Constructing immunoprofiles to deconstruct disease complexity in pemphigus

Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion

1991 • 1,014 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Induction of Pemphigus in Neonatal Mice by Passive Transfer of IgG from Patients with the Disease

1982 • 667 citations

Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

2008 • 531 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion

2006 • 407 citations

Atopic Dermatitis: A Disease Caused by Innate Immune Defects?

2008 • 312 citations

Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis

2004 • 305 citations

Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris.

1995 • 241 citations

A Newly Characterized HLA DQ _β Allele Associated with Pemphigus Vulgaris

1988 • 230 citations

T cell control in autoimmune bullous skin disorders

2006 • 211 citations

HLA class II allelic variation and susceptibility to pemphigus vulgaris.

1988 • 211 citations

Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris.

1997 • 170 citations

Pemphigus Vulgaris and Vegetans

1993 • 138 citations

Autoimmunity to Keratinocyte Acetylcholine Receptors in Pemphigus

2000 • 124 citations

Dichotomy of Autoreactive Th1 and Th2 Cell Responses to Desmoglein 3 in Patients with Pemphigus Vulgaris (PV) and Healthy Carriers of PV-Associated HLA Class II Alleles

2003 • 124 citations

T Cell Recognition of Desmoglein 3 Peptides in Patients with Pemphigus Vulgaris and Healthy Individuals

2004 • 117 citations

The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives

2000 • 114 citations

Pemphigus Vulgaris and Pemphigus Foliaceus Antibodies are Pathogenic in Plasminogen Activator Knockout Mice

1999 • 93 citations

Correlation of Subclasses of IgG with Disease Activity in Pemphigus vulgaris

1994 • 87 citations

Involvement of T_H1/T_H2 Cytokines in the Pathogenesis of Autoimmune Skin Disease—Pemphigus Vulgaris

2009 • 81 citations

Disease Relevant HLA Class II Alleles Isolated by Genotypic, Haplotypic, and Sequence Analysis in North American Caucasians With Pemphigus Vulgaris

2005 • 80 citations

IgG, IgA and IgE autoantibodies against the ectodomain of desmoglein 3 in active pemphigus vulgaris

2001 • 76 citations

Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3

2009 • 71 citations

Direct characterization of human T cells in pemphigus vulgaris reveals elevated autoantigen-specific Th2 activity in association with active disease

2005 • 70 citations

CD4<sup>+</sup>CD25<sup>high</sup> Regulatory T Cells Are Markedly Decreased in Blood of Patients with Pemphigus Vulgaris

2007 • 68 citations

Inhibition of the Transcription Factor Foxp3 Converts Desmoglein 3-Specific Type 1 Regulatory T Cells into Th2-Like Cells

2006 • 64 citations

E-cadherin Is an Additional Immunological Target for Pemphigus Autoantibodies

2008 • 63 citations

Immune Modulation in Pemphigus Vulgaris: Role of CD28 and IL-10

2000 • 54 citations

Analysis of the T Cells that Are Potentially Involved in Autoantibody Production in Pemphigus Vulgaris

1999 • 48 citations

Loss of the Acyl-CoA Binding Protein (Acbp) Results in Fatty Acid Metabolism Abnormalities in Mouse Hair and Skin

2006 • 46 citations

A Pilot Study of Etanercept Treatment for Pemphigus Vulgaris

2010 • 45 citations

Frequency analysis of autoreactive T‐helper 1 and 2 cells in bullous pemphigoid and pemphigus vulgaris by enzyme‐linked immunospot assay

2000 • 43 citations

Cytokine Pattern in Blister Fluid and Sera of Patients with Pemphigus

2002 • 42 citations

Successful treatment of pemphigus vulgaris with etanercept in four patients.

2009 • 37 citations

Cytokines in autoimmune bullous skin diseases. Epiphenomena or contribution to pathogenesis?

2009 • 35 citations

Pemphigus vulgaris: the other half of the story

2000 • 32 citations

The role of T cells in cutaneous autoimmune disease

2005 • 29 citations

Pemphigus Vulgaris and Its Active Disease Mouse Model

2008 • 28 citations

Significance of autoimmunity to non-desmoglein targets in pemphigus

2006 • 27 citations

CD8⁺ suppressor‐mediated regulation of human CD4⁺ T cell responses to glutamic acid decarboxylase 65

2006 • 23 citations

A new clinically relevant approach to expand myelin specific T cells

2006 • 22 citations

Pemphigus vulgaris immunoglobulin G can recognize a 130 000 MW antigen other than desmoglein 3 on peripheral blood mononuclear cell surface

2007 • 20 citations

Retracted: Desmoglein 3‐specific T regulatory 1 cells consist of two subpopulations with differential expression of the transcription factor Foxp3

2008 • 18 citations

Specific immunoglobulin isotypes correlate with disease activity, morphology, duration and HLA association in Pemphigus vulgaris

2012 • 18 citations

Analysis of intracellular cytokines using flowcytometry.

2002 • 17 citations