Structure–Function Analysis of the ADAM Family of Disintegrin-Like and Metalloproteinase-Containing Proteins (Review)

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

Hemorrhagic metalloproteinases from snake venoms

1994 • 618 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 • 604 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.

1995 • 507 citations

Fertilization Defects in Sperm from Mice Lacking Fertilin β

1998 • 497 citations

A metalloprotease-disintegrin participating in myoblast fusion

1995 • 492 citations

Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene

1997 • 480 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

1998 • 376 citations

Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion.

1987 • 368 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

A Novel, Secreted Form of Human ADAM 12 (Meltrin α) Provokes Myogenesis in Vivo

1998 • 315 citations

[21] Snake venom metalloendopeptidases: Reprolysins

1995 • 278 citations

ADAMs in Fertilization and Development

1996 • 259 citations

Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.

1994 • 241 citations

A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion

1997 • 235 citations

ADAMTS-1 Protein Anchors at the Extracellular Matrix through the Thrombospondin Type I Motifs and Its Spacing Region

1998 • 225 citations

Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence.

1990 • 219 citations

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.

1993 • 215 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.

1996 • 213 citations

Identification and Characterization of a Pro-tumor Necrosis Factor-α-processing Enzyme from the ADAM Family of Zinc Metalloproteases

1997 • 204 citations

Human ADAM 12 (Meltrin α) Is an Active Metalloprotease

1998 • 188 citations

Snake venom metalloproteinases: Structure, function and relationship to the ADAMs family of proteins

1996 • 184 citations

The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.

1993 • 182 citations

Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence

1996 • 170 citations

Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15

1998 • 167 citations

Mouse sperm-egg plasma membrane interactions: analysis of roles of egg integrins and the mouse sperm homologue of PH-30 (fertilin) β

1995 • 157 citations

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling

1997 • 155 citations

The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs

1997 • 152 citations

Preparation and Characterization of Recombinant Tissue Inhibitor of Metalloproteinase 4 (TIMP-4)

1997 • 138 citations

Purification of ADAM 10 from bovine spleen as a TNFα convertase

1997 • 133 citations

Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage

1990 • 124 citations

The Metallo-Disintegrin ADAM10 (MADM) from Bovine Kidney Has Type IV Collagenase Activityin Vitro

1998 • 121 citations

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

1996 • 121 citations

Activation of snake venom metalloproteinases by a cysteine switch‐like mechanism

1993 • 118 citations

Expression of a disintegrin‐like protein in cultured human vascular cells and in vivo

1997 • 115 citations

Evidence for Distinct Serine Protease Activities with a Potential Role in Processing the Sperm Protein Fertilin

1997 • 113 citations

ADAM 13: A Novel ADAM Expressed in Somitic Mesoderm and Neural Crest Cells duringXenopus laevisDevelopment

1997 • 109 citations

Cloning and Initial Characterization of Mouse Meltrin β and Analysis of the Expression of Four MetalloproteaseDisintegrins in Bone Cells

1998 • 109 citations

Computational sequence analysis of matrix metalloproteinases

1996 • 107 citations

CD156 (Human ADAM8): Expression, Primary Amino Acid Sequence, and Gene Location

1997 • 104 citations

A survey of furin substrate specificity using substrate phage display

1994 • 101 citations

Computational Sequence Analysis of the Tissue Inhibitor of Metalloproteinase Family

1997 • 98 citations

A novel metalloprotease/disintegrin–like gene at 17q21.3 is somatically rearranged in two primary breast cancers

1993 • 97 citations

A family of cellular proteins related to snake venom disintegrins.

