not require its own DNA methylation or H19 RNA

1998 • 101 citations

The structural H19 gene is required for transgene imprinting

1996 • 95 citations

Enhancer competition between H19 and Igf 2 does not mediate their imprinting

1999 • 93 citations

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus

1996 • 93 citations

Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation

1999 • 90 citations

Characterization of a methylation imprint in the Prader — Willi syndrome chromosome region

1993 • 89 citations

DNA Demethylation Reactivates a Subset of Imprinted Genes in Uniparental Mouse Embryonic Fibroblasts

2001 • 88 citations

Natural selection and the function of genome imprinting: beyond the silenced minority

2000 • 86 citations

Do we understand the evolution of genomic imprinting?

1998 • 86 citations

Factors affecting the timing and imprinting of replication on a mammalian chromosome

1995 • 83 citations

The uniqueness of the imprinting mechanism

2000 • 83 citations

Human insulin-like growth factor type I and type II receptors are not imprinted

1993 • 78 citations

Chromatin conformation of the H19 epigenetic mark

1998 • 76 citations

Comparative Genome Analysis of the Mouse Imprinted GeneImpactand Its Nonimprinted Human HomologIMPACT:Toward the Structural Basis for Species-Specific Imprinting

2000 • 75 citations

Gtl2 lacZ , an insertional mutation on mouse Chromosome 12 with parental origin-dependent phenotype

1996 • 71 citations

Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo

1997 • 70 citations

Allele-specific replication timing in imprinted domains: absence of asynchrony at several loci

1995 • 68 citations

Genomic Imprinting in Plants

1999 • 65 citations

Imprinting and Paternal Genome Elimination in Insects

1999 • 64 citations

Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14.

1995 • 62 citations

Tissue-Specific Imprinting of the Mouse Insulin-Like Growth Factor II Receptor Gene Correlates with Differential Allele-Specific DNA Methylation

1998 • 57 citations

Mit1/Lb9andCopg2, new members of mouse imprinted genes closely linked toPeg1/Mest

2000 • 56 citations

Allele-specific gene expression in mammals: the curious case of the imprinted RNAs.

1994 • 56 citations

Role of a 461-bp G-rich repetitive element in H19 transgene imprinting

1999 • 51 citations

Polymorphic Functional Imprinting of the Human IGF2 Gene among Individuals, in Blood Cells, Is Associated with H19 Expression

1996 • 51 citations

A Direct Repeat Sequence at theRasgrf1Locus and Imprinted Expression

1999 • 50 citations

The Dynamic genome: Barbara McClintock's ideas in the century of genetics

1993 • 50 citations

Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts

1998 • 48 citations

Organization and Parent-of-Origin-Specific Methylation of Imprinted Peg3 Gene on Mouse Proximal Chromosome 7

2000 • 48 citations

Expression of the rat BFGF antisense RNA transcript is tissue-specific and developmentally regulated

1996 • 47 citations

Characterization of the C3 YAC Contig from Proximal Mouse Chromosome 17 and Analysis of Allelic Expression of Genes Flanking the Imprinted Igf2r Gene

1997 • 46 citations

A Methylation Imprint Mark in the Mouse Imprinted GeneGrf1/Cdc25MmLocus Shares a Common Feature with theU2afbp-rsGene: An Association with a Short Tandem Repeat and a Hypermethylated Region

1998 • 40 citations

Conserved characteristics of heterochromatin-forming DNA at the 15q11-q13 imprinting center

1999 • 38 citations

Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in HL60 cells

2000 • 34 citations

Parental imprinting of an IGF‐2 transgene

1993 • 34 citations

GROWTH AND ITS CONTROL IN EARLY MAMMALIAN DEVELOPMENT

1981 • 30 citations

Analysis of murine Snrpn and human SNRPN gene imprinting in transgenic mice

1999 • 30 citations

The Oocyte-Specific Methylated Region of the U2afbp-rs/U2af1-rs1 Gene Is Dispensable for Its Imprinted Methylation

2000 • 27 citations

Polymorphic and tissue-specific imprinting of the human wilms tumor gene,WT1

1997 • 26 citations

An Oocyte-Specific Methylation Imprint Center in the MouseU2afbp-rs/U2af1-rs1Gene Marks the Establishment of Allele-Specific Methylation during Preimplantation Development

1997 • 24 citations

Adult Parthenogenetic Chickens

1973 • 24 citations

A Human p57KIP2 Transgene Is Not Activated by Passage Through the Maternal Mouse Germline

1999 • 23 citations

Mothers Setting Boundaries

2000 • 22 citations

Sense and antisense transcripts of the developmentally regulated murine hsp70.2 gene are expressed in distinct and only partially overlapping areas in the adult brain

1996 • 22 citations

Review Article: Genomic imprinting: concept and clinical consequences

1999 • 18 citations

Maternal and paternal genomes function independently in mouse ova in establishing expression of the imprinted genes Snrpn and Igf2r: no evidence for allelic trans-sensing and counting mechanisms.

1996 • 16 citations

Nucleotide Sequence of a 28-kb Mouse Genomic Region Comprising the Imprinted Igf2 Gene

1996 • 16 citations

Parthenogenetic lizards as vertebrate systems

1990 • 8 citations

Differential chromatin packaging of genomic imprinted regions between expressed and non-expressed alleles

2000 • 6 citations

A HUNTING WASP

1878 • 5 citations

Allelic trans-sensing and Imprinting

1999 • 4 citations

Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta

1999 • 3 citations