A Human p57KIP2 Transgene Is Not Activated by Passage Through the Maternal Mouse Germline

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Going the Distance: A Current View of Enhancer Action

1998 • 820 citations

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

1997 • 753 citations

Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15

1995 • 606 citations

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

1997 • 496 citations

Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells

1997 • 469 citations

Influence of PAX6 Gene Dosage on Development: Overexpression Causes Severe Eye Abnormalities

1996 • 435 citations

Uniparental paternal disomy in a genetic cancer-predisposing syndrome

1991 • 432 citations

Disruption of insulin–like growth factor 2 imprinting in Beckwith–Wiedemann syndrome

1993 • 427 citations

An imprinted gene p57KIP2 is mutated in Beckwith–Wiedemann syndrome

1996 • 390 citations

Loss of imprinting of a paternally expressed transcript, with antisense orientation to K _V LQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

1999 • 360 citations

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements

1997 • 354 citations

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

1997 • 349 citations

Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome

1997 • 325 citations

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.

1996 • 302 citations

Genomic imprinting of p57KIP2, a cyclin–dependent kinase inhibitor, in mouse

1995 • 288 citations

Imprinting-Mutation Mechanisms in Prader-Willi Syndrome

1999 • 276 citations

Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells.

1996 • 256 citations

Multiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster

1998 • 245 citations

Abnormality of chromosome 11 in patients withfeatures of Beckwith-Wiedemann syndrome

1983 • 236 citations

Epigenotype switching of imprintable loci in embryonic germ cells

1998 • 205 citations

Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis

1998 • 187 citations

DNA methylation: A molecular lock

1997 • 179 citations

The vagaries of variegating transgenes

1996 • 165 citations

Trisomy 11p15 and Beckwith-Wiedemann syndrome. A report of two cases

1984 • 156 citations

Developmental potential of mouse primordial germ cells

1999 • 147 citations

Low Frequency of p57KIP2 Mutation in Beckwith-Wiedemann Syndrome

1997 • 141 citations

Coding Mutations in p57 Are Present in Some Cases of Beckwith-Wiedemann Syndrome but Are Rare or Absent in Wilms Tumors

1997 • 140 citations

Genomic imprinting of human p57KIP2 and its reduced expression in Wilms' tumors

1996 • 139 citations

Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith- Wiedemann syndrome

1997 • 126 citations

Location of enhancers is essential for the imprinting of H19 and Igf2 genes

1998 • 126 citations

Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors

1996 • 115 citations

Syntenic Organization of the Mouse Distal Chromosome 7 Imprinting Cluster and the Beckwith-Wiedemann Syndrome Region in Chromosome 11p15.5

1998 • 109 citations

Imprinting of Igf2 and H19 from a 130 kb YAC transgene

1997 • 108 citations

Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments.

1995 • 108 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.

1994 • 108 citations

Selective maternal-allele loss in human lung cancers of the maternally expressed p57(KIP2) gene at 11p15.5

1996 • 104 citations

Disproportionate growth in mice with Igf-2 transgenes.

1994 • 102 citations

Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype

1996 • 100 citations

A 2.5-Mb Transcript Map of a Tumor-Suppressing Subchromosomal Transferable Fragment from 11p15.5, and Isolation and Sequence Analysis of Three Novel Genes

1997 • 89 citations

Complementation of null CF mice with a human CFTR YAC transgene

1997 • 77 citations

Two Novel Genes in the Center of the 11p15 Imprinted Domain Escape Genomic Imprinting

1999 • 74 citations

Characterization of the human p57KIP2 gene: Alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis

1996 • 70 citations

A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues

1996 • 59 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth

1994 • 55 citations

Imprinting of the mouse Igf2r gene depends on an intronic CpG island

1998 • 44 citations

LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs

1998 • 39 citations

Parental imprinting of an IGF‐2 transgene

1993 • 34 citations

An infant with Beckwith-Wiedemann syndrome and chromosomal duplication 11p13→pter.: Correlation of symptoms between 11p trisomy and Beckwith-Wiedemann syndrome

1986 • 33 citations

The X‐linked immunodeficiency defect in the mouse is corrected by expression of human Bruton's tyrosine kinase from a yeast artificial chromosome transgene

1997 • 30 citations

Mechanism of imprinting on mouse distal chromosome 7

1998 • 16 citations

Selective maternal-allele loss in human lung cancers of the maternally expressed p57[KIP2] gene at 11p15.5

1998 • 4 citations