Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Multidrug resistance in cancer: role of ATP–dependent transporters

2002 • 5,195 citations

Regulatory T Cells: Mechanisms of Differentiation and Function

2007 • 2,574 citations

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

2009 • 1,842 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

2007 • 1,448 citations

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

2012 • 1,366 citations

Interleukin-17 and Type 17 Helper T Cells

2009 • 1,343 citations

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

2010 • 1,304 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

2011 • 1,093 citations

Fate mapping of IL-17-producing T cells in inflammatory responses

2011 • 1,086 citations

Induction and molecular signature of pathogenic TH17 cells

2012 • 1,066 citations

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

2009 • 1,038 citations

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

2009 • 1,031 citations

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

2009 • 1,009 citations

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

2009 • 981 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Glucocorticoid resistance in inflammatory diseases

2009 • 924 citations

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

2008 • 725 citations

Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor

2008 • 684 citations

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

2006 • 629 citations

Control of TH17 cells occurs in the small intestine

2011 • 615 citations

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1993 • 526 citations

Preferential recruitment of interferon‐γ–expressing T_H17 cells in multiple sclerosis

2009 • 507 citations

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

2010 • 486 citations

The physiological function of drug-transporting P-glycoproteins

1997 • 457 citations

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

2009 • 452 citations

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

2011 • 424 citations

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

2010 • 417 citations

Halofuginone Inhibits T _H 17 Cell Differentiation by Activating the Amino Acid Starvation Response

2009 • 387 citations

T_H17 Cells in Asthma and COPD

2010 • 334 citations

Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4

2010 • 291 citations

Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells

2004 • 289 citations

Human T _H 17 Cells Are Long-Lived Effector Memory Cells

2011 • 259 citations

T helper cells plasticity in inflammation

2013 • 224 citations

Detection of activity of P‐glycoprotein in human tumour samples using rhodamine 123

1992 • 172 citations

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

2009 • 169 citations

<scp>IL</scp>‐23: One cytokine in control of autoimmunity

2012 • 160 citations

Human <scp>T</scp>h17 subsets

2012 • 147 citations

TOR in the immune system

2011 • 132 citations

Minireview: Glucocorticoids in Autoimmunity: Unexpected Targets and Mechanisms

2011 • 131 citations

Immune regulation and control of regulatory T cells by OX40 and 4-1BB

2008 • 129 citations

<scp>CD</scp>161 expression characterizes a subpopulation of human regulatory <scp>T</scp> cells that produces <scp>IL</scp>‐17 in a <scp>STAT</scp>3‐dependent manner

2013 • 119 citations

Distinctive features of classic and nonclassic (<scp>T</scp>h17 derived) human <scp>T</scp>h1 cells

2012 • 117 citations

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

2003 • 112 citations

Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci

2011 • 109 citations

Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells

2011 • 95 citations

Distinct Profiles of Effector Cytokines Mark the Different Phases of Crohn’s Disease

2013 • 94 citations

Transcription Factors GATA-3 and RORγt Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma

2013 • 92 citations

Isolation and identification of two CD34⁺cell subpopulations from normal human peripheral blood

1994 • 84 citations

Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters

2013 • 60 citations

Oral and inhaled corticosteroids: Differences in P-glycoprotein (ABCB1) mediated efflux

2012 • 49 citations

CRTH2 expression on T cells in asthma

2010 • 44 citations

Impact of ATP-Binding Cassette Transporters on Human Immunodeficiency Virus Therapy

2010 • 26 citations

Expression of c-Kit and functional drug efflux are correlated in de novo acute myeloid leukaemia

1997 • 24 citations

Prolonged release and c‐kit expression of haemopoietic precursor cells mobilized by stem cell factor and granulocyte colony stimulating factor

1999 • 18 citations

Deleted Work

1955 • 0 citations