Nonsense Codons Can Reduce the Abundance of Nuclear mRNA without Affecting the Abundance of Pre-mRNA or the Half-Life of Cytoplasmic mRNA

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

Translation is required for regulation of histone mRNA degradation

1987 • 345 citations

Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

1988 • 345 citations

The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

1991 • 297 citations

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

1981 • 267 citations

Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography

1992 • 254 citations

Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent MyoD expression in presumptive mesoderm of X. laevis

1991 • 248 citations

Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.

1991 • 239 citations

Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast.

1990 • 138 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

Effect of Protein Synthesis Inhibitors on Growth Factor Activation of c-fos, c-myc, and Actin Gene Transcription

1986 • 132 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man.

1985 • 121 citations

Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3' end of the mRNA.

1987 • 110 citations

Structure andin vitrotranscription of a human H4 histone gene

1983 • 104 citations

Expression of c-fos in NIH3T3 cells is very low but inducible throughout the cell cycle.

1986 • 97 citations

Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5′ termini.

1992 • 90 citations

Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications.

1986 • 70 citations

Sequences controlling histone H4 mRNA abundance.

1987 • 68 citations

Disruption of the cytoskeleton with cytochalasin D induces c-fos gene expression

1991 • 57 citations

Translation to Near the Distal End of the Penultimate Exon Is Required for Normal Levels of Spliced Triosephosphate Isomerase mRNA

1990 • 55 citations

Determinants that Contribute to Cytoplasmic Stability of Human c-fos and β-Globin mRNAs are Located at Several Sites in Each mRNA

1988 • 42 citations

Autoregulated Changes in Stability of Polyribosome-Bound β-Tubulin mRNAs Are Specified by the First 13 Translated Nucleotides

1988 • 40 citations

Nonsense Codons within the Rous Sarcoma Virus gag Gene Decrease the Stability of Unspliced Viral RNA

1991 • 32 citations