Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

Physical change in cytoplasmic messenger ribonucleoproteins in cells treated with inhibitors of mRNA transcription.

1984 • 334 citations

beta 0 thalassemia, a nonsense mutation in man.

1979 • 291 citations

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

1981 • 267 citations

Nonsense mutations in the human beta-globin gene affect mRNA metabolism.

1988 • 229 citations

Premature translation termination mediates triosephosphate isomerase mRNA degradation.

1988 • 229 citations

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

1987 • 206 citations

beta zero thalassemia in Sardinia is caused by a nonsense mutation.

1981 • 192 citations

RNA processing errors in patients with beta-thalassemia.

1982 • 150 citations

Nonsense Mutations in the Dihydrofolate Reductase Gene Affect RNA Processing

1989 • 139 citations

Temperature Sensitive Mutants of BHK 21 Cells

1972 • 138 citations

A temperature‐sensitive cell cycle mutant of the BHK cell line

1974 • 132 citations

Regulation of Protein Synthesis in Chick Oviduct

1973 • 131 citations

Physical Change in Cytoplasmic Messenger Ribonucleoproteins in Cells Treated with Inhibitors of mRNA Transcription

1984 • 110 citations

Stability of globin mRNA in terminally differentiating murine erythroleukemia cells

1981 • 108 citations

Inactive X chromosome DNA does not function in DNA-mediated cell transformation for the hypoxanthine phosphoribosyltransferase gene.

1980 • 106 citations

Beta O-39 thalassemia gene: a premature termination codon causes beta- mRNA deficiency without affecting cytoplasmic beta-mRNA stability

1984 • 106 citations

Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon

1984 • 102 citations

Structure and expression of a cloned β°thalassaemic globin gene

1981 • 85 citations

Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level.

1988 • 83 citations

Premature Translation Termination Mediates Triosephosphate Isomerase mRNA Degradation

1988 • 82 citations

New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo.

1988 • 74 citations

The Rapid Acceleration of Hepatic Nuclear Ribonucleic Acid Breakdown by Actinomycin But Not by Ethionine

1968 • 71 citations

Impaired nuclear transport of a human variant tRNAiMet

1982 • 64 citations

Variability in the amount of β-globin mRNA in β0 thalassemia

1978 • 63 citations

Changes in RNA polymerase II in a cell cycle‐specific temperature‐sensitive mutant of hamster cells

1980 • 54 citations

RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2.

1990 • 52 citations

Interferon action: Transcriptional control of a gene specifying a 56,000-Da protein in ehrlich ascites tumor cells

1985 • 42 citations

Studies on the efficiency of translation and on the stability of actin messenger ribonucleic acid in mouse sarcoma ascites cells

1979 • 40 citations

Both Cell Substratum Regulation and Hormonal Regulation of Milk Protein Gene Expression Are Exerted Primarily at the Posttranscriptional Level

1988 • 29 citations

Cellular factor affecting the stability of β-globin mRNA

1988 • 25 citations

Equal stabilities of normal beta globin and nontranslatable beta0 -39 thalassemic transcripts in cell-free extracts

1987 • 21 citations

RNA Processing Is a Limiting Step for Murine Tumor Necrosis Factor β Expression in Response to Interleukin-2

1990 • 13 citations

Metabolism of Non‐Translatable Globin mRNAs Arising from Premature Translation Termination Codons

1990 • 4 citations