Competition- a common motif for the imprinting mechanism?

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

UBE3A/E6-AP mutations cause Angelman syndrome

1997 • 1,270 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

1991 • 904 citations

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

1997 • 847 citations

Disruption of imprinting caused by deletion of the H19 gene region in mice

1995 • 765 citations

Xist-deficient mice are defective in dosage compensation but not spermatogenesis.

1997 • 705 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4

1996 • 572 citations

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

1994 • 519 citations

Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons

1997 • 495 citations

Gametic Imprinting in Mammals

1995 • 444 citations

Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region

1994 • 430 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

A paternal–specific methylation imprint marks the alleles of the mouse H19 gene

1995 • 410 citations

Allele-specific replication timing of imprinted gene regions

1993 • 385 citations

DNA hypomethylation can activate Xist expression and silence X-linked genes.

1996 • 377 citations

DNA methylation and imprinting: why bother?

1997 • 370 citations

Human KVLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements

1997 • 354 citations

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1995 • 351 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Creation of genomic methylation patterns

1996 • 313 citations

DNA methylation in early development

1995 • 283 citations

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1992 • 279 citations

Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes

1994 • 277 citations

Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene

1996 • 257 citations

Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element.

1997 • 243 citations

Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome

1997 • 237 citations

Promoter-specific imprinting of the human insulin-like growth factor-II gene

1994 • 222 citations

Allele specificity of DNA replication timing in the Angelman/Prader–Willi syndrome imprinted chromosomal region

1994 • 195 citations

Minimal definition of the imprinting center and fixation of chromosome 15q11-q13 epigenotype by imprinting mutations.

1996 • 176 citations

PARENTAL IMPRINTING AND HUMAN DISEASE

1996 • 170 citations

Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms.

1995 • 165 citations

An Imprinted Mouse Transcript Homologous to the Human Imprinted in Prader-Willi Syndrome (IPW) Gene

1997 • 105 citations

The structural H19 gene is required for transgene imprinting

1996 • 95 citations

Imprinted genes and regulation of gene expression by epigenetic inheritance

1996 • 88 citations

Factors affecting the timing and imprinting of replication on a mammalian chromosome

1995 • 83 citations

Cytosine methylation The pros and cons of DNA methylation

1993 • 83 citations

Epigenetic regulation of gene expression: the effect of altered chromatin structure from yeast to mammals

1995 • 82 citations

A 5′ Differentially Methylated Sequence and the 3′-Flanking Region Are Necessary for H19 Transgene Imprinting

1997 • 77 citations

Activators and repressors: making use of chromatin to regulate transcription

1997 • 75 citations

Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor

1997 • 70 citations

Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo

1997 • 70 citations

Multiple roles for DNA methylation in gametic imprinting

1996 • 66 citations

Genetic imprinting in the mouse: Implications for gene regulation

1994 • 58 citations

Allele-specific gene expression in mammals: the curious case of the imprinted RNAs.

1994 • 56 citations

Genomic Imprinting in Mice: Its Function and Mechanism1

1996 • 54 citations

Signal transduction and regulation of translation initiation

1992 • 50 citations

Parental imprinting of an IGF‐2 transgene

1993 • 34 citations

UBE3A/E6-AP mutations cause Angelman syndrome

1996 • 28 citations

Parental Imprinting on Mouse Chromosome 7

1996 • 26 citations

Identification of a novel paternally expressed transcript adjacent to snRPN in the Prader-Willi syndrome critical region.

1996 • 26 citations

Gametic imprinting in development and disease

1997 • 24 citations

Imprints on islands

1993 • 20 citations

Ends Xist, but where are the beginnings?

1997 • 10 citations