The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

2002 • 1,749 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

2004 • 625 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

2005 • 401 citations

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes

2004 • 381 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

Cullin-based ubiquitin ligases: Cul3–BTB complexes join the family

2004 • 375 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

All in the Family: the BTB/POZ, KRAB, and SCAN Domains

2001 • 338 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Crystal structure of the BTB domain from PLZF

1998 • 301 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Mechanism of SMRT Corepressor Recruitment by the BCL6 BTB Domain

2003 • 283 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

TOX: an HMG box protein implicated in the regulation of thymocyte selection

2002 • 176 citations

CCR7 Directs the Migration of Thymocytes into the Thymic Medulla

2004 • 173 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

1999 • 130 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo

2004 • 111 citations

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

2004 • 109 citations

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

2002 • 106 citations

Role of CD8β Domains in CD8 Coreceptor Function

2000 • 105 citations

APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity

1998 • 101 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

CD4⧸CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis of the CD4⧸CD8 Lineage Decision

2004 • 95 citations

c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.

1994 • 94 citations

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

1994 • 77 citations

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

1993 • 71 citations

Regulation of human COL2A1 gene expression in chondrocytes: identification of C-KROX responsive elements and modulation by phenotype alteration

2000 • 71 citations

c-Krox Binds to Several Sites in the Promoter of Both Mouse Type I Collagen Genes

1996 • 67 citations

Regulation of Human COL2A1 Gene Expression in Chondrocytes

2000 • 66 citations

Unraveling a Revealing Paradox

2003 • 56 citations

Restricting Zap70 Expression to CD4+CD8+ Thymocytes Reveals a T Cell Receptor–dependent Proofreading Mechanism Controlling the Completion of Positive Selection

2003 • 47 citations

Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection.

1995 • 44 citations

The CD4⧸CD8 Lineage Choice: New Insights into Epigenetic Regulation during T Cell Development

2004 • 41 citations