Skeletal Growth Factors

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Bone Resorption by Osteoclasts

2000 • 3,797 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Osteoblastic cells regulate the haematopoietic stem cell niche

2003 • 3,370 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

1999 • 2,034 citations

Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene

1991 • 2,004 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Recombinant human bone morphogenetic protein induces bone formation.

1990 • 1,538 citations

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

1994 • 1,442 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

2002 • 1,342 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1994 • 1,273 citations

Signal Transduction by the TGF-β Superfamily

2002 • 1,255 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 1,203 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Evolution of the Fgf and Fgfr gene families

2004 • 1,062 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*

1999 • 1,008 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

1996 • 959 citations

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

2001 • 943 citations

Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton

2003 • 869 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Noggin, Cartilage Morphogenesis, and Joint Formation in the Mammalian Skeleton

1998 • 810 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

The PDGF family: four gene products form five dimeric isoforms

2004 • 768 citations

Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur.

1990 • 734 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

Circulating levels of IGF-1 directly regulate bone growth and density

2002 • 689 citations

Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization

2002 • 680 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

Emerging Multipotent Aspects of Hepatocyte Growth Factor

1996 • 662 citations

Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system

1991 • 661 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 644 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

2003 • 623 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Chronic Elevation of Parathyroid Hormone in Mice Reduces Expression of Sclerostin by Osteocytes: A Novel Mechanism for Hormonal Control of Osteoblastogenesis

2005 • 616 citations

Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication*

1988 • 606 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways

2002 • 556 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.

1993 • 543 citations

PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor

2001 • 542 citations

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

1989 • 541 citations

The cell biology of transforming growth factor β

1990 • 537 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

The murine transforming growth factor-beta precursor.

1986 • 492 citations

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily

1999 • 473 citations

Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

2000 • 467 citations

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

1997 • 466 citations

Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis

2002 • 440 citations

Regulatory Effects of Insulin-Like Growth Factors I and II on Bone Collagen Synthesis in Rat Calvarial Cultures*

1989 • 436 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

2005 • 434 citations

Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

1987 • 434 citations

Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice

1999 • 430 citations

Bone morphogenetic protein-3 is a negative regulator of bone density

2001 • 420 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating Bone Differentiation

1989 • 405 citations

Insight into the physiological functions of PDGF through genetic studies in mice

2004 • 401 citations

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

1999 • 394 citations

VEGFA is necessary for chondrocyte survival during bone development

2004 • 390 citations

PDGF-D, a new protease-activated growth factor

2001 • 389 citations

Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.

1980 • 387 citations

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

1999 • 375 citations

Effects of basic fibroblast growth factor on bone formation in vitro.

1988 • 375 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.

1996 • 364 citations

Mice lackingBmp6 function

1998 • 363 citations

Targeted Overexpression of Insulin-Like Growth Factor I to Osteoblasts of Transgenic Mice: Increased Trabecular Bone Volume without Increased Osteoblast Proliferation¹

2000 • 355 citations

Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action.

1992 • 351 citations

Effects of BMP-2, BMP-4, and BMP-6 on Osteoblastic Differentiation of Bone Marrow-Derived Stromal Cell Lines, ST2 and MC3T3-G2/PA6

1996 • 348 citations

Genetics of mouse growth.

1998 • 342 citations

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

1998 • 339 citations

Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts

2000 • 338 citations

Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats.

1994 • 331 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

2005 • 321 citations

Differential Splicing in the Extracellular Region of Fibroblast Growth Factor Receptor 1 Generates Receptor Variants with Different Ligand-Binding Specificities

1992 • 321 citations

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

1988 • 314 citations

Cultured Bovine Bone Cells Synthesize Basic Fibroblast Growth Factor and Store It in Their Extracellular Matrix

1989 • 297 citations

Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures.

1988 • 297 citations

A Mouse Cerberus/Dan-Related Gene Family

1999 • 283 citations

Perspectives: Interleukin-6: An osteotropic factor?

1992 • 283 citations

Platelet-derived Growth Factor C (PDGF-C), a Novel Growth Factor That Binds to PDGF α and β Receptor

2001 • 278 citations

The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.

1996 • 274 citations

Modulation of Transforming Growth Factor-βProduction in Normal Human Osteoblast-Like Cells by 17β-Estradiol and Parathyroid Hormone

1991 • 271 citations

Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

2000 • 268 citations

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin

2000 • 265 citations

Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb

1996 • 265 citations

Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3.

