GATA-3 - not just for Th2 cells anymore.

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

2006 • 1,535 citations

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

2001 • 1,505 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

2003 • 1,187 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes

2005 • 1,013 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

1989 • 931 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

2006 • 776 citations

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

1997 • 723 citations

Regulation of B Lymphocyte and Macrophage Development by Graded Expression of PU.1

2000 • 712 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells

2004 • 689 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland

2006 • 648 citations

DNA-Binding Specificity of GATA Family Transcription Factors

1993 • 629 citations

Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

2004 • 625 citations

REGULATION OF TH2 DIFFERENTIATION ANDIl4LOCUS ACCESSIBILITY

2006 • 625 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

DNA-Binding Specificities of the GATA Transcription Factor Family

1993 • 553 citations

SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes

2006 • 528 citations

T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3

2005 • 505 citations

GATA transcription factors: key regulators of hematopoiesis.

1995 • 430 citations

Long-range intrachromosomal interactions in the T helper type 2 cytokine locus

2004 • 421 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression

2000 • 383 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

1998 • 357 citations

Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG

1998 • 352 citations

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

2004 • 339 citations

GATA-3: an unexpected regulator of cell lineage determination in skin

2003 • 334 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily.

1992 • 332 citations

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

1991 • 316 citations

T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics

2006 • 315 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

2003 • 272 citations

Signaling pathways in Th2 development

2004 • 258 citations

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

2005 • 256 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

Treatment of Allergic Airway Inflammation and Hyperresponsiveness by Antisense-Induced Local Blockade of Gata-3 Expression

2001 • 239 citations

Regulation of IL-4 Gene Expression by Distal Regulatory Elements and GATA-3 at the Chromatin Level

2001 • 234 citations

Embryonic expression and cloning of the murine GATA-3 gene

1994 • 233 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells

2003 • 226 citations

Regulation of the Th2 Cytokine Locus by a Locus Control Region

2003 • 222 citations

CD83 Expression Influences CD4+ T Cell Development in the Thymus

2002 • 213 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Gene Silencing Quantitatively Controls the Function of a Developmental trans-Activator

2002 • 204 citations

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

1999 • 201 citations

Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus

2002 • 194 citations

Critical functions for c-Myb at three checkpoints during thymocyte development

2004 • 184 citations

Mutation of Tec family kinases alters T helper cell differentiation

2001 • 174 citations

GATA-3 Significantly Downregulates IFN-γ Production from Developing Th1 Cells in Addition to Inducing IL-4 and IL-5 Levels

1999 • 172 citations

Signaling through Itk Promotes T Helper 2 Differentiation via Negative Regulation of T-bet

2004 • 164 citations

Ras-ERK MAPK Cascade Regulates GATA3 Stability and Th2 Differentiation through Ubiquitin-Proteasome Pathway

2005 • 163 citations

Characterization of GATA3 Mutations in the Hypoparathyroidism, Deafness, and Renal Dysplasia (HDR) Syndrome

2004 • 162 citations

Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci

2004 • 160 citations

TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression

2000 • 158 citations

GATA3 abnormalities and the phenotypic spectrum of HDR syndrome

2001 • 157 citations

PU.1 Expression Delineates Heterogeneity in Primary Th2 Cells

2005 • 154 citations

c-Myb is essential for early T cell development

1999 • 153 citations

The Cell Type-Specific Expression of the Murine IL-13 Gene Is Regulated by GATA-3

2001 • 152 citations

Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus.

1996 • 145 citations

ROG, Repressor of GATA, Regulates the Expression of Cytokine Genes

2000 • 139 citations

GATA-3 Directly Remodels the IL-10 Locus Independently of IL-4 in CD4+ T Cells

2006 • 139 citations

Cyclic AMP Activates p38 Mitogen-Activated Protein Kinase in Th2 Cells: Phosphorylation of GATA-3 and Stimulation of Th2 Cytokine Gene Expression

2000 • 138 citations

Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements

1995 • 137 citations

GATA-3 Regulates the Development and Function of Invariant NKT Cells

2006 • 125 citations

PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer.

1994 • 123 citations

Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs

2000 • 119 citations

Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes

2000 • 113 citations

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

2004 • 109 citations

Expression of GATA‐3 During Lymphocyte Differentiation and Mouse Embryogenesis

1992 • 105 citations

The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.

