P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids

Transdermal drug delivery

2008 • 2,942 citations

The skin: an indispensable barrier

2008 • 1,671 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Barrier Function of the Skin: “La Raison d'Être” of the Epidermis

2003 • 1,076 citations

Adverse effects of topical glucocorticosteroids

2005 • 1,015 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Guidelines for treatment of atopic eczema (atopic dermatitis) Part I

2012 • 646 citations

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1999 • 457 citations

Mathematical models of skin permeability: An overview

2011 • 325 citations

Skin permeabilization for transdermal drug delivery: recent advances and future prospects

2014 • 318 citations

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

2005 • 268 citations

A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P‐glycoprotein activity in vitro

2002 • 229 citations

Expression of Multiple Cytochrome P450 Enzymes and Multidrug Resistance-Associated Transport Proteins in Human Skin Keratinocytes

2001 • 218 citations

Variable modulation of opioid brain uptake by P-glycoprotein in mice

2003 • 211 citations

Choosing topical corticosteroids.

2009 • 206 citations

Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies.

2001 • 177 citations

Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

2002 • 166 citations

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

2010 • 157 citations

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide

2004 • 150 citations

P-glycoprotein (P-gp/MDR1)-Mediated Efflux of Sex-Steroid Hormones and Modulation of P-gp Expression In Vitro

2004 • 141 citations

Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein

2002 • 137 citations

Side population cells in human and mouse epidermis lack stem cell characteristics

2004 • 137 citations

Structural Determinants of P-Glycoprotein-Mediated Transport of Glucocorticoids

2003 • 123 citations

Cytochrome P450: A Target for Drug Development for Skin Diseases

2004 • 122 citations

Blood-Brain Barrier (BBB) Pharmacoproteomics: Reconstruction of In Vivo Brain Distribution of 11 P-Glycoprotein Substrates Based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice

2011 • 119 citations

The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone

2002 • 105 citations

Optimization of topical therapy: partitioning of drugs into stratum corneum.

1990 • 101 citations

Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations

2013 • 97 citations

Biotransformation of Drugs in Human Skin

2008 • 96 citations

Levels of fluconazole in serum, stratum corneum, epidermis-dermis (without stratum corneum) and eccrine sweat

1993 • 95 citations

Expression of multidrug resistance P-glycoprotein in kidney allografts from cyclosporine A-treated patients

2001 • 92 citations

Skin cells and tissue are capable of using l-ergothioneine as an integral component of their antioxidant defense system

2009 • 91 citations

Active Influx Transport is Mediated by Members of the Organic Anion Transporting Polypeptide Family in Human Epidermal Keratinocytes

2003 • 85 citations

Different Skin Thinning Potential of Equipotent Medium-Strength Glucocorticoids

2002 • 77 citations

Thiolated chitosan: Development and in vitro evaluation of an oral delivery system for acyclovir

2007 • 66 citations

Orally administered ketoconazole: route of delivery to the human stratum corneum

1983 • 65 citations

In Vitro Predictability of Drug-Drug Interaction Likelihood of P-Glycoprotein-Mediated Efflux of Dabigatran Etexilate Based on [I]₂/IC₅₀ Threshold

2013 • 52 citations

PDZK1 Regulates Breast Cancer Resistance Protein in Small Intestine

2011 • 45 citations

Minimization of Local and Systemic Adverse Effects of Topical Glucocorticoids by Nanoencapsulation: In Vivo Safety of Hydrocortisone–Hydroxytyrosol Loaded Chitosan Nanoparticles

2015 • 43 citations

P-Glycoprotein (Abcb1) is involved in absorptive drug transport in skin

2008 • 36 citations

P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood–brain barrier

2007 • 33 citations

INTERACTION OF TRIAZOLAM AND KETOCONAZOLE IN P-GLYCOPROTEIN-DEFICIENT MICE

2004 • 32 citations

ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate

2012 • 29 citations

Multidrug Resistance—Associated Protein 1 Functions as an Efflux Pump of Xenobiotics in the Skin

2005 • 27 citations

Neonatal Murine Epidermal Cells Express a Functional Multidrug-Resistant Pump

2000 • 26 citations

H+/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport

2016 • 19 citations

Directional Transcellular Transport of Bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 Cells but not in Renal Epithelial LLC-PK1 Cells

2008 • 16 citations

Preventive Effects of Multi-Lamellar Emulsion on Low Potency Topical Steroid Induced Local Adverse Effect

2013 • 5 citations