Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development

1995 • 712 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens

1978 • 589 citations

The Hemopoietic Colony-stimulating Factors

1995 • 565 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

1991 • 512 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

1995 • 333 citations

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets

1995 • 286 citations

The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors

1995 • 283 citations

In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells

1994 • 268 citations

Megakaryocyte growth and development factor ameliorates carboplatin- induced thrombocytopenia in mice

1995 • 206 citations

Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates

1995 • 204 citations

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

1995 • 157 citations

Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.

1995 • 154 citations

Expression and methylation of imprinted genes during in vitro differentiation of mouse parthenogenetic and androgenetic embryonic stem cell lines

1994 • 145 citations

MPLV: A retrovirus complex inducing an acute myeloproliferative leukemic disorder in adult mice

1986 • 140 citations

A unique series of lymphomas related to the Ly-1+ lineage of B lymphocyte differentiation.

1984 • 124 citations

Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor

1995 • 124 citations

Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand

1995 • 114 citations

Recombinant human megakaryocyte growth and development factor (rhumgdf), a ligand for c‐mpl, produces functional human platelets in vitro

1995 • 104 citations

Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin

1995 • 93 citations

Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: measurement by specific bioassays.

1995 • 51 citations

Structure and transcription of the genomic locus encoding murine c-Mpl, a receptor for thrombopoietin.

1995 • 39 citations