Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

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1998 • 1,184 citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

1995 • 1,130 citations

Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome

1997 • 1,066 citations

DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1

2001 • 1,062 citations

A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

2001 • 1,022 citations

Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice

2001 • 996 citations

TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome

2001 • 963 citations

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

1997 • 909 citations

Retinoids in Embryonal Development

2000 • 859 citations

Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.

1993 • 708 citations

Xwnt11is a target ofXenopusBrachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway

2000 • 677 citations

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

2001 • 675 citations

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

1997 • 660 citations

Eomesodermin is required for mouse trophoblast development and mesoderm formation

2000 • 610 citations

Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

2001 • 586 citations

NK-2Homeobox Genes and Heart Development

1996 • 574 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

1999 • 552 citations

Chamber-Specific Cardiac Expression of Tbx5 and Heart Defects in Holt–Oram Syndrome

1999 • 501 citations

Chamber Formation and Morphogenesis in the Developing Mammalian Heart

2000 • 483 citations

Cardiomyocyte Cell Cycle Regulation

2002 • 452 citations

Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6

1998 • 408 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 406 citations

Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse

2001 • 400 citations

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation

2002 • 353 citations

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

2000 • 350 citations

NKX2.5 Mutations in Patients With Tetralogy of Fallot

2001 • 333 citations

Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes

1998 • 333 citations

Crystallographic structure of the T domain–DNA complex of the Brachyury transcription factor

1997 • 327 citations

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1992 • 323 citations

Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.

1997 • 323 citations

Control of Cardiac Development by an Evolutionarily Conserved Transcriptional Network

2002 • 315 citations

Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-β and bone morphogenetic protein (BMP)

2000 • 310 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 308 citations

The T-box gene family

1998 • 307 citations

Early Signals in Cardiac Development

2002 • 297 citations

Role of Pitx1 Upstream of Tbx4 in Specification of Hindlimb Identity

1999 • 294 citations

Identification of Novel DNA Binding Targets and Regulatory Domains of a Murine Tinman Homeodomain Factor, nkx-2.5

1995 • 289 citations

The T protein encoded by Brachyury is a tissue-specific transcription factor.

1995 • 287 citations

Development of the Cardiac Conduction System

1998 • 282 citations

Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development

2002 • 281 citations

Recruitment of the Tinman Homolog Nkx-2.5 by Serum Response Factor Activates Cardiac α-Actin Gene Transcription

1996 • 277 citations

The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression

1998 • 274 citations

CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway

1997 • 273 citations

Evidence of a role for T-☐ genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity

1996 • 271 citations

The anterior heart-forming field: voyage to the arterial pole of the heart

2002 • 271 citations

Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFβ growth factors

1999 • 265 citations

Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds

1999 • 264 citations

GATA transcription factors and cardiac development

1999 • 259 citations

Ensembl 2002: accommodating comparative genomics

2003 • 246 citations

Cardiac homeobox gene NKX2-5mutations and congenital heart disease

2003 • 244 citations

T-box genes: what they do and how they do it

1999 • 241 citations

Cloning and expression analysis of the mouse T-box gene Tbx18

2001 • 237 citations

Tbx5 and the Retinotectum Projection

2000 • 234 citations

Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue

1992 • 228 citations

Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm

1998 • 224 citations

Maternal VegT is the initiator of a molecular network specifying endoderm in Xenopus laevis

2001 • 223 citations

Tbx5 is essential for heart development

1999 • 219 citations

Expression Pattern of Connexin Gene Products at the Early Developmental Stages of the Mouse Cardiovascular System

1997 • 219 citations

A Novel Cardiac-Restricted Target for Doxorubicin

1997 • 216 citations

T-box genes in human disorders

2003 • 204 citations

The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation

1996 • 203 citations

Myocardialization of the Cardiac Outflow Tract

1999 • 201 citations

Ventricular Expression of tbx5 Inhibits Normal Heart Chamber Development

2000 • 196 citations

Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice

1998 • 188 citations

Heart development inDrosophila and vertebrates: Conservation of molecular mechanisms