1994 • 96 citations

A mammalian epididymal protein with remarkable sequence similarity to snake venom haemorrhagic peptides

1992 • 96 citations

The human fertilin α gene is non-functional: implications for its proposed role in fertilization

1997 • 89 citations

Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain

1998 • 88 citations

Evolution of Disintegrin Cysteine-Rich and Mammalian Matrix-Degrading Metalloproteinases: Gene Duplication and Divergence of a Common Ancestor Rather Than Convergent Evolution

1996 • 86 citations

Biochemical and Molecular Characterization of Bovine Fertilin α and β (ADAM 1 and ADAM 2): A Candidate Sperm-Egg Binding/Fusion Complex1

1997 • 84 citations

The Metzincin-Superfamily of Zinc-Peptidases

1996 • 79 citations

ADAM7, A Member of the ADAM (A Disintegrin And Metalloprotease) Gene Family Is Specifically Expressed in the Mouse Anterior Pituitary and Epididymis¹

1997 • 71 citations

Identification of Metalloprotease/Disintegrins inXenopus laevisTestis with a Potential Role in Fertilization

1997 • 69 citations

The Exon/Intron Organization and Chromosomal Mapping of the Mouse ADAMTS-1 Gene Encoding an ADAM Family Protein with TSP Motifs

1997 • 68 citations

Cloning and analysis of monkey fertilin reveals novel α subunit isoforms

1995 • 64 citations

ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-α

1998 • 62 citations

Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing

1995 • 59 citations

Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides

1997 • 54 citations

Sequence analysis of a variety of primate fertilin α genes: Evidence for non-functional genes in the gorilla and man

1998 • 53 citations

Examination of the Immunocontraceptive Potential of Recombinant Rabbit Fertilin Subunits in Rabbit

1997 • 51 citations

The role of cell adhesion molecules and proteases in tumor invasion and metastasis

1996 • 46 citations

ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans.

1996 • 44 citations

Cloning and sequence analysis of rat fertilin alpha and beta-- developmental expression, processing and immunolocalization

1997 • 44 citations

The gene for the human tMDC I sperm surface protein is non-functional: implications for its proposed role in mammalian sperm–egg recognition

1998 • 44 citations

Initial evaluation of fertilin as an immunocontraceptive antigen and molecular cloning of the cynomolgus monkey fertilin β subunit

1996 • 42 citations

[23] Membrane-associated metalloproteinase recognized by characteristic cleavage of myelin basic protein: Assay and isolation

1995 • 41 citations

Cloning and expression of recombinant rabbit fertilin

1996 • 38 citations

Human fertilin β: Identification, characterization, and chromosomal mapping of an ADAM gene family member

1997 • 38 citations

Rat MDC family of proteins: Sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis

1997 • 37 citations

Analysis of transcripts encoding novel members of the mammalian metalloprotease-like, disintegrin-like, cysteine-rich (MDC) protein family and their expression in reproductive and non-reproductive monkey tissues

1995 • 34 citations

Human fertilin β: Identification, characterization, and chromosomal mapping of an ADAM gene family member

1997 • 33 citations

Sequence and expression of a monkey testicular transcript encoding tMDC I, a novel member of the metalloproteinase-like, disintegrin-like, cysteine-rich (MDC) protein family

1994 • 32 citations

Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract

1998 • 31 citations

Evidence that peptides derived from the disintegrin domain of primate fertilin and containing the ECD motif block the binding of human spermatozoa to the zona‐free hamster oocyte

1997 • 28 citations

Genetic evidence for an additional member of the metalloproteinase-like, disintegrin-like, cysteine-rich (MDC) family of mammalian proteins and its abundant expression in the testis

1994 • 25 citations

Chromosomal Assignment of Three Novel Mouse Genes Expressed in Testicular Cells

1994 • 24 citations

Radiation Hybrid Mapping of Human ADAM10 Gene to Chromosome 15

1997 • 24 citations

Molecular Cloning, Chromosomal Localization, and Expression Analysis ofCYRN1andCYRN2, Two Human Genes Coding for Cyritestin, a Sperm Protein Involved in Gamete Interaction

1998 • 20 citations

Mapping, Sequence, and Expression Analysis of the Human Fertilin β Gene (FTNB)

1997 • 12 citations

Chromosomal Assignment of Two ADAM Genes, TACE (ADAM17) and MLTNB (ADAM19), to Human Chromosomes 2 and 5, Respectively, and ofMltnbto Mouse Chromosome 11

1998 • 9 citations

Characterisation of two highly conserved but non-allelic cellular disintegrins from rabbit testis

1998 • 2 citations