1991 • 105 citations

Embryonic expression of the human GATA-3 gene

1999 • 98 citations

Physical and Functional Interaction between GATA-3 and Smad3 Allows TGF-β Regulation of GATA Target Genes

2002 • 98 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice

2001 • 97 citations

The GATA-3 gene is expressed during human kidney embryogenesis

1995 • 95 citations

GATA-3 in Human T Cell Helper Type 2 Development

2004 • 94 citations

Key Residues Characteristic of GATA N-fingers Are Recognized By FOG

1998 • 93 citations

Enforced Expression of GATA-3 in Transgenic Mice Inhibits Th1 Differentiation and Induces the Formation of a T1/ST2-Expressing Th2-Committed T Cell Compartment In Vivo

2001 • 92 citations

Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes

2006 • 90 citations

Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells

2001 • 86 citations

Definition of Regulatory Network Elements for T Cell Development by Perturbation Analysis with PU.1 and GATA-3

2002 • 84 citations

Structure and Specificity of GATA Proteins in Th2 Development

2001 • 81 citations

CD8 T Cell-Specific Downregulation of Histone Hyperacetylation and Gene Activation of the IL-4 Gene Locus by ROG, Repressor of GATA

2003 • 80 citations

Acetylation of GATA-1 is required for chromatin occupancy

2006 • 80 citations

Requirement ofc-mybin T cell development and in mature T cell function

2004 • 79 citations

HD mice: A novel mouse mutant with a specific defect in the generation of CD4⁺T cells

1998 • 75 citations

Interleukin-13 Gene Expression Is Regulated by GATA-3 in T Cells

2002 • 75 citations

Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development

2002 • 69 citations

GATA3 is downregulated during hair cell differentiation in the mouse cochlea.

1998 • 65 citations

GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter

2003 • 65 citations

Knock-in Mutation of Transcription Factor GATA-3 into the GATA-1 Locus: Partial Rescue of GATA-1 Loss of Function in Erythroid Cells

1998 • 63 citations

Protein Kinase A-Dependent Synergism between GATA Factors and the Nuclear Receptor, Liver Receptor Homolog-1, Regulates Human Aromatase (CYP19) PII Promoter Activity in Breast Cancer Cells

2005 • 62 citations

Regulation of Th2 Cytokine Expression in NKT Cells: Unconventional Use of Stat6, GATA-3, and NFAT2

2006 • 61 citations

Unraveling a Revealing Paradox

2003 • 56 citations

Functional GATA-3 binding sites within murine CD8 alpha upstream regulatory sequences.

1993 • 56 citations

Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP

2000 • 55 citations

Regulation of Th2 Cell Development by Polycomb Group Gene bmi-1 through the Stabilization of GATA3

2006 • 53 citations

Friend of GATA Is Expressed in Naive Th Cells and Functions As a Repressor of GATA-3-Mediated Th2 Cell Development

2002 • 53 citations

The Interaction between GATA Proteins and Activator Protein-1 Promotes the Transcription ofIL-13in Mast Cells

2004 • 52 citations

Enforced Expression of GATA-3 Severely Reduces Human Thymic Cellularity

2001 • 41 citations

GATA-3 Dominant Negative Mutant

1995 • 39 citations

CD4/CD8 lineage commitment: light at the end of the tunnel?

2006 • 33 citations

Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment

2005 • 33 citations

ROG Negatively Regulates T-Cell Activation but Is Dispensable for Th-Cell Differentiation

2005 • 31 citations

Chewing the fat on natural killer T cell development

2006 • 30 citations

Critical YxKxHxxxRP Motif in the C-Terminal Region of GATA3 for Its DNA Binding and Function

2006 • 28 citations

Evidence of GATA-3-dependent Th2 commitment during the in vivo immune response

2003 • 27 citations

Involvement of GATA-3-dependent Th2 lymphocyte activation in airway hyperresponsiveness

2006 • 23 citations

A conserved sequence block in the murine and human T cell receptor Jalpha loci interacts with developmentally regulated nucleoprotein complexes in vitro and associates with GATA-3 and octamer-binding factors in vivo.

2001 • 14 citations

Th2 Immune Responses in GATA-3-Transgenic Mice Infected with <i>Heligmosomoides polygyrus</i>

2003 • 12 citations