Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor-α and Lipopolysaccharide

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

2001 • 742 citations

Innate immunity: the missing link in neuroprotection and neurodegeneration?

2002 • 695 citations

Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means

1998 • 574 citations

ABC Transporters and the Blood-Brain Barrier

2004 • 521 citations

Molecular insights on the cerebral innate immune system

2003 • 414 citations

Localisation of breast cancer resistance protein in microvessel endothelium of human brain

2002 • 405 citations

Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines

2005 • 388 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 358 citations

Expression, Up-Regulation, and Transport Activity of the Multidrug-Resistance Protein Abcg2 at the Mouse Blood-Brain Barrier

2004 • 315 citations

Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy

2000 • 310 citations

Pregnane X Receptor Up-Regulation of P-Glycoprotein Expression and Transport Function at the Blood-Brain Barrier

2004 • 287 citations

Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood–brain barrier

1999 • 276 citations

Rat brain vascular distribution of interleukin‐1 type‐1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli

2004 • 248 citations

Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood–brain barrier

2003 • 229 citations

Innate Immunity and Inflammation: A Transcriptional Paradigm

2001 • 228 citations

Vascular biology of endothelin.

1998 • 188 citations

Rapid Regulation of P-Glycoprotein at the Blood-Brain Barrier by Endothelin-1

2004 • 162 citations

Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin

2003 • 129 citations

Trafficking of Canalicular ABC Transporters in Hepatocytes

2002 • 121 citations

P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules

1995 • 107 citations

Modulation of Drug Transporters at the Blood-Brain Barrier

2004 • 104 citations

Endothelin Peptides in Brain Diseases

1996 • 93 citations

Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of 99mTc-tetrofosmin

2000 • 82 citations

Influence of tumor necrosis factor-α on the expression and function of P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT

2003 • 54 citations

Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants—a case of molecular hijacking

2002 • 45 citations

Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport

2003 • 38 citations

Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

2002 • 30 citations

Evaluation of the role of P-glycoprotein in inflammation induced blood–brain barrier damage

2002 • 21 citations

The Brain Endothelin System as Potential Target for Brain-Related Pathologies

2002 • 19 citations