Nonsense but Not Missense Mutations Can Decrease the Abundance of Nuclear mRNA for the Mouse Major Urinary Protein, While Both Types of Mutations Can Facilitate Exon Skipping

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

Scrambled exons

1991 • 827 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

Interference of nonsense mutations with eukaryotic messenger RNA stability.

1979 • 454 citations

The Skipping of Constitutive Exons in Vivo Induced by Nonsense Mutations

1993 • 440 citations

Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

1989 • 417 citations

THE MUTATION AND POLYMORPHISM OF THE HUMAN β-GLOBIN GENE AND ITS SURROUNDING DNA

1984 • 404 citations

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

1992 • 368 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1992 • 367 citations

Transport of Proteins Across the Endoplasmic Reticulum Membrane

1992 • 366 citations

Translation is required for regulation of histone mRNA degradation

1987 • 345 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

1993 • 307 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

1991 • 297 citations

General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.

1993 • 286 citations

Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

1985 • 193 citations

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

1993 • 179 citations

Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns.

1990 • 169 citations

Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing.

1992 • 168 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation.

1991 • 151 citations

Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene

1992 • 150 citations

A role for exon sequences in alternative splicing of the human fibronection gene

1987 • 145 citations

Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast.

1990 • 138 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Analyis of factor VIII mRNA reveals defects in everyone of 28 haemophilia A patients

1993 • 123 citations

Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo.

1988 • 115 citations

Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3' end of the mRNA.

1987 • 110 citations

Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation.

1994 • 101 citations

Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing

1989 • 101 citations

A nonsense mutation and exon skipping in the Fanconi anaemia group C gene

1993 • 91 citations

A single nucleotide polymorphism in an exon dictates allele dependent differential splicing of episialin mRNA

1991 • 85 citations

Structure of mouse major urinary protein genes: different splicing configurations in the 3′-non-coding region.

1984 • 83 citations

Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells

1992 • 82 citations

Sequences controlling histone H4 mRNA abundance.

1987 • 68 citations

mRNA Turnover in Saccharomyces cerevisiae

1993 • 52 citations

In vitro splicing of cardiac troponin T precursors. Exon mutations disrupt splicing of the upstream intron.

1992 • 51 citations

In vitro analysis of bovine growth hormone pre-mRNA alternative splicing. Involvement of exon sequences and trans-acting factor(s)

1993 • 40 citations

Mouse DNA sequences complementary to small nuclear RNA U1

1982 • 16 citations