1992 • 263 citations

Cell autonomous requirement for PDGFRα in populations of cranial and cardiac neural crest cells

2003 • 262 citations

Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures.

1988 • 262 citations

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

2003 • 258 citations

Insulin‐Like Growth Factor I Is Required for the Anabolic Actions of Parathyroid Hormone on Mouse Bone

2002 • 252 citations

Initiation of Osteoclast Bone Resorption by Interstitial Collagenase

1997 • 250 citations

Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells.

1992 • 247 citations

Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5

2000 • 247 citations

Insulin-like growth factor-I supports formation and activation of osteoclasts.

1992 • 245 citations

In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice

1990 • 235 citations

Multiple Bone Morphogenetic Protein 1-related Mammalian Metalloproteinases Process Pro-lysyl Oxidase at the Correct Physiological Site and Control Lysyl Oxidase Activation in Mouse Embryo Fibroblast Cultures

2001 • 234 citations

Structural and functional specificities of PDGF‐C and PDGF‐D, the novel members of the platelet‐derived growth factors family

2005 • 230 citations

Signal Transductions Induced by Bone Morphogenetic Protein-2 and Transforming Growth Factor-β in Normal Human Osteoblastic Cells

2002 • 230 citations

Bone Morphogenetic Protein 2 (BMP-2) Enhances BMP-3, BMP-4, and Bone Cell Differentiation Marker Gene Expression During the Induction of Mineralized Bone Matrix Formation in Culturesof Fetal Rat Calvarial Osteoblasts

1997 • 228 citations

BMP-2/-4 mediate programmed cell death in chicken limb buds

1996 • 228 citations

Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation

2005 • 227 citations

Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.

1996 • 224 citations

Bone morphogenetic protein receptors

1996 • 223 citations

Multiple Roles of Vascular Endothelial Growth Factor (VEGF) in Skeletal Development, Growth, and Repair

2004 • 221 citations

Effects of platelet‐derived growth factor on bone formation in vitro

1989 • 219 citations

A specific requirement for PDGF-C in palate formation and PDGFR-α signaling

2004 • 219 citations

Transforming growth factor-beta and remodeling of bone.

1991 • 216 citations

Transforming growth factor‐beta modulates the expression of osteoblast and chondroblast phenotypes in vitro

1988 • 216 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials

1994 • 214 citations

Opposite effects of bone morphogenetic protein-2 and transforming growth factor-β1 on osteoblast differentiation

2001 • 213 citations

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

1999 • 213 citations

LRP5 and Wnt Signaling: A Union Made for Bone

2004 • 207 citations

Fibroblast growth factors and their receptors

1997 • 204 citations

Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging.

1994 • 204 citations

Primary structure of human skeletal growth factor: homology with human insulin-like growth factor-II

1988 • 204 citations

Human Platelet-Derived Transforming Growth Factor-βStimulates Parameters of Bone Growth in Fetal Rat Calvariae*

1986 • 198 citations

Type β transforming growth factor (TGFβ) regulation of alkaline phosphatase expression and other phenotype‐related mRNAs in osteoblastic rat osteosarcoma cells

1987 • 196 citations

The Skeletal Structure of Insulin-Like Growth Factor I-Deficient Mice

2001 • 195 citations

Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities.

1992 • 195 citations

Transforming Growth Factor-β Stimulates Bone Matrix Apposition and Bone Cell Replication in Cultured Fetal Rat Calvariae*

1990 • 192 citations

Isolation and Characterization of Insulin-Like Growth Factor I (Somatomedin-C) from Cultures of Fetal Rat Calvariae*

1988 • 188 citations

Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins

1999 • 187 citations

Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts.

1994 • 185 citations

Effects of combining transforming growth factor beta and 1,25-dihydroxyvitamin D3 on differentiation of a human osteosarcoma (MG-63).

1992 • 185 citations

Expression of Insulin-Like Growth Factor I in Transgenic Mice with Elevated Levels of Growth Hormone Is Correlated with Growth*

1988 • 182 citations

Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

2003 • 182 citations

Skeletal Overexpression of Gremlin Impairs Bone Formation and Causes Osteopenia

2004 • 181 citations

Bone Morphogenetic Protein-2 Promotes Osteoblast Apoptosis through a Smad-independent, Protein Kinase C-dependent Signaling Pathway

2001 • 175 citations

Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women.

