Apoptotic Pathways

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

Apoptotic Pathways

1998 • 1,193 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases

1999 • 957 citations

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

2000 • 728 citations

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

2000 • 501 citations

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

2000 • 448 citations

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

1998 • 372 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

2000 • 321 citations

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release

2000 • 280 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death

2000 • 236 citations

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1999 • 157 citations

Events in Apoptosis

1996 • 109 citations

Bcl-xL does not inhibit the function of Apaf-1

2000 • 84 citations

Cell death: Drosophila Apaf-1 — no longer in the (d)Ark

2000 • 12 citations