Adult Mice With Targeted Mutation of the Interleukin-11 Receptor (IL11Ra) Display Normal Hematopoiesis

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

The biology of interleukin-6

1989 • 1,964 citations

The biology of interleukin-6

1989 • 1,459 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Hematopoietic commitment during embryonic stem cell differentiation in culture.

1993 • 919 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.

1994 • 866 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

1996 • 589 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

Hematopoietic regulators: redundancy or subtlety?

1993 • 473 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

Interleukin-11: a new cytokine critical for osteoclast development.

1994 • 408 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

LIF: lots of interesting functions

1992 • 341 citations

Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal

1995 • 313 citations

Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.

1995 • 311 citations

Cytokine regulation of neuronal differentiation of hippocampal progenitor cells

1993 • 307 citations

A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy

1996 • 299 citations

Low levels of erythroid and myeloid progenitors in thrombopoietin-and c- mpl-deficient mice

1996 • 287 citations

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.

1994 • 275 citations

Subunit promiscuity among hemopoietic growth factor receptors

1991 • 273 citations

5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation.

1990 • 247 citations

Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system

1994 • 234 citations

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

1991 • 234 citations

Growth factor requirements for survival in G0 and entry into the cell cycle of primitive human hemopoietic progenitors.

1992 • 224 citations

A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

1996 • 216 citations

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.

1991 • 207 citations

Interleukin-11 enhances human megakaryocytopoiesis in vitro

1992 • 203 citations

The Steel factor

1992 • 201 citations

The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures.

1996 • 200 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 190 citations

Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.

1996 • 186 citations

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment

1994 • 184 citations

Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily

1994 • 173 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy

1994 • 161 citations

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

1991 • 156 citations

Leukemia inhibitory factor and interleukin‐11 promote maturation of murine and human megakaryocytes in vitro

1992 • 154 citations

Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells.

1991 • 151 citations

Expression and methylation of imprinted genes during in vitro differentiation of mouse parthenogenetic and androgenetic embryonic stem cell lines

1994 • 145 citations

Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets

1993 • 139 citations

Common subunits of cytokine receptors and the functional redundancy of cytokines

1992 • 131 citations

Synergistic interactions between interleukin-11 and interleukin-4 in support of proliferation of primitive hematopoietic progenitors of mice

1991 • 118 citations

Enhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11.

1992 • 115 citations

Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures

1993 • 100 citations

In vivo effects of recombinant interleukin-11 on myelopoiesis in mice

1993 • 95 citations

Interleukin-11 stimulates multiple phases of erythropoiesis in vitro

1992 • 95 citations

Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin

1994 • 93 citations

Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow

1996 • 87 citations

Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

1995 • 79 citations

Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin

1994 • 75 citations

Synergistic effects of interleukin 3 and interleukin 11 on murine megakaryopoiesis in serum-free culture.

1992 • 74 citations

Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

1995 • 73 citations

The human IL-11 receptor requires gp130 for signalling: demonstration by molecular cloning of the receptor.

1996 • 72 citations

Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras.

1993 • 65 citations

Effect of recombinant human interleukin‐11 on rat megakaryopoiesis and thrombopoiesis in vivo: comparative study with interleukin‐6

1993 • 65 citations

Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans

1992 • 63 citations

Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.

1996 • 62 citations

Interleukin-11 stimulates the proliferation of human hematopoietic CD34+ and CD34+CD33-DR- cells and synergizes with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor.

1993 • 61 citations

Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture.

1994 • 60 citations

Structural Analysis of the Gene Encoding the Murine Interleukin-11 Receptor α-Chain and a Related Locus

1996 • 58 citations

Murine interleukin-11 (IL-11) is expressed at high levels in the hippocampus and expression is developmentally regulated in the testis

1996 • 54 citations

Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans

1992 • 52 citations

Thrombopoietic Activity of Recombinant Human Interleukin 11 (rHuIL‐11) in Normal and Myelosuppressed Nonhuman Primates

1996 • 46 citations

IL-11 in combination with SLF and G-CSF or GM-CSF significantly increases expansion of isolated CD34+ cell population from cord blood vs. adult bone marrow.

1995 • 42 citations

Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11.

1994 • 40 citations

Effects of rhIL-11 on normal dogs and after sublethal radiation.

1995 • 37 citations

Accelerated cell-cycling of hematopoietic progenitor cells by growth factors

1995 • 37 citations

Etl2, A Novel Putative Type-I Cytokine Receptor Expressed during Mouse Embryogenesis at High Levels in Skin and Cells with Skeletogenic Potential

1994 • 33 citations

Identification of a Second Murine Interleukin-11 Receptor α-Chain Gene (IL11Ra2) with a Restricted Pattern of Expression

1997 • 31 citations

Prophylactic pretreatment of mice with hematopoietic growth factors induces expansion of primitive cell compartments and results in protection against 5-fluorouracil-induced toxicity

1996 • 27 citations

In vivo effects of interleukin‐11 and stem cell factor in combination with erythropoietin in the regulation of erythropoiesis

1995 • 27 citations

Interleukin-11 stimulates multilineage progenitors, but not stem cells, in murine and human long-term marrow cultures

1995 • 25 citations

Interleukin-11 expression in donor bone marrow cells improves hematological reconstitution in lethally irradiated recipient mice.

1994 • 22 citations

The combined effects of interleukin-11, stem cell factor, and granulocyte colony-stimulating factor on newborn rat hematopoiesis: significant enhancement of the absolute neutrophil count.

1994 • 22 citations

IL-11 directly stimulates murine and human erythroid burst formation in semisolid cultures.

1995 • 18 citations

Synergistic effects of stem cell factor and interleukin 6 or interleukin 11 on the expansion of murine hematopoietic progenitors in liquid suspension culture

1995 • 14 citations

Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures

1993 • 12 citations

Thrombopoiesis and thrombopoietin: the significance of "non-Tpo" cytokines [letter; comment]

1996 • 5 citations