1993 • 171 citations

Opposing Effects of Fibroblast Growth Factor and Pertussis Toxin on Alkaline Phosphatase, Osteopontin, Osteocalcin, and Type I Collagen mRNA Levels in ROS 17/2.8 Cells

1989 • 169 citations

Growth Factors And Wound Healing: Platelet-Derived Growth Factor As A Model Cytokine

1991 • 169 citations

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

2004 • 166 citations

Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins

2004 • 164 citations

Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone.

1991 • 163 citations

Genetics, Chemistry, and Function of the IGF/IGFBP System

2000 • 163 citations

Acceleration of Fracture Healing in Nonhuman Primates by Fibroblast Growth Factor-2

2001 • 163 citations

Regulation of Growth Plate Chondrogenesis by Bone Morphogenetic Protein-2¹

2001 • 162 citations

Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture

2001 • 159 citations

Extracellular Matrix-Associated Bone Morphogenetic Proteins Are Essential for Differentiation of Murine Osteoblastic Cellsin Vitro¹

1999 • 149 citations

Effects of Fibroblast Growth Factors on Deoxyribonucleic Acid and Collagen Synthesis in Rat Parietal Bone Cells*

1989 • 148 citations

Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures.

1990 • 147 citations

Cell fate specification and competence by Coco, a maternal BMP, TGFβand Wnt inhibitor

2003 • 144 citations

Latent high molecular weight complex of transforming growth factor. beta. 1

1988 • 143 citations

Regulation of Start Site Usage in the Leader Exons of the Rat Insulin-Like Growth Factor-I Gene by Development, Fasting, and Diabetes

1991 • 141 citations

Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells.

1994 • 141 citations

Smad-Runx Interactions During Chondrocyte Maturation

2001 • 141 citations

Glucocorticoid Suppression of IGF I Transcription in Osteoblasts

2001 • 140 citations

Initial characterization of the four promoters of the human insulin-like growth factor II gene

1991 • 140 citations

Bone Morphogenetic Protein-2 Inhibits Terminal Differentiation of Myogenic Cells by Suppressing the Transcriptional Activity of MyoD and Myogenin

1997 • 139 citations

Insulin-like growth factor-I increases trabecular bone formation and osteoblastic cell proliferation in unloaded rats.

1994 • 138 citations

Estradiol Regulation of Insulin-Like Growth Factor-I Expression in Osteoblastic Cells: Evidence for Transcriptional Control

1991 • 138 citations

Fibroblast growth factor receptors have different signaling and mitogenic potentials.

1994 • 136 citations

Potential Role of Cbfa1, an Essential Transcriptional Factor for Osteoblast Differentiation, in Osteoclastogenesis: Regulation of mRNA Expression ofOsteoclast Differentiation Factor(ODF)

1998 • 135 citations

Functional Analysis of the Rat Insulin-Like Growth Factor I Gene and Identification of an IGF-I Gene Promoter

1992 • 135 citations

Fibrillin mutations in Marfan syndrome and related phenotypes

1996 • 135 citations

Platelet-Derived Growth Factor D Induces Cardiac Fibrosis and Proliferation of Vascular Smooth Muscle Cells in Heart-Specific Transgenic Mice

2005 • 134 citations

The effect of systemically administered PDGF-BB on the rodent skeleton

1996 • 133 citations

Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases.

1994 • 132 citations

Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss.

1992 • 130 citations

Biphasic Effects of Transforming Growth Factor-β on the Production of Osteoclast-Like Cells in Mouse Bone Marrow Cultures: The Role of Prostaglandins in the Generation of These Cells

1990 • 130 citations

Inhibition of basic fibroblast growth factor-induced growth promotion by overexpression of syndecan-1.

1993 • 129 citations

Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells.

1994 • 126 citations

Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E₂, growth hormone, and the insulin‐like growth factors

1994 • 126 citations

Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells.

1989 • 125 citations

Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription.

1990 • 124 citations

Bone Morphogenetic Proteins Stimulate Angiogenesis through Osteoblast-Derived Vascular Endothelial Growth Factor A

2002 • 124 citations

Recombinant Human Insulin-Like Growth Factor-Binding Protein-5 Stimulates Bone Formation Parameters in Vitro and in Vivo1

1999 • 122 citations

BMP3: To Be or Not To Be a BMP

2001 • 120 citations

Hydroxyapatite coated with hepatocyte growth factor (HGF) stimulates human osteoblasts in vitro

2000 • 120 citations

VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice

2005 • 118 citations

The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis

2000 • 114 citations

Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells.

1993 • 112 citations

Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures.

