Definition of Regulatory Network Elements for T Cell Development by Perturbation Analysis with PU.1 and GATA-3

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

Regulation of B Lymphocyte and Macrophage Development by Graded Expression of PU.1

2000 • 712 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

1999 • 457 citations

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

1999 • 444 citations

GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts.

1995 • 430 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

2000 • 351 citations

GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription

2000 • 333 citations

PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors

2002 • 316 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

PU.1 Functions in a Cell-Autonomous Manner to Control the Differentiation of Multipotential Lymphoid–Myeloid Progenitors

1997 • 276 citations

Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development.

1994 • 275 citations

Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage

1999 • 259 citations

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression

2000 • 210 citations

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1999 • 208 citations

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

1999 • 201 citations

CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells

1996 • 200 citations

A Role for Pref-1 and HES-1 in Thymocyte Development

2000 • 196 citations

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

2001 • 195 citations

Early stages in the development of human T, natural killer and thymic dendritic cells

1998 • 192 citations

Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

2001 • 190 citations

Constitutive Expression of PU.1 in Fetal Hematopoietic Progenitors Blocks T Cell Development at the Pro-T Cell Stage

2002 • 169 citations

Commitment of Common T/Natural Killer (Nk) Progenitors to Unipotent T and Nk Progenitors in the Murine Fetal Thymus Revealed by a Single Progenitor Assay

1999 • 169 citations

c-Myb is essential for early T cell development

1999 • 153 citations

Impairment of T Cell Development in δ EF1 Mutant Mice

1997 • 139 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

Branching out to gain control: how the pre-TCR is linked to multiple functions

2000 • 124 citations

The linkage between T‐cell and dendritic cell development in the mouse thymus

1998 • 118 citations

Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR

1999 • 110 citations

T Cell Development in PU.1-Deficient Mice

1999 • 102 citations

Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus

2000 • 92 citations

Expression and Function of a Stem Cell Promoter for the Murine CBFα2 Gene: Distinct Roles and Regulation in Natural Killer and T Cell Development

2001 • 91 citations

The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development

1999 • 88 citations

Presence of progenitors restricted to T, B, or myeloid lineage, but absence of multipotent stem cells, in the murine fetal thymus.

1998 • 84 citations

Stepwise specification of lymphocyte developmental lineages

2000 • 81 citations

T-cell Expression of the Human GATA-3 Gene Is Regulated by a Non-lineage-specific Silencer

1999 • 77 citations

Cutting Edge: Presence of Progenitors Restricted to T, B, or Myeloid Lineage, but Absence of Multipotent Stem Cells, in the Murine Fetal Thymus

1998 • 71 citations

Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis

2001 • 68 citations

Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines

2000 • 53 citations

T cell fate specification and αβ/γδ lineage commitment

2001 • 51 citations

Transcriptional regulation of lymphocyte lineage commitment

1999 • 48 citations

Enforced Expression of GATA-3 Severely Reduces Human Thymic Cellularity

2001 • 41 citations

Elements of Transcription Factor Network Design for T-Lineage Specification

2002 • 41 citations

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

2000 • 34 citations

Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment

1998 • 26 citations

Cloning Thymic Precursor Cells: Demonstration That Individual Pro-T1 Cells Have Dual T–NK Potential and Individual Pro-T2 Cells Have Dual αβ–γδ T Cell Potential

1999 • 12 citations