CD4/CD8 lineage commitment: light at the end of the tunnel?

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

The Role of Erk1 and Erk2 in Multiple Stages of T Cell Development

2005 • 319 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

2005 • 256 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

2002 • 244 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

The Chromatin Remodeler Mi-2β Is Required for CD4 Expression and T Cell Development

2004 • 239 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Critical Residues within the BTB Domain of PLZF and Bcl-6 Modulate Interaction with Corepressors

2002 • 208 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Suppressor of Cytokine Signaling-1 Is a Critical Regulator of Interleukin-7-Dependent CD8+ T Cell Differentiation

2003 • 169 citations

Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

2005 • 160 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Sequential Roles of Brg, the ATPase Subunit of BAF Chromatin Remodeling Complexes, in Thymocyte Development

2003 • 155 citations

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

2000 • 143 citations

The Ras/MAPK cascade and the control of positive selection

2003 • 142 citations

Csk controls antigen receptor-mediated development and selection of T-lineage cells

1998 • 138 citations

An Alternate Pathway for CD4 T Cell Development: Thymocyte-Expressed MHC Class II Selects a Distinct T Cell Population

2005 • 119 citations

Runx3 Regulates Integrin αE/CD103 and CD4 Expression during Development of CD4−/CD8+ T Cells

2005 • 112 citations

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo

2004 • 111 citations

Thymocyte-Thymocyte Interaction for Efficient Positive Selection and Maturation of CD4 T Cells

2005 • 110 citations

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells

1998 • 107 citations

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

2002 • 106 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice

2001 • 97 citations

c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.

1994 • 94 citations

Activation of the Extracellular Signal-Related Kinase/Mitogen-Activated Protein Kinase Pathway Discriminates CD4 Versus CD8 Lineage Commitment in the Thymus

1999 • 86 citations

Overexpression of the Runx3 Transcription Factor Increases the Proportion of Mature Thymocytes of the CD8 Single-Positive Lineage

2005 • 81 citations

HD mice: A novel mouse mutant with a specific defect in the generation of CD4⁺T cells

1998 • 75 citations

c-Krox Binds to Several Sites in the Promoter of Both Mouse Type I Collagen Genes

1996 • 67 citations

Modulation of Coreceptor Transcription during Positive Selection Dictates Lineage Fate Independently of TCR/Coreceptor Specificity

2005 • 64 citations

The establishment and maintenance of lymphocyte identity through gene silencing

2003 • 60 citations

Strength of Signaling by CD4 and CD8 Coreceptor Tails Determines the Number but Not the Lineage Direction of Positively Selected Thymocytes

2001 • 57 citations

Commitment to the CD4 Lineage Mediated by Extracellular Signal-Related Kinase Mitogen-Activated Protein Kinase and Lck Signaling

1999 • 49 citations

Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice

2004 • 43 citations

Visualization of CD4/CD8 T Cell Commitment

1998 • 41 citations

Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells

2005 • 39 citations

Functional and Molecular Analysis of the Double-Positive Stage-Specific CD8 Enhancer E8III during Thymocyte Development

2005 • 35 citations

Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment

2005 • 33 citations

Dynamic Repositioning of CD4 and CD8 Genes during T Cell Development

2004 • 33 citations

Analyzing Expression of Perforin, Runx3, and Thpok Genes during Positive Selection Reveals Activation of CD8-Differentiation Programs by MHC II-Signaled Thymocytes

2005 • 29 citations

An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4

2005 • 22 citations