1993 • 110 citations

BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog

2001 • 110 citations

Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts¹

2000 • 107 citations

STIMULATION OF GROWTH IN THE LITTLE MOUSE

1976 • 107 citations

Parathyroid Hormone Regulates the Expression of Fibroblast Growth Factor-2 mRNA and Fibroblast Growth Factor Receptor mRNA in Osteoblastic Cells

1999 • 106 citations

Transcriptional Mechanisms of Bone Morphogenetic Protein-induced Osteoprotegrin Gene Expression

2001 • 106 citations

Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures.

1995 • 106 citations

Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line specific.

1992 • 104 citations

Platelet-Derived Growth Factor Increases the Activity of the Promoter of the Insulin-like Growth Factor-1 (IGF-1) Receptor Gene

1994 • 103 citations

Parallel Phosphatidylinositol-3 Kinase and p42/44 Mitogen-Activated Protein Kinase Signaling Pathways Subserve the Mitogenic and Antiapoptotic Actions of Insulin-Like Growth Factor I in Osteoblastic Cells

2003 • 101 citations

Structure and Function of a Human Insulin-like Growth Factor-I Gene Promoter

1991 • 100 citations

Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats

1994 • 99 citations

Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone.

1988 • 98 citations

Characterization of Insulin-Like Growth Factor I Receptors on Cultured Rat Bone Cells: Regulation of Receptor Concentration by Glucocorticoids*

1984 • 97 citations

Transgenic Mice Overexpressing Insulin-Like Growth Factor Binding Protein-5 Display Transiently Decreased Osteoblastic Function and Osteopenia

2002 • 96 citations

Stat1 Controls Postnatal Bone Formation by Regulating Fibroblast Growth Factor Signaling in Osteoblasts

2004 • 96 citations

Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects.

1993 • 95 citations

Paracrine Overexpression of IGFBP-4 in Osteoblasts of Transgenic Mice Decreases Bone Turnover and Causes Global Growth Retardation

2003 • 95 citations

Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen.

1998 • 95 citations

Skeletal Growth Factors

2001 • 94 citations

Functional Characterization of the Human Basic Fibroblast Growth Factor Gene Promoter

1991 • 93 citations

Systemic Administration of Insulin-Like Growth Factor (IGF)-Binding Protein-4 (IGFBP-4) Increases Bone Formation Parameters in Mice by Increasing IGF Bioavailability via an IGFBP-4 Protease-Dependent Mechanism*

2001 • 93 citations

Molecular Cloning and Structure of the Human Transforming Growth Factor-β2 Gene Promoter

1991 • 92 citations

Insulin Receptor Substrate-1 Is Required for Bone Anabolic Function of Parathyroid Hormone in Mice

2005 • 92 citations

Targeted Overexpression of Insulin-Like Growth Factor I to Osteoblasts of Transgenic Mice: Increased Trabecular Bone Volume without Increased Osteoblast Proliferation

2000 • 91 citations

Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.

1993 • 90 citations

Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells.

1994 • 84 citations

Platelet-Derived Growth Factor Structure, function and implications in normal and malignant cell growth

1993 • 83 citations

Response of Bipotential Human Marrow Stromal Cells to Insulin-Like Growth Factors: Effect on Binding Protein Production, Proliferation, and Commitment to Osteoblasts and Adipocytes1

1999 • 83 citations

Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging

1994 • 82 citations

Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells.

1995 • 81 citations

Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation.

1993 • 80 citations

Changes in insulin-like growth factor-binding protein expression and secretion during the proliferation, differentiation, and mineralization of primary cultures of rat osteoblasts.

1994 • 79 citations

Perturbations in Bone Formation and Resorption in Insulin-Like Growth Factor Binding Protein-3 Transgenic Mice

2003 • 77 citations

Effects of Recombinant Human IGF-I and Oral Contraceptive Administration on Bone Density in Anorexia Nervosa

2002 • 77 citations

Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells.

1995 • 76 citations

Adenovirus‐mediated VEGF‐A gene transfer induces bone formationin vivo

2003 • 76 citations

A Potentially Deleterious Role of IGFBP-2 on Bone Density in Aging Men and Women

2004 • 75 citations

Effects of endothelial cell growth factor on bone remodelling in vitro.

