GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

2002 • 1,108 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses

1996 • 728 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION

1999 • 293 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

2001 • 276 citations

Studies on T cell maturation on defined thymic stromal cell populations in vitro.

1992 • 249 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Transcription

2002 • 241 citations

Embryonic expression and cloning of the murine GATA-3 gene

1994 • 233 citations

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

1999 • 201 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

TOX: an HMG box protein implicated in the regulation of thymocyte selection

2002 • 176 citations

Constitutive Expression of PU.1 in Fetal Hematopoietic Progenitors Blocks T Cell Development at the Pro-T Cell Stage

2002 • 169 citations

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

2002 • 154 citations

An Invitation to T and More

2002 • 148 citations

Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus.

1996 • 145 citations

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

2000 • 143 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

ROG, Repressor of GATA, Regulates the Expression of Cytokine Genes

2000 • 139 citations

Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47

1999 • 125 citations

Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs

2000 • 119 citations

Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice

2001 • 97 citations

Thymocyte Development in Early Growth Response Gene 1-Deficient Mice

2002 • 95 citations

Definition of Regulatory Network Elements for T Cell Development by Perturbation Analysis with PU.1 and GATA-3

2002 • 84 citations

Cutting Edge: The Differential Involvement of the N-Finger of GATA-3 in Chromatin Remodeling and Transactivation During Th2 Development

2002 • 69 citations

Overexpression of AML1 Transcription Factor Drives Thymocytes into the CD8 Single-Positive Lineage

2001 • 60 citations

Peptide-Induced Positive Selection of TCR Transgenic Thymocytes in a Coreceptor-Independent Manner

1997 • 45 citations

Differential induction of helper and killer T cells from isolated CD4⁺CD8⁺ thymocytes in suspension culture

1996 • 45 citations

Enforced Expression of GATA-3 Severely Reduces Human Thymic Cellularity

2001 • 41 citations

GATA-3 Dominant Negative Mutant

1995 • 39 citations

Molecular requirements for lineage commitment in the thymus – antibody‐mediated receptor engagements reveal a central role for lck in lineage decisions

1998 • 31 citations

A Notch so simple influence on T cell development

2003 • 19 citations