Role of Sphingolipids in Regulating the Phospholipase D Pathway and Cell Division

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

A Regulatory Role for ARF6 in Receptor-Mediated Endocytosis

1995 • 451 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.

1984 • 410 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Lipid second messengers

1994 • 357 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

Modulation of protein kinase C and diverse cell functions by sphingosine — a pharmacologically interesting compound linking sphingolipids and signal transduction

1989 • 281 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

1996 • 251 citations

Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes.

1994 • 250 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.

1993 • 229 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Stimulation of actin stress fibre formation mediated by activation of phospholipase D

1996 • 215 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

Sphingosine 1-Phosphate Rapidly Activates the Mitogen-activated Protein Kinase Pathway by a G Protein-dependent Mechanism

1995 • 180 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.

1990 • 165 citations

cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

1994 • 165 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate

1995 • 161 citations

Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

1992 • 154 citations

Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity

1995 • 153 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Lysophosphatidic acid possesses dual action in cellproliferation.

1994 • 151 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae

1993 • 149 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Regulation of Phospholipase D in HL60 Cells

1995 • 145 citations

Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides.

1995 • 145 citations

Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate

1996 • 141 citations

Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D

1995 • 139 citations

Activation of phospholipase D by sphingoid bases in NG108-15 neural-derived cells.

1990 • 134 citations

Signal-activated phospholipases

1994 • 134 citations

Ceramide Inhibits Phospholipase D in a Cell-free System

1996 • 129 citations

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

1989 • 123 citations

Ceramide As a Modulator of Endocytosis

1995 • 121 citations

Phosphatidate phosphohydrolase and signal transduction

1996 • 119 citations

Regulation of Membrane-bound Phospholipase D by Protein Kinase C in HL60 Cells

1996 • 118 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA

1997 • 106 citations

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.

1992 • 105 citations

ADP-ribosylation Factor Functions Synergistically with a 50-kDa Cytosolic Factor in Cell-free Activation of Human Neutrophil Phospholipase D

1995 • 101 citations

Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases

1993 • 99 citations

Restoration of tRNA -primed( )-Strand DNA Synthesis to an HIV-1 Reverse Transcriptase Mutant with Extended tRNAs

1996 • 98 citations

Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism

1991 • 97 citations

ADP-ribosylation Factor Translocation Correlates with Potentiation of GTPγS-stimulated Phospholipase D Activity in Membrane Fractions of HL-60 Cells

1995 • 95 citations

The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase

1977 • 91 citations

Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine

1990 • 87 citations

Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.

1994 • 86 citations

Ceramide 1‐Phosphate Phosphatase Activity in Brain

1993 • 80 citations

Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane.

1993 • 78 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

Induction of Inducible Nitric-oxide Synthase by the Heterotrimeric G Protein Gα13*

1996 • 77 citations

Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.

1994 • 76 citations

Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

1993 • 71 citations

Purification and Characterization of a Novel Plasma Membrane Phosphatidate Phosphohydrolase from Rat Liver

1995 • 70 citations

Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes

1992 • 69 citations

Low Molecular Weight GTP-binding Proteins in HL-60 Granulocytes

1995 • 68 citations

Ceramide inhibits IgE-mediated activation of phospholipase D, but not of phospholipase C, in rat basophilic leukemia (RBL-2H3) cells.

1996 • 64 citations

Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.

1988 • 57 citations

Relationship between the displacement of phosphatidate phosphohydrolase from the membrane-associated compartment by chlorpromazine and the inhibition of the synthesis of triacylglycerol and phosphatidylcholine in rat hepatocytes

1986 • 56 citations

The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle

1996 • 55 citations

"Cross talk" between the bioactive glycerolipids and sphingolipids in signal transduction

1996 • 55 citations

Sphingosine activates cellular diacylglycerol kinase in intact Jurkat cells, a human T-cell line

1993 • 47 citations

Activation of Phospholipase D and Phosphatidylinositol 4-Phosphate 5-Kinase in HL60 Membranes Is Mediated by Endogenous Arf but Not Rho

1996 • 46 citations

The role of sphingosine in cell growth regulation and transmembrane signaling.

1993 • 44 citations

Hepatic monoacylglycerol acyltransferase is regulated by sn-1,2-diacylglycerol and by specific lipids in Triton X-100/phospholipid-mixed micelles.

1994 • 35 citations

Sphingomyelinase D: a pathogenic agent produced by bacteria and arthropods.

1993 • 30 citations

Sphingoid bases as endogenous cationic amphiphilic “drugs”

1991 • 29 citations

The effects of p21-N-ras expression in NIH-3T3 cells upon cyclic AMP metabolism

1989 • 5 citations