A splicing-dependent regulatory mechanism that detects translation signals.

Exon Recognition in Vertebrate Splicing

1995 • 1,067 citations

Molecular Biology of the Cell

1990 • 951 citations

Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm

1992 • 825 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

A survey on intron and exon lengths

1988 • 569 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

Protein Translocation Across Membranes

1988 • 482 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences

1979 • 326 citations

A Regulatory Mechanism That Detects Premature Nonsense Codons in T-cell Receptor Transcripts in Vivo Is Reversed by Protein Synthesis Inhibitors in Vitro

1995 • 317 citations

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

1993 • 307 citations

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

1995 • 278 citations

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

1993 • 265 citations

A Pre-mRNA-Binding Protein Accompanies the RNA from the Gene through the Nuclear Pores and into Polysomes

1996 • 220 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

1993 • 200 citations

A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

1992 • 198 citations

Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

1985 • 193 citations

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

1993 • 179 citations

Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.

1990 • 159 citations

Intranuclear Distribution of Poly(A) RNA Determined by Electron Microscope in Situ Hybridization

1993 • 154 citations

Maintenance of an open reading frame as an additional level of scrutiny during splice site selection

1994 • 146 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

Nonsense Mutations in the Dihydrofolate Reductase Gene Affect RNA Processing

1989 • 139 citations

Identification and Characterization of a Sequence Motif Involved in Nonsense-Mediated mRNA Decay

1995 • 135 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

Nonsense Mutations Inhibit RNA Splicing in a Cell-Free System: Recognition of Mutant Codon Is Independent of Protein Synthesis

1996 • 132 citations

The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.

1995 • 132 citations

Introns are cis Effectors of the Nonsense-Codon-Mediated Reduction in Nuclear mRNA Abundance

1994 • 131 citations

Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.

1994 • 131 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Frequent Aberrant Immunoglobulin Gene Rearrangements in Pro-B Cells Revealed by a bcl-x Transgene

1996 • 120 citations

Nonsense Codons in Human β-Globin mRNA Result in the Production of mRNA Degradation Products

1992 • 118 citations

Nonsense-mediated mRNA Decay in Yeast

1994 • 109 citations

Tandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genes.

1987 • 105 citations

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

1994 • 97 citations

Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA.

1993 • 97 citations

Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance.

1994 • 96 citations

Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport.

1995 • 88 citations

RNA blots: staining procedures and optimization of conditions

1991 • 86 citations

How the ribosome moves along the mRNA during protein synthesis.

1994 • 86 citations

Nucleolar Localization of myc Transcripts

1993 • 82 citations

Nonsense Codons Can Reduce the Abundance of Nuclear mRNA without Affecting the Abundance of Pre-mRNA or the Half-Life of Cytoplasmic mRNA

1993 • 82 citations

Determination of mRNA fate by different RNA polymerase II promoters.

1993 • 66 citations

Nucleolar localization of myc transcripts.

1993 • 60 citations

Translation to Near the Distal End of the Penultimate Exon Is Required for Normal Levels of Spliced Triosephosphate Isomerase mRNA

1990 • 55 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 54 citations

New proteins related to the Ser-Arg family of splicing factors.

1995 • 54 citations

Mutations in nucleolar proteins lead to nucleolar accumulation of polyA+ RNA in Saccharomyces cerevisiae.

1995 • 54 citations

Translation affects immunoglobulin mRNA stability

1989 • 52 citations

Nonsense but Not Missense Mutations Can Decrease the Abundance of Nuclear mRNA for the Mouse Major Urinary Protein, While Both Types of Mutations Can Facilitate Exon Skipping

1994 • 50 citations

T Cell Receptor-β mRNA Splicing: Regulation of Unusual Splicing Intermediates

1993 • 46 citations

Mammalian Nonsense Codons Can Be cis Effectors of Nuclear mRNA Half-Life

1994 • 44 citations

Induction of T-cell receptor-alpha and -beta mRNA in SL12 cells can occur by transcriptional and post-transcriptional mechanisms.

1988 • 41 citations

On the linkage between RNA processing and RNA translatability.

1994 • 38 citations

Heat shock affects 5′ splice site selection, cleavage and ligation of CAD pre-mRNA in hamster cells, but not its packaging in InRNP particles

1994 • 38 citations

Order of Intron Removal during Splicing of Endogenous Adenine Phosphoribosyltransferase and Dihydrofolate Reductase Pre-mRNA

1993 • 37 citations

Frameshift Mutations in the v-src Gene of Avian Sarcoma Virus Act in cis To Specifically Reduce v-src mRNA Levels

1994 • 36 citations

T cell receptor-beta mRNA splicing during thymic maturation in vivo and in an inducible T cell clone in vitro.

1993 • 28 citations

Frameshift mutations in the v-src gene of avian sarcoma virus act in cis to specifically reduce v-src mRNA levels.

1994 • 14 citations

Frequent aberrant immunoglobulin gene rearrangements in PRO-B cells revealed by a BCL-XL transgene

1996 • 1 citations