A Regulatory Mechanism That Detects Premature Nonsense Codons in T-cell Receptor Transcripts in Vivo Is Reversed by Protein Synthesis Inhibitors in Vitro

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 • 580 citations

A survey on intron and exon lengths

1988 • 569 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

T cell antigen receptors and the immunoglobulin supergene family

1985 • 453 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences

1979 • 326 citations

The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

1985 • 283 citations

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

1995 • 279 citations

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

1995 • 278 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

1993 • 200 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

T-Cell Receptor β-Chain Expression: Dependence on Relatively Few Variable Region Genes

1985 • 197 citations

Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse.

1985 • 193 citations

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

1993 • 179 citations

Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.

1990 • 159 citations

Gene transfer and expression. A laboratory manual

1992 • 140 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

Introns are cis Effectors of the Nonsense-Codon-Mediated Reduction in Nuclear mRNA Abundance

1994 • 131 citations

Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.

1994 • 131 citations

Translation and the stability of mRNAs encoding the transferrin receptor and c-fos.

1991 • 127 citations

Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.

1992 • 124 citations

Nonsense-mediated mRNA Decay in Yeast

1994 • 109 citations

Tandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genes.

1987 • 105 citations

Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.

1994 • 97 citations

Clonal diversity and T-cell receptor beta-chain variable gene expression in enlarged lymph nodes of MRL-lpr/lpr lupus mice.

1986 • 96 citations

RNA blots: staining procedures and optimization of conditions

1991 • 86 citations

Nuclear degradation of nonsense mutated β-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of β-thalassemia?

1995 • 73 citations

Determination of mRNA fate by different RNA polymerase II promoters.

1993 • 66 citations

Rapid mRNA Degradation Mediated by the c-fos 3′ AU-Rich Element and That Mediated by the Granulocyte-Macrophage Colony-Stimulating Factor 3′ AU-Rich Element Occur through Similar Polysome-Associated Mechanisms

1995 • 57 citations

Gene transfer and expression: A laboratory manual

1991 • 54 citations

Translation affects immunoglobulin mRNA stability

1989 • 52 citations

Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene.

1990 • 51 citations

T Cell Receptor-β mRNA Splicing: Regulation of Unusual Splicing Intermediates

1993 • 46 citations

Rous sarcoma virus RNA stability requires an open reading frame in the gag gene and sequences downstream of the gag-pol junction.

1994 • 42 citations

Induction of T-cell receptor-alpha and -beta mRNA in SL12 cells can occur by transcriptional and post-transcriptional mechanisms.

1988 • 41 citations

T cell receptor beta-chain genes in BW5147 and other AKR tumors. Deletion order of murine V beta gene segments and possible 5' regulatory regions.

1988 • 40 citations

On the linkage between RNA processing and RNA translatability.

1994 • 38 citations

Frameshift Mutations in the v-src Gene of Avian Sarcoma Virus Act in cis To Specifically Reduce v-src mRNA Levels

1994 • 36 citations

Evidence for degradation of mRNA encoding alpha-L-iduronidase in Hurler fibroblasts with premature termination alleles.

1994 • 35 citations

Human immunoglobulin heavy-chain minilocus recombination in transgenic mice: gene-segment use in mu and gamma transcripts.

1993 • 34 citations

A new murine model system for the in vitro development of thymoma cell heterogeneity.

1984 • 30 citations

Transport and secretion of truncated T cell receptor beta-chain occurs in the absence of association with CD3.

1990 • 30 citations

T cell receptor-beta mRNA splicing during thymic maturation in vivo and in an inducible T cell clone in vitro.

1993 • 28 citations

Complex regulation of the T cell receptor α gene: three different modes of triggering induction

1988 • 14 citations