C/EBP beta regulation of the tumor necrosis factor alpha gene.

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis.

1992 • 667 citations

Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

1990 • 610 citations

A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.

1991 • 604 citations

Localization of Tumor Necrosis Factor α in Synovial Tissues and at the Cartilage–Pannus Junction in Patients With Rheumatoid Arthritis

1991 • 585 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

1992 • 413 citations

Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB

1993 • 400 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

1992 • 324 citations

Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis.

1994 • 304 citations

Synovial tissue macrophage as a source of the chemotactic cytokine IL-8.

1991 • 303 citations

LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release

1990 • 300 citations

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

1992 • 299 citations

Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.

1993 • 275 citations

Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide.

1990 • 236 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction.

1992 • 218 citations

A Nuclear Factor for Interleukin-6 Expression (NF-IL6) and the Glucocorticoid Receptor Synergistically Activate Transcription of the Rat α1-Acid Glycoprotein Gene via Direct Protein-Protein Interaction

1993 • 215 citations

Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression.

1990 • 211 citations

The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.

1992 • 210 citations

Biphasic production of IL-8 in lipopolysaccharide (LPS)-stimulated human whole blood. Separation of LPS- and cytokine-stimulated components using anti-tumor necrosis factor and anti-IL-1 antibodies.

1992 • 209 citations

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.

1994 • 207 citations

In Situ Hybridization Studies of Stromelysin and Collagenase Messenger RNA Expression in Rheumatoid Synovium

1991 • 206 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells.

1993 • 195 citations

C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene.

1993 • 183 citations

The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.

1993 • 180 citations

A transcription factor which binds to the enhancers of SV40, immunoglobulin heavy chain and U2 snRNA genes

1987 • 160 citations

The Pathophysiology Of Tumor Necrosis Factors

1992 • 153 citations

Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines.

1991 • 138 citations

Regulation of the interleukin-1 beta (IL-1 beta) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL6 motifs.

1993 • 131 citations

Genetic analysis of the human tumor necrosis factor alpha/cachectin promoter region in a macrophage cell line.

1989 • 122 citations

Analysis of IL-1 and TNF-alpha gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization.

1990 • 116 citations

Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction

1993 • 112 citations

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

1991 • 86 citations

Localization of collagenase mRNA in rheumatoid arthritis synovium byin situ hybridization histochemistry

1990 • 73 citations

Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages

1992 • 72 citations

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region

1994 • 68 citations

C/EBP, NF-κB, and c-Ets Family Members and Transcriptional Regulation of the Cell-Specific and Inducible Macrophage Inflammatory Protein 1α Immediate-Early Gene

1993 • 46 citations

The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.

1992 • 45 citations

The Human Prointerleukin 1β Gene Requires DNA Sequences Both Proximal and Distal to the Transcription Start Site for Tissue-Specific Induction

1993 • 37 citations

Structure of the Chicken Myelomonocytic Growth Factor Gene and Specific Activation of Its Promoter in Avian Myelomonocytic Cells by Protein Kinases

1992 • 34 citations

Characterization of cytokine LD78 gene promoters: positive and negative transcriptional factors bind to a negative regulatory element common to LD78, interleukin-3, and granulocyte-macrophage colony-stimulating factor gene promoters.

1993 • 33 citations

Regulation of the Interleukin-1β (IL-1β) Gene by Mycobacterial Components and Lipopolysaccharide is Mediated by two Nuclear Factor-IL6 Motifs

1993 • 31 citations

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

1992 • 30 citations

Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif.

1992 • 30 citations

PMA-responsive 5' flanking sequences of the human TNF gene.

1989 • 26 citations

Structure of the chicken myelomonocytic growth factor gene and specific activation of its promoter in avian myelomonocytic cells by protein kinases.

1992 • 24 citations

Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6

1992 • 15 citations

The Core Promoter Region of the Tumor Necrosis Factor α Gene Confers Phorbol Ester Responsiveness to Upstream Transcriptional Activators

1992 • 11 citations

Characterization of Cytokine LD78 Gene Promoters: Positive and Negative Transcriptional Factors Bind to a Negative Regulatory Element Common to LD78, Interleukin-3, and Granulocyte-Macrophage Colony-Stimulating Factor Gene Promoters

1993 • 10 citations