1998 • 185 citations

Brachyury-Related Transcription Factor Tbx2 and Repression of the Melanocyte-Specific TRP-1 Promoter

1998 • 171 citations

Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease

2000 • 164 citations

Formation of the Atrioventricular Septal Structures in the Normal Mouse

1998 • 159 citations

Cardiac and Extracardiac Expression of Csx/Nkx2.5 Homeodomain Protein

1998 • 157 citations

Tbx genes and limb identity in chick embryo development

1998 • 155 citations

Protein and RNA Export from the Nucleus

2002 • 154 citations

The Atrial Natriuretic Factor Promoter Is a Downstream Target for Nkx-2.5 in the Myocardium

1996 • 152 citations

Determinants of T box protein specificity

2001 • 148 citations

Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome

2001 • 147 citations

The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element

1998 • 141 citations

Fate map of early avian cardiac progenitor cells

2001 • 133 citations

TBX5 Transcription Factor Regulates Cell Proliferation during Cardiogenesis

2001 • 124 citations

Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome

1999 • 121 citations

Tinman Function Is Essential for Vertebrate Heart Development: Elimination of Cardiac Differentiation by Dominant Inhibitory Mutants of thetinman-Related Genes,XNkx2-3andXNkx2-5

1998 • 120 citations

Serum Response Factor-GATA Ternary Complex Required for Nuclear Signaling by a G-Protein-Coupled Receptor

2001 • 119 citations

Context-dependent Transcriptional Cooperation Mediated by Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4

1999 • 119 citations

MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION

1999 • 118 citations

Structure of the DNA-Bound T-Box Domain of Human TBX3, a Transcription Factor Responsible for Ulnar-Mammary Syndrome

2002 • 115 citations

Cloning and expression analysis of the mouse T-box gene Tbx20

2001 • 115 citations

Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins

2000 • 102 citations

Characterization of Homo- and Heterodimerization of Cardiac Csx/Nkx2.5 Homeoprotein

2001 • 97 citations

Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells

2002 • 96 citations

Identification and localization of TBX5 transcription factor during human cardiac morphogenesis

2000 • 95 citations

hrTis required for cardiovascular development in zebrafish

2002 • 90 citations

The Small Muscle-Specific Protein Csl Modifies Cell Shape and Promotes Myocyte Fusion in an Insulin-like Growth Factor 1–Dependent Manner

2001 • 90 citations

Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2

2000 • 87 citations

A Conserved Role for H15-Related T-Box Transcription Factors in Zebrafish and Drosophila Heart Formation

2000 • 80 citations

Murine Tbx2 contains domains that activate and repress gene transcription

2002 • 72 citations

Molecular determinants of atrial and ventricular septal defects and patent ductus arteriosus

2000 • 67 citations

Molecular determinants of atrial and ventricular septal defects and patent ductus arteriosus

2000 • 60 citations

VegT Activation of Sox17 at the Midblastula Transition Alters the Response to Nodal Signals in the Vegetal Endoderm Domain

2001 • 56 citations

Ulnar-mammary syndrome.

1987 • 52 citations

Characterization of the Human TBX20 Gene, a New Member of the T-Box Gene Family Closely Related to the Drosophila H15 Gene

2000 • 47 citations

Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development

2000 • 46 citations

Developmental paradigms in heart disease: insights from tinman

2002 • 43 citations

Developmental expression of the Xenopus laevis Tbx20 orthologue

2003 • 39 citations

Transcriptional Control and Pattern Formation in the Developing Vertebrate Heart

1999 • 38 citations

Developmental paradigms in heart disease: insights from tinman

2002 • 18 citations

Homeobox genes and heart development.

1997 • 14 citations

Molecular Determinants of Cardiac Development and Congenital Disease

2002 • 14 citations