1987 • 75 citations

Systemic administration of recombinant transforming growth factor beta 2 (rTGF-β2) stimulates parameters of cancellous bone formation in juvenile and adult rats

1994 • 73 citations

1,25-Dihydroxyvitamin D₃[1,25-(OH)₂D₃] Increases Insulin-Like Growth Factor I (IGF-I) Receptors in Clonal Osteoblastic Cells. Study on Interaction of IGF-I and 1,25-(OH)₂D₃*

1990 • 72 citations

Expression of the BMP 2 Gene during Bone Cell Differentiation

1994 • 72 citations

Short-term effects of recombinant human insulin-like growth factor I on bone turnover in normal women

1993 • 71 citations

Growth Inhibitory Effects of Transforming Growth Factor-β1 in vivo

1991 • 71 citations

Over‐expression of fibroblast growth factor‐2 causes defective bone mineralization and osteopenia in transgenic mice

2005 • 67 citations

Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice

2002 • 66 citations

Insulin-like growth factor-I supports formation and activation of osteoclasts

1992 • 65 citations

Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.

1992 • 64 citations

Insulin-like growth factor binding protein proteolysis in bone cell models

1995 • 63 citations

Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation

1991 • 61 citations

Protective action of hepatocyte growth factor for acute liver injury caused byD-galactosamine in transgenic mice

1997 • 61 citations

Regulation of Collagenase-3 by Bone Morphogenetic Protein-2 in Bone Cell Cultures*

1997 • 61 citations

Effect of platelet‐derived growth factor on DNA synthesis and gene expression in bone marrow stromal cells derived from adult and old rats

1995 • 60 citations

Recombinant Human Transforming Growth Factor—Beta 1 (rhTGF-β1) Enhances Healing and Strength of Granulation Skin Wounds

1990 • 58 citations

Impaired Osteoclast Formation in Bone Marrow Cultures of Fgf2 Null Mice in Response to Parathyroid Hormone

2003 • 57 citations

Prostaglandin F2 alpha stimulates proliferation of clonal osteoblastic MC3T3-E1 cells by up-regulation of insulin-like growth factor I receptors.

1991 • 57 citations

Skeletal Growth Factors Regulate the Synthesis of Insulin-like Growth Factor Binding Protein-5 in Bone Cell Cultures

1995 • 56 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

1993 • 55 citations

Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts

2003 • 55 citations

Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site*

2000 • 54 citations

Bone morphogenetic protein 2 increases insulin-like growth factor I and II transcripts and polypeptide levels in bone cell cultures

1994 • 53 citations

Fibroblast Growth Factor-2 Induces Hepatocyte Growth Factor/Scatter Factor Expression in Osteoblasts*

1999 • 51 citations

AU-Rich Elements in the Collagenase 3 mRNA Mediate Stabilization of the Transcript by Cortisol in Osteoblasts

2004 • 51 citations

Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts

2000 • 50 citations

Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line specific

1992 • 50 citations

Transcriptional and posttranscriptional regulation of interstitial collagenase by platelet-derived growth factor BB in bone cell cultures.

1996 • 49 citations

Regulation of insulin-like growth factor-II synthesis in bone cell cultures by skeletal growth factors.

1994 • 47 citations

Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures.

1994 • 47 citations

Determination and expression of platelet-derived growth factor-AA in bone cell cultures.

1992 • 46 citations

Twisted Perspective

2001 • 45 citations

Extracellular Matrix-Associated Bone Morphogenetic Proteins Are Essential for Differentiation of Murine Osteoblastic Cells in Vitro

1999 • 45 citations

Regulation of Growth Plate Chondrogenesis by Bone Morphogenetic Protein-2

2001 • 45 citations

Hepatocyte Growth Factor Contributes to Fracture Repair by Upregulating the Expression of BMP Receptors

2005 • 44 citations

High-affinity binding of PDGF-AA and PDGF-BB to normal human osteoblastic cells and modulation by interleukin-1

1991 • 44 citations

Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts

2000 • 44 citations

Bone Anabolic Effects of Sonic/Indian Hedgehog Are Mediated By BMP-2/4-Dependent Pathways in the Neonatal Rat Metatarsal Model

2001 • 43 citations

Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts

1994 • 42 citations

1,25-Dihydroxyvitamin D3 stimulates the secretion of insulin-like growth factor binding protein 3 (IGFBP-3) by cultured human osteosarcoma cells.

1992 • 41 citations

Hepatocyte growth factor: another ubiquitous cytokine

1993 • 39 citations

p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts

2003 • 38 citations

Growth factor modulation of insulin-like growth factor-binding proteins in rat osteoblast-like cells.

