Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Genomic sequencing.

1984 • 8,343 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

A survey on intron and exon lengths

1988 • 569 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae.

1990 • 409 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

Exon Definition May Facilitate Splice Site Selection in RNAs with Multiple Exons

1990 • 269 citations

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

1981 • 267 citations

Nonsense mutations in the human beta-globin gene affect mRNA metabolism.

1988 • 229 citations

Premature translation termination mediates triosephosphate isomerase mRNA degradation.

1988 • 229 citations

Maximizing Gene Expression

1986 • 213 citations

In vivo splicing products of the rabbit β-globin pre-mRNA

1984 • 209 citations

Codon Replacement in the PGK1 Gene of Saccharomyces Cerevisiae: Experimental Approach to study the role of Biased Codon Usage in Gene Expression

1987 • 198 citations

Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

1985 • 193 citations

Nonsense Mutations in the Dihydrofolate Reductase Gene Affect RNA Processing

1989 • 139 citations

Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes.

1981 • 129 citations

Effect of premature termination of translation on mRNA stability depends on the site of ribosome release.

1987 • 127 citations

mRNA-deficint β^°-thaladssemia results from a single nucleotide deletion

1982 • 111 citations

Beta O-39 thalassemia gene: a premature termination codon causes beta- mRNA deficiency without affecting cytoplasmic beta-mRNA stability

1984 • 106 citations

Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon

1984 • 102 citations

Sequence-Independent Autoregulation of the Adenovirus Type 5 E1A Transcription Unit

1985 • 86 citations

Structure and expression of a cloned β°thalassaemic globin gene

1981 • 85 citations

Premature Translation Termination Mediates Triosephosphate Isomerase mRNA Degradation

1988 • 82 citations

Beta O-39 thalassemia gene: a premature termination codon causes beta- mRNA deficiency without affecting cytoplasmic beta-mRNA stability

1984 • 82 citations

The Instability of Messenger RNA in Bacteria

1986 • 75 citations

New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo.

1988 • 74 citations

Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice.

1989 • 56 citations

Transcriptional Regulatory Sequences of the Housekeeping Gene for Human Triosephosphate Isomerase

1989 • 51 citations

A β°-thalassemic β-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells

1985 • 27 citations

Delayed processing of dihydrofolate reductase heterogeneous nuclear RNA in amino acid-starved mouse fibroblasts.

1983 • 23 citations

Analysis of gene expression using episomal mouse dihydrofolate reductase minigenes

1988 • 18 citations

Delayed processing/export of messenger RNA under conditions of reduced protein synthesis

1988 • 12 citations

RNA processing mutants at the dihydrofolate reductase locus in Chinese hamster ovary cells.

1990 • 11 citations

Delayed Processing of Dihydrofolate Reductase Heterogeneous Nuclear RNA in Amino Acid-Starved Mouse Fibroblasts

1983 • 10 citations