Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Selective Events in T Cell Development

1994 • 486 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

2002 • 342 citations

Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling

2004 • 306 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

2002 • 216 citations

γ-Secretase inhibitors repress thymocyte development

2001 • 187 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

TOX: an HMG box protein implicated in the regulation of thymocyte selection

2002 • 176 citations

The Transcriptional Repressor Gfi1 Affects Development of Early, Uncommitted c-Kit+ T Cell Progenitors and CD4/CD8 Lineage Decision in the Thymus

2003 • 160 citations

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

2002 • 154 citations

Presenilin-dependent γ-secretase activity modulates thymocyte development

2001 • 153 citations

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

2002 • 149 citations

The CD8 Population in CD4-deficient Mice Is Heavily Contaminated with MHC Class II–restricted T Cells

2004 • 133 citations

Signal strength in thymic selection and lineage commitment

2001 • 132 citations

Notch signaling in T- and B-cell development

2004 • 119 citations

Regulation of RAG‐1 and CD69 expression in the thymus during positive and negative selection

1994 • 112 citations

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo

2004 • 111 citations

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

2004 • 109 citations

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1995 • 104 citations

A Reassessment of the Effect of Activated Notch1 on CD4 and CD8 T Cell Development

2002 • 102 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice

2001 • 97 citations

c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.

1994 • 94 citations

Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio

2003 • 82 citations

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals

2004 • 81 citations

HD mice: A novel mouse mutant with a specific defect in the generation of CD4⁺T cells

1998 • 75 citations

Notch signaling in lymphocyte development and function

2004 • 71 citations

TOX Provides a Link Between Calcineurin Activation and CD8 Lineage Commitment

2004 • 66 citations

The Absence of Itk Inhibits Positive Selection Without Changing Lineage Commitment

2002 • 63 citations

Activated Notch2 Potentiates CD8 Lineage Maturation and Promotes the Selective Development of B1 B Cells

2003 • 63 citations

The Regulated Expression of a Diverse Set of Genes during Thymocyte Positive Selection In Vivo

2004 • 60 citations

Strength of Signaling by CD4 and CD8 Coreceptor Tails Determines the Number but Not the Lineage Direction of Positively Selected Thymocytes

2001 • 57 citations

Unraveling a Revealing Paradox

2003 • 56 citations

Growth Factor Independence-1B Expression Leads to Defects in T Cell Activation, IL-7 Receptor α Expression, and T Cell Lineage Commitment

2003 • 56 citations

Functional Characterization of MHC Class II-Restricted CD8+CD4− and CD8−CD4− T Cell Responses to Infection in CD4−/− Mice

2004 • 48 citations

Restricting Zap70 Expression to CD4+CD8+ Thymocytes Reveals a T Cell Receptor–dependent Proofreading Mechanism Controlling the Completion of Positive Selection

2003 • 47 citations

Transgenic Expression of Numb Inhibits Notch Signaling in Immature Thymocytes But Does Not Alter T Cell Fate Specification

2002 • 46 citations

Ikaros Null Mice Display Defects in T Cell Selection and CD4 versus CD8 Lineage Decisions

2004 • 43 citations

Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice

2004 • 43 citations

The influence of the thymic environment on the CD4-versus-CD8 T lineage decision

2003 • 36 citations

Dynamic Repositioning of CD4 and CD8 Genes during T Cell Development

2004 • 33 citations

Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes

2002 • 33 citations

Detailed analysis of gene expression during development of T cell lineages in the thymus

2004 • 17 citations

The role of CD8 alpha' in the CD4 versus CD8 lineage choice.

1999 • 16 citations

The Role of CD8α′ in the CD4 Versus CD8 Lineage Choice

1999 • 13 citations