1993 • 38 citations

Interleukin-6 and Its Soluble Receptor Regulate the Expression of Insulin-Like Growth Factor Binding Protein-5 in Osteoblast Cultures*

1997 • 37 citations

Glucocorticoid-induced activation of latent transforming growth factor- beta by normal human osteoblast-like cells

1993 • 37 citations

Differential Binding and Regulation of Platelet-derived Growth Factor A and B Chain Isoforms by α2-Macroglobulin

1995 • 37 citations

Glucocorticoid Suppression of IGF I Transcription in Osteoblasts

2001 • 36 citations

Recombinant Human Insulin-Like Growth Factor-Binding Protein-5 Stimulates Bone Formation Parameters in Vitro and in Vivo

1999 • 36 citations

Acceleration of Fracture Healing in Nonhuman Primates by Fibroblast Growth Factor-2

2001 • 35 citations

Insulin-like growth factor-I increases trabecular bone formation and osteoblastic cell proliferation in unloaded rats

1994 • 35 citations

Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures

1995 • 35 citations

Noggin arrests stromal cell differentiation in vitro☆☆This work was supported by Grant AR21707 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Grant DK45227 from the National Institute of Diabetes, Digestive and Kidney Diseases.

2003 • 34 citations

Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases

1994 • 34 citations

Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells

1994 • 32 citations

Response of Bipotential Human Marrow Stromal Cells to Insulin-Like Growth Factors: Effect on Binding Protein Production, Proliferation, and Commitment to Osteoblasts and Adipocytes

1999 • 28 citations

Characterization of a Novel Platelet‐Derived Growth Factor‐Associated Protein

1996 • 28 citations

Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures

1993 • 27 citations

Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro

2004 • 27 citations

Induction of Vascular Endothelial Growth Factor by IGF-I in Osteoblast-Like Cells Is Mediated by the PI3K Signaling Pathway through the Hypoxia-Inducible Factor-2

2002 • 25 citations

Pro-inflammatory cytokines downregulate platelet derived growth factor-α receptor gene expression in human osteoblastic cells

1996 • 25 citations

Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells

1995 • 24 citations

Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts

2000 • 24 citations

Changes in insulin-like growth factor-binding protein expression and secretion during the proliferation, differentiation, and mineralization of primary cultures of rat osteoblasts

1994 • 24 citations

Systemic Administration of Insulin-Like Growth Factor (IGF)-Binding Protein-4 (IGFBP-4) Increases Bone Formation Parameters in Mice by Increasing IGF Bioavailability via an IGFBP-4 Protease-Dependent Mechanism

2001 • 23 citations

Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site

2000 • 21 citations

Insulin-Like Growth Factor II Promoter Expression in Cultured Rodent Osteoblasts and Adult Rat Bone*

1998 • 21 citations

Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation

1993 • 20 citations

SAPK/JNK Plays a Role in Transforming Growth Factor-β-induced VEGF Synthesis in Osteoblasts

2005 • 17 citations

Bone morphogenetic protein‐2 suppresses collagenase‐3 promoter activity in osteoblasts through a runt domain factor 2 binding site

2004 • 17 citations

Skeletal growth factors and aging

1994 • 16 citations

Determination and expression of platelet-derived growth factor-AA in bone cell cultures

1992 • 16 citations

Regulation of Collagenase-3 by Bone Morphogenetic Protein-2 in Bone Cell Cultures

1997 • 15 citations

Regulation of insulin-like growth factor-II synthesis in bone cell cultures by skeletal growth factors

1994 • 15 citations

Transcriptional and posttranscriptional regulation of interstitial collagenase by platelet-derived growth factor BB in bone cell cultures

1996 • 14 citations

Bone Anabolic Effects of Sonic/Indian Hedgehog Are Mediated By BMP-2/4-Dependent Pathways in the Neonatal Rat Metatarsal Model

2001 • 12 citations

Interleukin-6 and Its Soluble Receptor Regulate the Expression of Insulin-Like Growth Factor Binding Protein-5 in Osteoblast Cultures

1997 • 11 citations

Growth factor modulation of insulin-like growth factor-binding proteins in rat osteoblast-like cells

1993 • 11 citations

1,25-Dihydroxyvitamin D3 stimulates the secretion of insulin-like growth factor binding protein 3 (IGFBP-3) by cultured human osteosarcoma cells

1992 • 10 citations

Fibroblast Growth Factor-2 Induces Hepatocyte Growth Factor/Scatter Factor Expression in Osteoblasts

1999 • 10 citations

Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures

1994 • 10 citations

Insulin-Like Growth Factor II Promoter Expression in Cultured Rodent Osteoblasts and Adult Rat Bone

1998 • 8 citations